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Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.
Chu X, Korzekwa K, Elsby R, Fenner K, Galetin A, Lai Y, Matsson P, Moss A, Nagar S, Rosania GR, Bai JP, Polli JW, Sugiyama Y, Brouwer KL; International Transporter Consortium. Chu X, et al. Among authors: elsby r. Clin Pharmacol Ther. 2013 Jul;94(1):126-41. doi: 10.1038/clpt.2013.78. Epub 2013 Apr 10. Clin Pharmacol Ther. 2013. PMID: 23588320 Free PMC article. Review.
The use of bioreactors as in vitro models in pharmaceutical research.
Ginai M, Elsby R, Hewitt CJ, Surry D, Fenner K, Coopman K. Ginai M, et al. Among authors: elsby r. Drug Discov Today. 2013 Oct;18(19-20):922-35. doi: 10.1016/j.drudis.2013.05.016. Epub 2013 Jun 5. Drug Discov Today. 2013. PMID: 23748137 Review.
Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
Elsby R, Chidlaw S, Outteridge S, Pickering S, Radcliffe A, Sullivan R, Jones H, Butler P. Elsby R, et al. Pharmacol Res Perspect. 2017 Oct;5(5):e00357. doi: 10.1002/prp2.357. Pharmacol Res Perspect. 2017. PMID: 28971610 Free PMC article.
28 results