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The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2.
Otsu W, Hsu YC, Chuang JZ, Sung CH. Otsu W, et al. J Neurosci. 2019 May 1;39(18):3376-3393. doi: 10.1523/JNEUROSCI.2811-18.2019. Epub 2019 Feb 28. J Neurosci. 2019. PMID: 30819798 Free PMC article.
Peripherin 2 (PRPH2) is a tetraspanin protein concentrated in the light-sensing cilium (called the outer segment) of the vertebrate photoreceptor. ...The mechanism underlying the ciliary transport of PRPH2 is unclear. The present study reveals a
Peripherin 2 (PRPH2) is a tetraspanin protein concentrated in the light-sensing cilium (called the outer segment
[Role of endosomal pathway in the ciliary transport and the membrane organization of outer segment disc membrane in photoreceptors].
Otsu W. Otsu W. Nihon Yakurigaku Zasshi. 2024 Apr 26. doi: 10.1254/fpj.23077. Online ahead of print. Nihon Yakurigaku Zasshi. 2024. PMID: 38684400 Japanese.
The multiple C-terminal motifs of PRPH2 regulate its late endosome and ciliary targeting through ubiquitination and binding to an Endosomal Sorting Complexes Required for Transport (ESCRT) component, Hrs. These findings suggest that the late …
The multiple C-terminal motifs of PRPH2 regulate its late endosome and ciliary targeting through ubiquitination …