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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2005 3
2006 3
2007 5
2008 3
2009 1
2010 4
2011 10
2012 9
2013 6
2014 9
2015 14
2016 16
2017 11
2018 21
2019 20
2020 9
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Page 1
Emergent Functional Network Effects in Parkinson Disease.
Gratton C, Koller JM, Shannon W, Greene DJ, Maiti B, Snyder AZ, Petersen SE, Perlmutter JS, Campbell MC. Gratton C, et al. Cereb Cortex. 2019 Jun 1;29(6):2509-2523. doi: 10.1093/cercor/bhy121. Cereb Cortex. 2019. PMID: 29878081 Free PMC article.
The hallmark pathology underlying Parkinson disease (PD) is progressive synucleinopathy, beginning in caudal brainstem that later spreads rostrally. ...Overall, these results indicate a concerted breakdown of functional network interactions, remote fro …
The hallmark pathology underlying Parkinson disease (PD) is progressive synucleinopathy, beginning in caudal brainstem that la …
Emergent Functional Network Effects in Parkinson Disease.
Gratton C, Koller JM, Shannon W, Greene DJ, Maiti B, Snyder AZ, Petersen SE, Perlmutter JS, Campbell MC. Gratton C, et al. Cereb Cortex. 2019 Apr 1;29(4):1701. doi: 10.1093/cercor/bhy229. Cereb Cortex. 2019. PMID: 30418543 Free PMC article. No abstract available.
Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial.
Jankovic J, Goodman I, Safirstein B, Marmon TK, Schenk DB, Koller M, Zago W, Ness DK, Griffith SG, Grundman M, Soto J, Ostrowitzki S, Boess FG, Martin-Facklam M, Quinn JF, Isaacson SH, Omidvar O, Ellenbogen A, Kinney GG. Jankovic J, et al. JAMA Neurol. 2018 Oct 1;75(10):1206-1214. doi: 10.1001/jamaneurol.2018.1487. JAMA Neurol. 2018. PMID: 29913017 Free PMC article. Clinical Trial.
IMPORTANCE: Aggregated α-synuclein is believed to be central to the pathogenesis of Parkinson disease (PD). PRX002/RG7935 (PRX002) is a humanized monoclonal antibody designed to target aggregated forms of α-synuclein, thereby inhibiting neuron-to-neuron transfer of …
IMPORTANCE: Aggregated α-synuclein is believed to be central to the pathogenesis of Parkinson disease (PD). PRX002/RG7935 (PRX …
Gene therapy reduces Parkinson's disease symptoms by reorganizing functional brain connectivity.
Niethammer M, Tang CC, Vo A, Nguyen N, Spetsieris P, Dhawan V, Ma Y, Small M, Feigin A, During MJ, Kaplitt MG, Eidelberg D. Niethammer M, et al. Sci Transl Med. 2018 Nov 28;10(469):eaau0713. doi: 10.1126/scitranslmed.aau0713. Sci Transl Med. 2018. PMID: 30487248 Clinical Trial.
Gene therapy is emerging as a promising approach for treating neurological disorders, including Parkinson's disease (PD). A phase 2 clinical trial showed that delivering glutamic acid decarboxylase (GAD) into the subthalamic nucleus (STN) of patients w …
Gene therapy is emerging as a promising approach for treating neurological disorders, including Parkinson's disease
Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease.
Jastrzębowska MA, Marquis R, Melie-García L, Lutti A, Kherif F, Herzog MH, Draganski B. Jastrzębowska MA, et al. Hum Brain Mapp. 2019 Oct 15;40(15):4397-4416. doi: 10.1002/hbm.24710. Epub 2019 Jul 10. Hum Brain Mapp. 2019. PMID: 31291039 Free PMC article.
The dopaminergic system has a unique gating function in the initiation and execution of movements. When the interhemispheric imbalance of dopamine inherent to the healthy brain is disrupted, as in Parkinson's disease (PD), compensatory mechanisms act t …
The dopaminergic system has a unique gating function in the initiation and execution of movements. When the interhemispheric imbalanc …
Unmasking levodopa resistance in Parkinson's disease.
Nonnekes J, Timmer MH, de Vries NM, Rascol O, Helmich RC, Bloem BR. Nonnekes J, et al. Mov Disord. 2016 Nov;31(11):1602-1609. doi: 10.1002/mds.26712. Epub 2016 Jul 19. Mov Disord. 2016. PMID: 27430479 Review.
Some motor and nonmotor features associated with Parkinson's disease (PD) do not seem to respond well to levodopa (or other forms of dopaminergic medication) or appear to become resistant to levodopa treatment with disease progression and longer dis
Some motor and nonmotor features associated with Parkinson's disease (PD) do not seem to respond well to levodopa (or o …
Sleep as a Therapeutic Target in the Aging Brain.
Bah TM, Goodman J, Iliff JJ. Bah TM, et al. Neurotherapeutics. 2019 Jul;16(3):554-568. doi: 10.1007/s13311-019-00769-6. Neurotherapeutics. 2019. PMID: 31376067 Free PMC article. Review.
Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be ca …
Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's dis
Pallidal thermolesion unleashes gamma oscillations in the motor cortex in Parkinson's disease.
de Hemptinne C, Wang DD, Miocinovic S, Chen W, Ostrem JL, Starr PA. de Hemptinne C, et al. Mov Disord. 2019 Jun;34(6):903-911. doi: 10.1002/mds.27658. Epub 2019 Mar 13. Mov Disord. 2019. PMID: 30868646
BACKGROUND: In Parkinson's disease, the emergence of motor dysfunction is thought to be related to an imbalance between "antikinetic" and "prokinetic" patterns of oscillatory activity in the motor network. ...RESULTS: In all 3 Parkinson' …
BACKGROUND: In Parkinson's disease, the emergence of motor dysfunction is thought to be related to an imbalance …
Deep brain stimulation: potential for neuroprotection.
McKinnon C, Gros P, Lee DJ, Hamani C, Lozano AM, Kalia LV, Kalia SK. McKinnon C, et al. Ann Clin Transl Neurol. 2018 Nov 8;6(1):174-185. doi: 10.1002/acn3.682. eCollection 2019 Jan. Ann Clin Transl Neurol. 2018. PMID: 30656196 Free PMC article. Review.
Novel applications of DBS continue to emerge including treatment of various psychiatric conditions (e.g. obsessive-compulsive disorder, major depression) and cognitive disorders such as Alzheimer's disease. ...In this review, we consider evidence from preclin …
Novel applications of DBS continue to emerge including treatment of various psychiatric conditions (e.g. obsessive-compulsive disorde …
Abnormal Phase Coupling in Parkinson's Disease and Normalization Effects of Subthreshold Vestibular Stimulation.
Lee S, Liu A, Wang ZJ, McKeown MJ. Lee S, et al. Front Hum Neurosci. 2019 Apr 3;13:118. doi: 10.3389/fnhum.2019.00118. eCollection 2019. Front Hum Neurosci. 2019. PMID: 31001099 Free PMC article.
Emerging perspectives on basal ganglia (BG) and thalamic functions have highlighted their role in facilitating and mediating information transmission among cortical regions. ...In this work, we identified EEG-based altered resting-state cortical functional co
Emerging perspectives on basal ganglia (BG) and thalamic functions have highlighted their role in facilitating and mediating i
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