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Chemical synthesis of 2'-O-alkylated siRNAs.
Engels JW, Odadzic D, Smicius R, Haas J. Engels JW, et al. Methods Mol Biol. 2010;623:155-70. doi: 10.1007/978-1-60761-588-0_10. Methods Mol Biol. 2010. PMID: 20217550
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjaer N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: engels jw. Nucleic Acids Res. 2009 May;37(9):2867-81. doi: 10.1093/nar/gkp106. Epub 2009 Mar 12. Nucleic Acids Res. 2009. PMID: 19282453 Free PMC article.
RNA recognition by fluor-aromatic substituted.
Zivković A, Engels JW. Zivković A, et al. Among authors: engels jw. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1023-7. doi: 10.1081/ncn-200059755. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16248084
147 results