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The alpha-toxin of Clostridium septicum is essential for virulence.
Kennedy CL, Krejany EO, Young LF, O'Connor JR, Awad MM, Boyd RL, Emmins JJ, Lyras D, Rood JI. Kennedy CL, et al. Among authors: emmins jj. Mol Microbiol. 2005 Sep;57(5):1357-66. doi: 10.1111/j.1365-2958.2005.04774.x. Mol Microbiol. 2005. PMID: 16102005 Free article.
The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence.
Chiarezza M, Lyras D, Pidot SJ, Flores-Díaz M, Awad MM, Kennedy CL, Cordner LM, Phumoonna T, Poon R, Hughes ML, Emmins JJ, Alape-Girón A, Rood JI. Chiarezza M, et al. Among authors: emmins jj. Infect Immun. 2009 Oct;77(10):4421-8. doi: 10.1128/IAI.00548-09. Epub 2009 Aug 3. Infect Immun. 2009. PMID: 19651873 Free PMC article.