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The small RNA miR-375 - a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function.
Eliasson L. Eliasson L. Mol Cell Endocrinol. 2017 Nov 15;456:95-101. doi: 10.1016/j.mce.2017.02.043. Epub 2017 Feb 27. Mol Cell Endocrinol. 2017. PMID: 28254488 Review.
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
Barg S, Eliasson L, Renström E, Rorsman P. Barg S, et al. Among authors: eliasson l. Diabetes. 2002 Feb;51 Suppl 1:S74-82. doi: 10.2337/diabetes.51.2007.s74. Diabetes. 2002. PMID: 11815462 Review.
Requirement for N-ethylmaleimide-sensitive factor for exocytosis of insulin-containing secretory granules in pancreatic beta-cells.
Vikman J, Ma X, Tagaya M, Eliasson L. Vikman J, et al. Among authors: eliasson l. Biochem Soc Trans. 2003 Aug;31(Pt 4):842-7. doi: 10.1042/bst0310842. Biochem Soc Trans. 2003. PMID: 12887318
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.
Göpel S, Zhang Q, Eliasson L, Ma XS, Galvanovskis J, Kanno T, Salehi A, Rorsman P. Göpel S, et al. Among authors: eliasson l. J Physiol. 2004 May 1;556(Pt 3):711-26. doi: 10.1113/jphysiol.2003.059675. Epub 2004 Feb 13. J Physiol. 2004. PMID: 14966302 Free PMC article.
Both exocytosis (measured by capacitance measurements) and insulin release (detected by radioimmunoassay) were strongly inhibited by the L-type Ca(2+) channel blocker nifedipine (25 microm) but only marginally (<20%) affected by the R-type Ca(2+) channel blocker SNX482 …
Both exocytosis (measured by capacitance measurements) and insulin release (detected by radioimmunoassay) were strongly inhibited by the …
Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
Ma X, Zhang Y, Gromada J, Sewing S, Berggren PO, Buschard K, Salehi A, Vikman J, Rorsman P, Eliasson L. Ma X, et al. Among authors: eliasson l. Mol Endocrinol. 2005 Jan;19(1):198-212. doi: 10.1210/me.2004-0059. Epub 2004 Sep 30. Mol Endocrinol. 2005. PMID: 15459251
A pancreatic islet-specific microRNA regulates insulin secretion.
Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M. Poy MN, et al. Among authors: eliasson l. Nature. 2004 Nov 11;432(7014):226-30. doi: 10.1038/nature03076. Nature. 2004. PMID: 15538371
Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells.
Vikman J, Ma X, Hockerman GH, Rorsman P, Eliasson L. Vikman J, et al. Among authors: eliasson l. J Mol Endocrinol. 2006 Jun;36(3):503-15. doi: 10.1677/jme.1.01978. J Mol Endocrinol. 2006. PMID: 16720719
Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: evidence for the existence of insulinotropic agents in the stomach.
Salehi A, Eliasson L, Ma X, Rorsman P, Håkanson R, Lundquist I. Salehi A, et al. Among authors: eliasson l. Regul Pept. 2007 Mar 1;139(1-3):31-8. doi: 10.1016/j.regpep.2006.10.001. Epub 2006 Nov 15. Regul Pept. 2007. PMID: 17109976
Freshly isolated islets from GX mice had higher cAMP content than islets from control mice, a difference that persisted after incubation for 1 h at a glucose concentration of 4 mmol/l. ...In contrast, the insulin response to high glucose (16.7 mmol/l) was much weake …
Freshly isolated islets from GX mice had higher cAMP content than islets from control mice, a difference that persisted after incubation for …
Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.
Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, Holst LS. Walz HA, et al. Among authors: eliasson l. Cell Signal. 2007 Jul;19(7):1505-13. doi: 10.1016/j.cellsig.2007.01.030. Epub 2007 Feb 12. Cell Signal. 2007. PMID: 17368848
Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.
Olofsson CS, Collins S, Bengtsson M, Eliasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P. Olofsson CS, et al. Among authors: eliasson l. Diabetes. 2007 Jul;56(7):1888-97. doi: 10.2337/db06-1150. Epub 2007 Apr 24. Diabetes. 2007. PMID: 17456851
However, they released 20% less insulin when challenged with 20 mmol/l glucose. Glucose-induced (20 mmol/l) insulin secretion was reduced by 60-90% in islets cocultured at 4.5 or 15 mmol/l glucose and either oleate or palmitate (0.5 mmol/l). ...Basal ( …
However, they released 20% less insulin when challenged with 20 mmol/l glucose. Glucose-induced (20 mmol/l) insulin secretion …
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