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The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.
Khalil BD, Hanna S, Saykali BA, El-Sitt S, Nasrallah A, Marston D, El-Sabban M, Hahn KM, Symons M, El-Sibai M. Khalil BD, et al. Exp Cell Res. 2014 Feb 15;321(2):109-22. doi: 10.1016/j.yexcr.2013.11.023. Epub 2013 Dec 10. Exp Cell Res. 2014. PMID: 24333506 Free PMC article.
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells.
Sarmiento C, Wang W, Dovas A, Yamaguchi H, Sidani M, El-Sibai M, Desmarais V, Holman HA, Kitchen S, Backer JM, Alberts A, Condeelis J. Sarmiento C, et al. J Cell Biol. 2008 Mar 24;180(6):1245-60. doi: 10.1083/jcb.200708123. J Cell Biol. 2008. PMID: 18362183 Free PMC article.
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.
El-Sibai M, Pertz O, Pang H, Yip SC, Lorenz M, Symons M, Condeelis JS, Hahn KM, Backer JM. El-Sibai M, et al. Exp Cell Res. 2008 Apr 15;314(7):1540-52. doi: 10.1016/j.yexcr.2008.01.016. Epub 2008 Feb 2. Exp Cell Res. 2008. PMID: 18316075 Free PMC article.
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells.
Sidani M, Wessels D, Mouneimne G, Ghosh M, Goswami S, Sarmiento C, Wang W, Kuhl S, El-Sibai M, Backer JM, Eddy R, Soll D, Condeelis J. Sidani M, et al. J Cell Biol. 2007 Nov 19;179(4):777-91. doi: 10.1083/jcb.200707009. J Cell Biol. 2007. PMID: 18025308 Free PMC article.
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.
El-Sibai M, Nalbant P, Pang H, Flinn RJ, Sarmiento C, Macaluso F, Cammer M, Condeelis JS, Hahn KM, Backer JM. El-Sibai M, et al. J Cell Sci. 2007 Oct 1;120(Pt 19):3465-74. doi: 10.1242/jcs.005942. Epub 2007 Sep 12. J Cell Sci. 2007. PMID: 17855387 Free PMC article.
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.
Yip SC, El-Sibai M, Coniglio SJ, Mouneimne G, Eddy RJ, Drees BE, Neilsen PO, Goswami S, Symons M, Condeelis JS, Backer JM. Yip SC, et al. J Cell Sci. 2007 Sep 1;120(Pt 17):3138-46. doi: 10.1242/jcs.005298. Epub 2007 Aug 14. J Cell Sci. 2007. PMID: 17698922 Free PMC article.
Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.
Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Wu H, et al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20258-63. doi: 10.1073/pnas.0902369106. Epub 2009 Nov 13. Proc Natl Acad Sci U S A. 2009. PMID: 19915146 Free PMC article.
StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion.
Hanna S, Khalil B, Nasrallah A, Saykali BA, Sobh R, Nasser S, El-Sibai M. Hanna S, et al. Int J Oncol. 2014 May;44(5):1499-511. doi: 10.3892/ijo.2014.2330. Epub 2014 Mar 7. Int J Oncol. 2014. PMID: 24627003 Free PMC article.
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