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1988 1
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Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases.
Pattison DI, Davies MJ. Pattison DI, et al. Curr Med Chem. 2006;13(27):3271-90. doi: 10.2174/092986706778773095. Curr Med Chem. 2006. PMID: 17168851 Review.
The heme enzyme myeloperoxidase (MPO) is released at sites of inflammation by activated leukocytes. A key function of MPO is the production of hypohalous acids (HOX, X = Cl, Br) which are strong oxidants with potent antibacterial properties. However, HOX can also damage ho …
The heme enzyme myeloperoxidase (MPO) is released at sites of inflammation by activated leukocytes. A key function of MPO is the prod …
Cysteine and glutathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine.
Dröge W. Dröge W. Pharmacology. 1993;46(2):61-5. doi: 10.1159/000139029. Pharmacology. 1993. PMID: 8441757 Review.
HIV-infected persons at all stages of the disease were found to have decreased plasma cystine and cysteine concentrations and decreased intracellular glutathione levels. ...Increased glutamate levels aggravate the cysteine deficiency by inhibiting the membrane transport of …
HIV-infected persons at all stages of the disease were found to have decreased plasma cystine and cysteine concentrations and decreas …
HIV-induced cysteine deficiency and T-cell dysfunction--a rationale for treatment with N-acetylcysteine.
Dröge W, Eck HP, Mihm S. Dröge W, et al. Immunol Today. 1992 Jun;13(6):211-4. doi: 10.1016/0167-5699(92)90156-2. Immunol Today. 1992. PMID: 1378279 Review.
Markedly decreased plasma cystine and cysteine concentrations have been found in HIV-infected patients at all stages of the disease and in SIV-infected rhesus macaques. The elevated glutamate levels found in the same patients aggravate the cysteine deficiency by inh …
Markedly decreased plasma cystine and cysteine concentrations have been found in HIV-infected patients at all stages of the disease a …
NIH conference. Cystinosis: progress in a prototypic disease.
Gahl WA, Thoene JG, Schneider JA, O'Regan S, Kaiser-Kupfer MI, Kuwabara T. Gahl WA, et al. Ann Intern Med. 1988 Oct 1;109(7):557-69. doi: 10.7326/0003-4819-109-7-557. Ann Intern Med. 1988. PMID: 3048161 Review.
PATIENTS: One hundred forty-eight children, aged 0 to 12, with nephropathic cystinosis before renal transplant, who had renal tubular Fanconi syndrome, failure to grow, corneal cystine crystals, and elevated leukocyte cystine; 34 patients, aged 9 to 29 …
PATIENTS: One hundred forty-eight children, aged 0 to 12, with nephropathic cystinosis before renal transplant, who had renal tubular Fancon …
Requirement for prooxidant and antioxidant states in T cell mediated immune responses.--Relevance for the pathogenetic mechanisms of AIDS?
Dröge W, Eck HP, Gmünder H, Mihm S. Dröge W, et al. Klin Wochenschr. 1991 Dec 15;69(21-23):1118-22. doi: 10.1007/BF01645171. Klin Wochenschr. 1991. PMID: 1798289 Review.
The discovery of decreased plasma cysteine and cystine levels and elevated plasma glutamate levels in HIV-infected patients has led to intense investigations into the role of cysteine in T cell-mediated immune responses. ...The relatively high cystine transpo …
The discovery of decreased plasma cysteine and cystine levels and elevated plasma glutamate levels in HIV-infected patients ha …