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58 results
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Topoisomerase-mediated chromosomal break repair: an emerging player in many games.
Ashour ME, Atteya R, El-Khamisy SF. Ashour ME, et al. Nat Rev Cancer. 2015 Mar;15(3):137-51. doi: 10.1038/nrc3892. Epub 2015 Feb 19. Nat Rev Cancer. 2015. PMID: 25693836 Review.
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.
Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang SC, Ray S, Ashour ME, Sudbery I, Dickman MJ, El-Khamisy SF. Liao C, et al. Cell Rep. 2018 Jun 12;23(11):3352-3365. doi: 10.1016/j.celrep.2018.05.033. Cell Rep. 2018. PMID: 29898404 Free PMC article.
Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1.
Elsayed W, El-Shafie L, Hassan MK, Farag MA, El-Khamisy SF. Elsayed W, et al. Sci Rep. 2016 May 25;6:26626. doi: 10.1038/srep26626. Sci Rep. 2016. PMID: 27220325 Free PMC article.
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.
Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, Myszczynska MA, Alam SM, Garneret P, Chandran JS, Karyka E, Stopford MJ, Smith EF, Kirby J, Meyer K, Kaspar BK, Isaacs AM, El-Khamisy SF, De Vos KJ, Ning K, Azzouz M, Whitworth AJ, Shaw PJ. Hautbergue GM, et al. Nat Commun. 2017 Jul 5;8:16063. doi: 10.1038/ncomms16063. Nat Commun. 2017. PMID: 28677678 Free PMC article.
DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms.
Abugable AA, Morris JLM, Palminha NM, Zaksauskaite R, Ray S, El-Khamisy SF. Abugable AA, et al. Among authors: el khamisy sf. DNA Repair (Amst). 2019 Sep;81:102669. doi: 10.1016/j.dnarep.2019.102669. Epub 2019 Jul 8. DNA Repair (Amst). 2019. PMID: 31331820 Free article. Review.
Gold nanoparticles - an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis.
Shawky SM, Awad AM, Abugable AA, El-Khamisy SF. Shawky SM, et al. Among authors: el khamisy sf. Int J Nanomedicine. 2018 Nov 29;13:8137-8151. doi: 10.2147/IJN.S181732. eCollection 2018. Int J Nanomedicine. 2018. PMID: 30555231 Free PMC article.
Rad5, HLTF, and SHPRH: A Fresh View of an Old Story.
Elserafy M, Abugable AA, Atteya R, El-Khamisy SF. Elserafy M, et al. Trends Genet. 2018 Aug;34(8):574-577. doi: 10.1016/j.tig.2018.04.006. Epub 2018 May 26. Trends Genet. 2018. PMID: 29807746 Free PMC article. Review.
Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs.
Hegazy MT, Allam WR, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF, Ragab G; Mediterranean Consortium for the study of Cryoglobulinemic Vasculitis. Hegazy MT, et al. Among authors: el khamisy sf. EBioMedicine. 2018 Sep;35:106-113. doi: 10.1016/j.ebiom.2018.08.007. Epub 2018 Aug 20. EBioMedicine. 2018. PMID: 30139628 Free PMC article. Clinical Trial.
Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia.
Walker C, El-Khamisy SF. Walker C, et al. Brain. 2018 May 1;141(5):1247-1262. doi: 10.1093/brain/awy076. Brain. 2018. PMID: 29584802 Free PMC article. Review.
Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.
Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF. Meisenberg C, et al. Nucleic Acids Res. 2017 Feb 17;45(3):1159-1176. doi: 10.1093/nar/gkw1026. Nucleic Acids Res. 2017. PMID: 28180300 Free PMC article.
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