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High dimensional profiling identifies specific immune types along the recovery trajectories of critically ill COVID19 patients.
Penttilä PA, Van Gassen S, Panovska D, Vanderbeke L, Van Herck Y, Quintelier K, Emmaneel A, Filtjens J, Malengier-Devlies B, Ahmadzadeh K, Van Mol P, Borràs DM, Antoranz A, Bosisio FM, Wauters E, Martinod K, Matthys P, Saeys Y, Garg AD, Wauters J, De Smet F; CONTAGIOUS consortium. Penttilä PA, et al. Among authors: emmaneel a. Cell Mol Life Sci. 2021 Apr;78(8):3987-4002. doi: 10.1007/s00018-021-03808-8. Epub 2021 Mar 13. Cell Mol Life Sci. 2021. PMID: 33715015 Free PMC article.
A Computational Pipeline for the Diagnosis of CVID Patients.
Emmaneel A, Bogaert DJ, Van Gassen S, Tavernier SJ, Dullaers M, Haerynck F, Saeys Y. Emmaneel A, et al. Front Immunol. 2019 Aug 30;10:2009. doi: 10.3389/fimmu.2019.02009. eCollection 2019. Front Immunol. 2019. PMID: 31543876 Free PMC article.
Analyzing high-dimensional cytometry data using FlowSOM.
Quintelier K, Couckuyt A, Emmaneel A, Aerts J, Saeys Y, Van Gassen S. Quintelier K, et al. Among authors: emmaneel a. Nat Protoc. 2021 Aug;16(8):3775-3801. doi: 10.1038/s41596-021-00550-0. Epub 2021 Jun 25. Nat Protoc. 2021. PMID: 34172973 Review.
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.
Vanderbeke L, Van Mol P, Van Herck Y, De Smet F, Humblet-Baron S, Martinod K, Antoranz A, Arijs I, Boeckx B, Bosisio FM, Casaer M, Dauwe D, De Wever W, Dooms C, Dreesen E, Emmaneel A, Filtjens J, Gouwy M, Gunst J, Hermans G, Jansen S, Lagrou K, Liston A, Lorent N, Meersseman P, Mercier T, Neyts J, Odent J, Panovska D, Penttila PA, Pollet E, Proost P, Qian J, Quintelier K, Raes J, Rex S, Saeys Y, Sprooten J, Tejpar S, Testelmans D, Thevissen K, Van Buyten T, Vandenhaute J, Van Gassen S, Velásquez Pereira LC, Vos R, Weynand B, Wilmer A, Yserbyt J, Garg AD, Matthys P, Wouters C, Lambrechts D, Wauters E, Wauters J. Vanderbeke L, et al. Among authors: emmaneel a. Nat Commun. 2021 Jul 5;12(1):4117. doi: 10.1038/s41467-021-24360-w. Nat Commun. 2021. PMID: 34226537 Free PMC article.
PeacoQC: Peak-based selection of high quality cytometry data.
Emmaneel A, Quintelier K, Sichien D, Rybakowska P, Marañón C, Alarcón-Riquelme ME, Van Isterdael G, Van Gassen S, Saeys Y. Emmaneel A, et al. Cytometry A. 2022 Apr;101(4):325-338. doi: 10.1002/cyto.a.24501. Epub 2021 Oct 3. Cytometry A. 2022. PMID: 34549881 Free PMC article.
Challenges in translational machine learning.
Couckuyt A, Seurinck R, Emmaneel A, Quintelier K, Novak D, Van Gassen S, Saeys Y. Couckuyt A, et al. Among authors: emmaneel a. Hum Genet. 2022 Sep;141(9):1451-1466. doi: 10.1007/s00439-022-02439-8. Epub 2022 Mar 4. Hum Genet. 2022. PMID: 35246744 Free PMC article. Review.
The Euroflow PID Orientation Tube in the diagnostic workup of primary immunodeficiency: Daily practice performance in a tertiary university hospital.
Neirinck J, Emmaneel A, Buysse M, Philippé J, Van Gassen S, Saeys Y, Bossuyt X, De Buyser S, van der Burg M, Pérez-Andrés M, Orfao A, van Dongen JJM, Lambrecht BN, Kerre T, Hofmans M, Haerynck F, Bonroy C. Neirinck J, et al. Among authors: emmaneel a. Front Immunol. 2022 Sep 13;13:937738. doi: 10.3389/fimmu.2022.937738. eCollection 2022. Front Immunol. 2022. PMID: 36177024 Free PMC article.
LXR signaling controls homeostatic dendritic cell maturation.
Bosteels V, Maréchal S, De Nolf C, Rennen S, Maelfait J, Tavernier SJ, Vetters J, Van De Velde E, Fayazpour F, Deswarte K, Lamoot A, Van Duyse J, Martens L, Bosteels C, Roelandt R, Emmaneel A, Van Gassen S, Boon L, Van Isterdael G, Guillas I, Vandamme N, Höglinger D, De Geest BG, Le Goff W, Saeys Y, Ravichandran KS, Lambrecht BN, Janssens S. Bosteels V, et al. Among authors: emmaneel a. Sci Immunol. 2023 May 12;8(83):eadd3955. doi: 10.1126/sciimmunol.add3955. Epub 2023 May 12. Sci Immunol. 2023. PMID: 37172103