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Differential suppression of proliferation in MCF-7 and MDA-MB-231 breast cancer cells exposed to alpha-, gamma- and delta-tocotrienols is accompanied by altered expression of oxidative stress modulatory enzymes.

Hsieh TC, Elangovan S, Wu JM. Hsieh TC, et al. Among authors: elangovan s. Anticancer Res. 2010 Oct;30(10):4169-76. Anticancer Res. 2010. PMID: 21036737

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The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.

Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Lan L, Singh N, Martin PM, Hawthorn L, Prasad PD, Ganapathy V, Thangaraju M. Elangovan S, et al. Cancer Res. 2014 Feb 15;74(4):1166-78. doi: 10.1158/0008-5472.CAN-13-1451. Epub 2013 Dec 26. Cancer Res. 2014. PMID: 24371223 Free PMC article.

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Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate.

Thangaraju M, Karunakaran SK, Itagaki S, Gopal E, Elangovan S, Prasad PD, Ganapathy V. Thangaraju M, et al. Among authors: elangovan s. Cancer. 2009 Oct 15;115(20):4655-66. doi: 10.1002/cncr.24532. Cancer. 2009. PMID: 19637353 Free PMC article.

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gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells.

Hsieh TC, Elangovan S, Wu JM. Hsieh TC, et al. Among authors: elangovan s. Anticancer Res. 2010 Jul;30(7):2869-74. Anticancer Res. 2010. PMID: 20683025

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α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling.

Tripathy J, Tripathy A, Thangaraju M, Suar M, Elangovan S. Tripathy J, et al. Among authors: elangovan s. Life Sci. 2018 Aug 15;207:15-22. doi: 10.1016/j.lfs.2018.05.039. Epub 2018 May 23. Life Sci. 2018. PMID: 29802942

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Molecular mechanism of SLC5A8 inactivation in breast cancer.

Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M. Elangovan S, et al. Mol Cell Biol. 2013 Oct;33(19):3920-35. doi: 10.1128/MCB.01702-12. Epub 2013 Aug 5. Mol Cell Biol. 2013. PMID: 23918800 Free PMC article.

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The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function.

Coothankandaswamy V, Elangovan S, Singh N, Prasad PD, Thangaraju M, Ganapathy V. Coothankandaswamy V, et al. Among authors: elangovan s. Biochem J. 2013 Feb 15;450(1):169-78. doi: 10.1042/BJ20121248. Biochem J. 2013. PMID: 23167260 Free PMC article.

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GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

Gambhir D, Ananth S, Veeranan-Karmegam R, Elangovan S, Hester S, Jennings E, Offermanns S, Nussbaum JJ, Smith SB, Thangaraju M, Ganapathy V, Martin PM. Gambhir D, et al. Among authors: elangovan s. Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2208-17. doi: 10.1167/iovs.11-8447. Invest Ophthalmol Vis Sci. 2012. PMID: 22427566 Free PMC article.

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SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer.

Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M. Elangovan S, et al. Cancer Res. 2011 Nov 1;71(21):6654-64. doi: 10.1158/0008-5472.CAN-11-1446. Epub 2011 Sep 15. Cancer Res. 2011. PMID: 21920899 Free PMC article.

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SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer.

Karunakaran S, Ramachandran S, Coothankandaswamy V, Elangovan S, Babu E, Periyasamy-Thandavan S, Gurav A, Gnanaprakasam JP, Singh N, Schoenlein PV, Prasad PD, Thangaraju M, Ganapathy V. Karunakaran S, et al. Among authors: elangovan s. J Biol Chem. 2011 Sep 9;286(36):31830-8. doi: 10.1074/jbc.M111.229518. Epub 2011 Jul 19. J Biol Chem. 2011. PMID: 21771784 Free PMC article.

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