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Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
Elliott PR, Lomas DA, Carrell RW, Abrahams JP. Elliott PR, et al. Nat Struct Biol. 1996 Aug;3(8):676-81. doi: 10.1038/nsb0896-676. Nat Struct Biol. 1996. PMID: 8756325
Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational disease.
Elliott PR, Pei XY, Dafforn TR, Lomas DA. Elliott PR, et al. Protein Sci. 2000 Jul;9(7):1274-81. doi: 10.1110/ps.9.7.1274. Protein Sci. 2000. PMID: 10933492 Free PMC article.
A kinetic mechanism for the polymerization of alpha1-antitrypsin.
Dafforn TR, Mahadeva R, Elliott PR, Sivasothy P, Lomas DA. Dafforn TR, et al. Among authors: elliott pr. J Biol Chem. 1999 Apr 2;274(14):9548-55. doi: 10.1074/jbc.274.14.9548. J Biol Chem. 1999. PMID: 10092640
Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema.
Elliott PR, Bilton D, Lomas DA. Elliott PR, et al. Am J Respir Cell Mol Biol. 1998 May;18(5):670-4. doi: 10.1165/ajrcmb.18.5.3065. Am J Respir Cell Mol Biol. 1998. PMID: 9569237
Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.
Elliott PR, Abrahams JP, Lomas DA. Elliott PR, et al. J Mol Biol. 1998 Jan 23;275(3):419-25. doi: 10.1006/jmbi.1997.1458. J Mol Biol. 1998. PMID: 9466920 Review.
Commercial plasma alpha1-antitrypsin (Prolastin) contains a conformationally inactive, latent component.
Lomas DA, Elliott PR, Carrell RW. Lomas DA, et al. Among authors: elliott pr. Eur Respir J. 1997 Mar;10(3):672-5. Eur Respir J. 1997. PMID: 9073003
Structural explanation for the deficiency of S alpha 1-antitrypsin.
Elliott PR, Stein PE, Bilton D, Carrell RW, Lomas DA. Elliott PR, et al. Nat Struct Biol. 1996 Nov;3(11):910-1. doi: 10.1038/nsb1196-910. Nat Struct Biol. 1996. PMID: 8901864 No abstract available.
alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.
Lomas DA, Elliott PR, Sidhar SK, Foreman RC, Finch JT, Cox DW, Whisstock JC, Carrell RW. Lomas DA, et al. Among authors: elliott pr. J Biol Chem. 1995 Jul 14;270(28):16864-70. doi: 10.1074/jbc.270.28.16864. J Biol Chem. 1995. PMID: 7622502
Preparation and characterization of latent alpha 1-antitrypsin.
Lomas DA, Elliott PR, Chang WS, Wardell MR, Carrell RW. Lomas DA, et al. Among authors: elliott pr. J Biol Chem. 1995 Mar 10;270(10):5282-8. doi: 10.1074/jbc.270.10.5282. J Biol Chem. 1995. PMID: 7890640
Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle.
Serena M, Bastos RN, Elliott PR, Barr FA. Serena M, et al. Among authors: elliott pr. J Cell Biol. 2020 Jul 6;219(7):e201910059. doi: 10.1083/jcb.201910059. J Cell Biol. 2020. PMID: 32356865 Free PMC article.
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