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Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria.
Weiss J, Elsbach P, Shu C, Castillo J, Grinna L, Horwitz A, Theofan G. Weiss J, et al. Among authors: Elsbach P. J Clin Invest. 1992 Sep;90(3):1122-30. doi: 10.1172/JCI115930. J Clin Invest. 1992. PMID: 1522221 Free PMC article.
TNF release induced by K. pneumoniae and P. aeruginosa was also inhibited by both holo-BPI and fragment but, at the protein concentrations tested, P. aeruginosa was killed only by the fragment and K. pneumoniae was not killed by either protein. ...
TNF release induced by K. pneumoniae and P. aeruginosa was also inhibited by both holo-BPI and fragment but, at the protein concentra …
High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide.
Gazzano-Santoro H, Parent JB, Grinna L, Horwitz A, Parsons T, Theofan G, Elsbach P, Weiss J, Conlon PJ. Gazzano-Santoro H, et al. Among authors: Elsbach P. Infect Immun. 1992 Nov;60(11):4754-61. Infect Immun. 1992. PMID: 1398985 Free PMC article.
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