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Clostridium difficile-associated diarrhoea.
Elliott B, Chang BJ, Golledge CL, Riley TV. Elliott B, et al. Intern Med J. 2007 Aug;37(8):561-8. doi: 10.1111/j.1445-5994.2007.01403.x. Intern Med J. 2007. PMID: 17640189 Review.
Toxigenic strains usually produce toxin A and toxin B, which are the primary virulence factors of C. difficile. Some recently described strains produce an additional toxin, an adenosine-diphosphate ribosyltransferase known as binary toxin, the role of which in pathogenicit …
Toxigenic strains usually produce toxin A and toxin B, which are the primary virulence factors of C. difficile. Some recently describ …
Bacteremia with a large clostridial toxin-negative, binary toxin-positive strain of Clostridium difficile.
Elliott B, Reed R, Chang BJ, Riley TV. Elliott B, et al. Anaerobe. 2009 Dec;15(6):249-51. doi: 10.1016/j.anaerobe.2009.08.006. Epub 2009 Aug 31. Anaerobe. 2009. PMID: 19723585
The isolate contained neither toxin A nor B genes, however, binary toxin genes were present (tcdA(-), tcdB(-), cdtA(+), cdtB(+)) and a 7.2-kb element unrelated to the PaLoc was found inserted within the PaLoc integration site. ...
The isolate contained neither toxin A nor B genes, however, binary toxin genes were present (tcdA(-), tcdB(-), cdtA(+), cdtB(+)) and …
New types of toxin A-negative, toxin B-positive strains among clinical isolates of Clostridium difficile in Australia.
Elliott B, Squire MM, Thean S, Chang BJ, Brazier JS, Rupnik M, Riley TV. Elliott B, et al. J Med Microbiol. 2011 Aug;60(Pt 8):1108-1111. doi: 10.1099/jmm.0.031062-0. Epub 2011 Mar 10. J Med Microbiol. 2011. PMID: 21393460
Two new A(-)B(+) toxinotypes were also defined (XXX, XXXI). Toxinotype XXX had a toxin B gene similar to that of toxinotype IV (A(+)B(+)) but with a novel cytopathic region. ...The types of A(-)B(+) strains identified in this study differed markedly fr …
Two new A(-)B(+) toxinotypes were also defined (XXX, XXXI). Toxinotype XXX had a toxin B gene similar to that of toxinotype IV …
Clostridium difficile in horses in Australia--a preliminary study.
Thean S, Elliott B, Riley TV. Thean S, et al. J Med Microbiol. 2011 Aug;60(Pt 8):1188-1192. doi: 10.1099/jmm.0.030908-0. Epub 2011 Mar 24. J Med Microbiol. 2011. PMID: 21436371
These isolates were toxin profiled by PCR for toxin A, toxin B and binary toxin, and ribotyped. Ten of the equine isolates were A(+)B(+)CDT(-). Other toxin profiles detected were A(-)B(-)CDT(+) (one isolate), A(+)B(+)CDT(+) (two isolates) and A(-)B
These isolates were toxin profiled by PCR for toxin A, toxin B and binary toxin, and ribotyped. Ten of the equine isolates were A(+) …
Novel molecular type of Clostridium difficile in neonatal pigs, Western Australia.
Squire MM, Carter GP, Mackin KE, Chakravorty A, Norén T, Elliott B, Lyras D, Riley TV. Squire MM, et al. Emerg Infect Dis. 2013 May;19(5):790-2. doi: 10.3201/eid1905.121062. Emerg Infect Dis. 2013. PMID: 23697508 Free PMC article.
Evolutionary history of the Clostridium difficile pathogenicity locus.
Dingle KE, Elliott B, Robinson E, Griffiths D, Eyre DW, Stoesser N, Vaughan A, Golubchik T, Fawley WN, Wilcox MH, Peto TE, Walker AS, Riley TV, Crook DW, Didelot X. Dingle KE, et al. Genome Biol Evol. 2014 Jan;6(1):36-52. doi: 10.1093/gbe/evt204. Genome Biol Evol. 2014. PMID: 24336451 Free PMC article.
Emergence of a ribotype 244 strain of Clostridium difficile associated with severe disease and related to the epidemic ribotype 027 strain.
Lim SK, Stuart RL, Mackin KE, Carter GP, Kotsanas D, Francis MJ, Easton M, Dimovski K, Elliott B, Riley TV, Hogg G, Paul E, Korman TM, Seemann T, Stinear TP, Lyras D, Jenkin GA. Lim SK, et al. Clin Infect Dis. 2014 Jun;58(12):1723-30. doi: 10.1093/cid/ciu203. Epub 2014 Apr 4. Clin Infect Dis. 2014. PMID: 24704722
The pathogenicity locus of the RT244 strain encodes a variant toxin B, and this was confirmed by demonstration of Clostridium sordellii-like cytopathic effect on Vero cells. Toxin B production in culture supernatants was lower than that seen with a RT027 strain. CON …
The pathogenicity locus of the RT244 strain encodes a variant toxin B, and this was confirmed by demonstration of Clostridium sordell …
The complexity and diversity of the Pathogenicity Locus in Clostridium difficile clade 5.
Elliott B, Dingle KE, Didelot X, Crook DW, Riley TV. Elliott B, et al. Genome Biol Evol. 2014 Nov 8;6(12):3159-70. doi: 10.1093/gbe/evu248. Genome Biol Evol. 2014. PMID: 25381663 Free PMC article.
Comparison of the core genome and PaLoc phylogenies obtained for clade 5 and representatives of the other clades identified two distinct PaLoc acquisition events, one involving a toxin A(+)B(+) PaLoc variant and the other an A(-)B(+) variant. ...A variant of the put …
Comparison of the core genome and PaLoc phylogenies obtained for clade 5 and representatives of the other clades identified two distinct PaL …
Evaluation of the Cepheid Xpert C. difficile/Epi and meridian bioscience illumigene C. difficile assays for detecting Clostridium difficile ribotype 033 strains.
Androga GO, McGovern AM, Elliott B, Chang BJ, Perkins TT, Foster NF, Riley TV. Androga GO, et al. J Clin Microbiol. 2015 Mar;53(3):973-5. doi: 10.1128/JCM.03297-14. Epub 2014 Dec 17. J Clin Microbiol. 2015. PMID: 25520452 Free PMC article.
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