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2004 1
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Aerobic Exercise Alters Brain Function and Structure in Parkinson's Disease: A Randomized Controlled Trial.
Johansson ME, Cameron IGM, Van der Kolk NM, de Vries NM, Klimars E, Toni I, Bloem BR, Helmich RC. Johansson ME, et al. Ann Neurol. 2022 Feb;91(2):203-216. doi: 10.1002/ana.26291. Epub 2022 Jan 19. Ann Neurol. 2022. PMID: 34951063 Free PMC article. Clinical Trial.
OBJECTIVE: Randomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's disease, but the underlying neural mechanisms are unclear. Here, we investigated how aerobic exercise influences disease-related …
OBJECTIVE: Randomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's …
Blood-based biomarkers for Alzheimer's disease: towards clinical implementation.
Teunissen CE, Verberk IMW, Thijssen EH, Vermunt L, Hansson O, Zetterberg H, van der Flier WM, Mielke MM, Del Campo M. Teunissen CE, et al. Lancet Neurol. 2022 Jan;21(1):66-77. doi: 10.1016/S1474-4422(21)00361-6. Epub 2021 Nov 24. Lancet Neurol. 2022. PMID: 34838239 Review.
For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but recent results have shown that they could become a reality. ...This step would pave the way for blood-based biomarkers to support the diagnosis of, and development of treatments …
For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but recent results have shown that they co …
Emergent Functional Network Effects in Parkinson Disease.
Gratton C, Koller JM, Shannon W, Greene DJ, Maiti B, Snyder AZ, Petersen SE, Perlmutter JS, Campbell MC. Gratton C, et al. Cereb Cortex. 2019 Jun 1;29(6):2509-2523. doi: 10.1093/cercor/bhy121. Cereb Cortex. 2019. PMID: 29878081 Free PMC article.
The hallmark pathology underlying Parkinson disease (PD) is progressive synucleinopathy, beginning in caudal brainstem that later spreads rostrally. ...We employed novel statistical approaches to determine group differences across the entire connectome, at the ne …
The hallmark pathology underlying Parkinson disease (PD) is progressive synucleinopathy, beginning in caudal brainstem that la …
MRI biomarkers of motor and non-motor symptoms in Parkinson's disease.
Ryman SG, Poston KL. Ryman SG, et al. Parkinsonism Relat Disord. 2020 Apr;73:85-93. doi: 10.1016/j.parkreldis.2019.10.002. Epub 2019 Oct 10. Parkinsonism Relat Disord. 2020. PMID: 31629653 Free PMC article. Review.
Parkinson's disease is a heterogeneous disorder with both motor and non-motor symptoms that contribute to functional impairment. ...Iron, neuromelanin, and diffusion sensitive measures demonstrate high specificity and sensitivity in distinguishing P …
Parkinson's disease is a heterogeneous disorder with both motor and non-motor symptoms that contribute to functional …
Emergent Functional Network Effects in Parkinson Disease.
Gratton C, Koller JM, Shannon W, Greene DJ, Maiti B, Snyder AZ, Petersen SE, Perlmutter JS, Campbell MC. Gratton C, et al. Cereb Cortex. 2019 Apr 1;29(4):1701. doi: 10.1093/cercor/bhy229. Cereb Cortex. 2019. PMID: 30418543 Free PMC article. No abstract available.
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P; GenOMICC Investigators; SCOURGE Consortium; ISARICC Investigators; 23andMe COVID-19 Team; Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK. Pairo-Castineira E, et al. Nature. 2023 May;617(7962):764-768. doi: 10.1038/s41586-023-06034-3. Epub 2023 May 17. Nature. 2023. PMID: 37198478 Free PMC article.
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown(1) to be highly efficient for discovery of genetic associations(2). Despite the advanced stage of illness at presentation, we have shown that host genetics …
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown(1) to be highly …
A saturated map of common genetic variants associated with human height.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, Spracklen CN, Yin X, Chen SH, Ferreira T, Highland HH, Ji Y, Karaderi T, Lin K, Lüll K, Malden DE, Medina-Gomez C, Machado M, Moore A, Rüeger S, Sim X, Vrieze S, Ahluwalia TS, Akiyama M, Allison MA, Alvarez M, Andersen MK, Ani A, Appadurai V, Arbeeva L, Bhaskar S, Bielak LF, Bollepalli S, Bonnycastle LL, Bork-Jensen J, Bradfield JP, Bradford Y, Braund PS, Brody JA, Burgdorf KS, Cade BE, Cai H, Cai Q, Campbell A, Cañadas-Garre M, Catamo E, Chai JF, Chai X, Chang LC, Chang YC, Chen CH, Chesi A, Choi SH, Chung RH, Cocca M, Concas MP, Couture C, Cuellar-Partida G, Danning R, Daw EW, Degenhard F, Delgado GE, Delitala A, Demirkan A, Deng X, Devineni P, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Ekici AB, Engmann JE, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Francescatto M, Freitag-Wolf S, Fuchsberger C, Galesloot TE, Gao Y, Gao Z, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, He J, Heard-Costa N, … See abstract for full author list ➔ Yengo L, et al. Nature. 2022 Oct;610(7933):704-712. doi: 10.1038/s41586-022-05275-y. Epub 2022 Oct 12. Nature. 2022. PMID: 36224396 Free PMC article.
In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated …
In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic varia …
Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders.
Horn J, Mayer DE, Chen S, Mayer EA. Horn J, et al. Transl Psychiatry. 2022 Apr 20;12(1):164. doi: 10.1038/s41398-022-01922-0. Transl Psychiatry. 2022. PMID: 35443740 Free PMC article. Review.
There is emerging evidence that diet has a major modulatory influence on brain-gut-microbiome (BGM) interactions with important implications for brain health, and for several brain disorders. ...Diet not only plays a crucial role in shaping the gut microbiome, but it can m …
There is emerging evidence that diet has a major modulatory influence on brain-gut-microbiome (BGM) interactions with important impli …
Acute effects of adaptive Deep Brain Stimulation in Parkinson's disease.
Piña-Fuentes D, van Dijk JMC, van Zijl JC, Moes HR, van Laar T, Oterdoom DLM, Little S, Brown P, Beudel M. Piña-Fuentes D, et al. Brain Stimul. 2020 Nov-Dec;13(6):1507-1516. doi: 10.1016/j.brs.2020.07.016. Epub 2020 Jul 29. Brain Stimul. 2020. PMID: 32738409 Free PMC article.
BACKGROUND: Beta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson's disease (PD), when assessed in the immediate post-implantation phase. ...Patient videos were blindly evaluated using a short version of the Unified Parkinson …
BACKGROUND: Beta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson's disease (PD), when ass …
Unmasking levodopa resistance in Parkinson's disease.
Nonnekes J, Timmer MH, de Vries NM, Rascol O, Helmich RC, Bloem BR. Nonnekes J, et al. Mov Disord. 2016 Nov;31(11):1602-1609. doi: 10.1002/mds.26712. Epub 2016 Jul 19. Mov Disord. 2016. PMID: 27430479 Review.
Some motor and nonmotor features associated with Parkinson's disease (PD) do not seem to respond well to levodopa (or other forms of dopaminergic medication) or appear to become resistant to levodopa treatment with disease progression and longer dis …
Some motor and nonmotor features associated with Parkinson's disease (PD) do not seem to respond well to levodopa (or o …
182 results