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Trimetazidine in cardiovascular medicine.
Marzilli M, Vinereanu D, Lopaschuk G, Chen Y, Dalal JJ, Danchin N, Etriby E, Ferrari R, Gowdak LH, Lopatin Y, Milicic D, Parkhomenko A, Pinto F, Ponikowski P, Seferovic P, Rosano GMC. Marzilli M, et al. Int J Cardiol. 2019 Oct 15;293:39-44. doi: 10.1016/j.ijcard.2019.05.063. Epub 2019 May 24. Int J Cardiol. 2019. PMID: 31178223 Review.
Abnormalities of myocardial energy metabolism appear as a common background of the two major cardiac disorders: ischemic heart disease (IHD) and heart failure (HF). ...The impact of TMZ on long term mortality and morbidity in ischemic syndromes …
Abnormalities of myocardial energy metabolism appear as a common background of the two major cardiac disorders: ischemic he
Metabolic therapy of heart failure.
Fragasso G, Salerno A, Spoladore R, Bassanelli G, Arioli F, Margonato A. Fragasso G, et al. Curr Pharm Des. 2008;14(25):2582-91. doi: 10.2174/138161208786071245. Curr Pharm Des. 2008. PMID: 18991675 Review.
A direct approach to manipulate cardiac energy metabolism consists in modifying substrate utilization by the failing heart. ...However, the results of current research is supporting the concept that shifting the energy substrate preference away from fa …
A direct approach to manipulate cardiac energy metabolism consists in modifying substrate utilization by the failing heart
Metabolic abnormalities of the heart in type II diabetes.
Amaral N, Okonko DO. Amaral N, et al. Diab Vasc Dis Res. 2015 Jul;12(4):239-48. doi: 10.1177/1479164115580936. Epub 2015 May 4. Diab Vasc Dis Res. 2015. PMID: 25941161 Free article. Review.
Type 2 diabetes mellitus escalates the risk of heart failure partly via its ability to induce a cardiomyopathic state that is independent of coronary artery disease and hypertension. Although the pathogenesis of diabetic cardiomyopathy has yet t …
Type 2 diabetes mellitus escalates the risk of heart failure partly via its ability to induce a cardiomyopathic …
Early administration of trimetazidine may prevent or ameliorate diabetic cardiomyopathy.
Wenmeng W, Qizhu T. Wenmeng W, et al. Med Hypotheses. 2011 Feb;76(2):181-3. doi: 10.1016/j.mehy.2010.09.012. Epub 2010 Oct 6. Med Hypotheses. 2011. PMID: 20932648
It clinically manifests initially as asymptomatic diastolic dysfunction and then progresses to symptomatic heart failure. Two major contributors to the development of diabetic cardiomyopathy, which are unique to diabetes, are hyperglycemia and diabe
It clinically manifests initially as asymptomatic diastolic dysfunction and then progresses to symptomatic heart failure. Two …
Metabolic therapy for patients with diabetes mellitus and coronary artery disease.
Rosano GM, Vitale C, Fragasso G. Rosano GM, et al. Am J Cardiol. 2006 Sep 4;98(5A):14J-18J. doi: 10.1016/j.amjcard.2006.07.004. Epub 2006 Jul 24. Am J Cardiol. 2006. PMID: 16931201 Review.
Patients with diabetes mellitus and ischemic heart disease more frequently develop heart failure and have a greater amount of myocardial ischemia, often silent, compared with patients without diabetes. ...In patients with diabetes, …
Patients with diabetes mellitus and ischemic heart disease more frequently develop heart failure and have …
Modulation of fatty acids oxidation in heart failure by selective pharmacological inhibition of 3-ketoacyl coenzyme-A thiolase.
Fragasso G, Spoladore R, Cuko A, Palloshi A. Fragasso G, et al. Curr Clin Pharmacol. 2007 Sep;2(3):190-6. doi: 10.2174/157488407781668776. Curr Clin Pharmacol. 2007. PMID: 18690865 Review.
A direct approach to manipulate cardiac energy metabolism consists in modifying substrate utilization by the heart. ...However, the results of current research is also supporting the concept that shifting the energy substrate preference away from fatty …
A direct approach to manipulate cardiac energy metabolism consists in modifying substrate utilization by the heart. ... …
Effects of metabolic approach in diabetic patients with coronary artery disease.
Fragasso G, Salerno A, Spoladore R, Cera M, Montanaro C, Margonato A. Fragasso G, et al. Curr Pharm Des. 2009;15(8):857-62. doi: 10.2174/138161209787582093. Curr Pharm Des. 2009. PMID: 19275650 Review.
The increased uptake and utilization of free fatty acid and the reduced utilization of glucose as source of energy during stress and ischemia are responsible for the increased susceptibility of the diabetic heart to myocardial ischemia and to a greater decrea …
The increased uptake and utilization of free fatty acid and the reduced utilization of glucose as source of energy during stress and …
["Persistent" angina: rationale for a metabolic approach].
Marzilli M. Marzilli M. Ital Heart J. 2004 Mar;5 Suppl 2:37S-41S. Ital Heart J. 2004. PMID: 15074776 Review. Italian.
Tailoring therapy to individual needs has become even more challenging because of the marked changes in the clinical profile of patients with chronic ischemic heart disease. Compared with the past, today's patients tend to be older, to have undergone revascularization proc …
Tailoring therapy to individual needs has become even more challenging because of the marked changes in the clinical profile of patients wit …
Clinical benefits of a metabolic approach in the management of coronary patients.
Marzilli M. Marzilli M. Rev Port Cardiol. 2000 Nov;19 Suppl 5:V25-30. Rev Port Cardiol. 2000. PMID: 11206100 Review.
More recently, Trimetazidine has been shown to improve left ventricular dysfunction in patients with congestive heart failure, and in ischemic patients undergoing PTCA. ...Given the metabolic mechanism of action of Trimetazidine, focused on improving …
More recently, Trimetazidine has been shown to improve left ventricular dysfunction in patients with congestive heart failu
[Modifications in myocardial energy metabolism in diabetic patients]].
Grynberg A. Grynberg A. Diabetes Metab. 2001 Nov;27(5 Pt 2):S12-9. Diabetes Metab. 2001. PMID: 11910980 French.
The diabetic heart being characterised by a different metabolic "status" with similarities to that of myocardium in coronary disease. Diabetes and other chronic cardiac diseases share common FA metabolism disorders leading to an altered energy b …
The diabetic heart being characterised by a different metabolic "status" with similarities to that of myocardium in coronary d …
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