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A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. Doyle PS, et al. Among authors: engel jc. Antimicrob Agents Chemother. 2010 Jun;54(6):2480-8. doi: 10.1128/AAC.00281-10. Epub 2010 Apr 12. Antimicrob Agents Chemother. 2010. PMID: 20385875 Free PMC article.
The Trypanosoma cruzi protease cruzain mediates immune evasion.
Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. Doyle PS, et al. Among authors: engel jc. PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1. PLoS Pathog. 2011. PMID: 21909255 Free PMC article.
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.
Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Gunatilleke SS, et al. Among authors: engel jc. PLoS Negl Trop Dis. 2012;6(7):e1736. doi: 10.1371/journal.pntd.0001736. Epub 2012 Jul 31. PLoS Negl Trop Dis. 2012. PMID: 22860142 Free PMC article.
Drugs targeting parasite lysosomes.
Doyle PS, Sajid M, O'Brien T, Dubois K, Engel JC, Mackey ZB, Reed S. Doyle PS, et al. Among authors: engel jc. Curr Pharm Des. 2008;14(9):889-900. doi: 10.2174/138161208784041060. Curr Pharm Des. 2008. PMID: 18473838 Review.
74 results