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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. Harper JW, et al. Among authors: elledge sj. Cell. 1993 Nov 19;75(4):805-16. doi: 10.1016/0092-8674(93)90499-g. Cell. 1993. PMID: 8242751
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM. Koff A, et al. Among authors: elledge s. Science. 1992 Sep 18;257(5077):1689-94. doi: 10.1126/science.1388288. Science. 1992. PMID: 1388288
A genetic screen for candidate tumor suppressors identifies REST.
Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. Westbrook TF, et al. Among authors: elledge sj. Cell. 2005 Jun 17;121(6):837-48. doi: 10.1016/j.cell.2005.03.033. Cell. 2005. PMID: 15960972
Multiple tumor suppressor pathways negatively regulate telomerase.
Lin SY, Elledge SJ. Lin SY, et al. Among authors: elledge sj. Cell. 2003 Jun 27;113(7):881-9. doi: 10.1016/s0092-8674(03)00430-6. Cell. 2003. PMID: 12837246
Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.
Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Sack LM, et al. Among authors: elledge sj. Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22. Cell. 2018. PMID: 29576454 Free PMC article.
Cyclin F disruption compromises placental development and affects normal cell cycle execution.
Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA, Elledge SJ. Tetzlaff MT, et al. Among authors: elledge sj. Mol Cell Biol. 2004 Mar;24(6):2487-98. doi: 10.1128/mcb.24.6.2487-2498.2004. Mol Cell Biol. 2004. PMID: 14993286 Free PMC article.
53BP1 oligomerization is independent of its methylation by PRMT1.
Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB. Adams MM, et al. Among authors: elledge sj. Cell Cycle. 2005 Dec;4(12):1854-61. doi: 10.4161/cc.4.12.2282. Epub 2005 Dec 28. Cell Cycle. 2005. PMID: 16294047
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.
Lin SY, Li K, Stewart GS, Elledge SJ. Lin SY, et al. Among authors: elledge sj. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6484-9. doi: 10.1073/pnas.0401847101. Epub 2004 Apr 19. Proc Natl Acad Sci U S A. 2004. PMID: 15096610 Free PMC article.
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW. Xu L, et al. Among authors: elledge sj. Nature. 2003 Sep 18;425(6955):316-21. doi: 10.1038/nature01985. Epub 2003 Sep 3. Nature. 2003. PMID: 13679922
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.
Osborn AJ, Elledge SJ. Osborn AJ, et al. Among authors: elledge sj. Genes Dev. 2003 Jul 15;17(14):1755-67. doi: 10.1101/gad.1098303. Genes Dev. 2003. PMID: 12865299 Free PMC article.
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