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Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis.
Laschke MW, Elitzsch A, Scheuer C, Vollmar B, Menger MD. Laschke MW, et al. Among authors: elitzsch a. Fertil Steril. 2007 Jan;87(1):163-71. doi: 10.1016/j.fertnstert.2006.05.068. Epub 2006 Nov 1. Fertil Steril. 2007. PMID: 17081538
Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions.
Laschke MW, Elitzsch A, Vollmar B, Vajkoczy P, Menger MD. Laschke MW, et al. Among authors: elitzsch a. Hum Reprod. 2006 Jan;21(1):262-8. doi: 10.1093/humrep/dei308. Epub 2005 Sep 19. Hum Reprod. 2006. PMID: 16172144
Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation.
Laschke MW, Elitzsch A, Scheuer C, Holstein JH, Vollmar B, Menger MD. Laschke MW, et al. Among authors: elitzsch a. Br J Pharmacol. 2006 Sep;149(2):137-44. doi: 10.1038/sj.bjp.0706857. Epub 2006 Aug 7. Br J Pharmacol. 2006. PMID: 16894343 Free PMC article.
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