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Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
Elsby R, Chidlaw S, Outteridge S, Pickering S, Radcliffe A, Sullivan R, Jones H, Butler P. Elsby R, et al. Pharmacol Res Perspect. 2017 Oct;5(5):e00357. doi: 10.1002/prp2.357. Pharmacol Res Perspect. 2017. PMID: 28971610 Free PMC article.
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