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The Definition and Prevalence of Obesity and Metabolic Syndrome.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:1-17. doi: 10.1007/978-3-319-48382-5_1. Adv Exp Med Biol. 2017. PMID: 28585193 Review.
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. ...The average prevalence of metabolic syndrome is 31%, and is associated with a two-fold increase in the risk of coronary heart disea …
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. . …
The effect of adipocyte-macrophage crosstalk in obesity-related breast cancer.
Engin AB, Engin A, Gonul II. Engin AB, et al. J Mol Endocrinol. 2019 Apr 1;62(3):R201-R222. doi: 10.1530/JME-18-0252. J Mol Endocrinol. 2019. PMID: 30620711 Review.
Free fatty acid and tumor necrosis factor-α involve in a vicious cycle between adipocytes and macrophages aggravating inflammatory changes. Thereby, M1 macrophages form a characteristic 'crown-like structure (CLS)' around necrotic adipocytes in obese adipose tissue. …
Free fatty acid and tumor necrosis factor-α involve in a vicious cycle between adipocytes and macrophages aggravating inflammatory ch …
Do flavanols-rich natural products relieve obesity-related insulin resistance?
Engin AB, Tsatsakis AM, Tsoukalas D, Engin A. Engin AB, et al. Food Chem Toxicol. 2018 Feb;112:157-167. doi: 10.1016/j.fct.2017.12.055. Epub 2017 Dec 27. Food Chem Toxicol. 2018. PMID: 29288757 Review.
Growing evidence support that insulin resistance may occur as a severe problem due to chronic energetic overfeeding and subsequent obesity. ...In this context, excessive hepatic lipid accumulation may play a central, pathogenic role in insulin resistance. It is thou …
Growing evidence support that insulin resistance may occur as a severe problem due to chronic energetic overfeeding and subsequent ob …
Obesity-associated Breast Cancer: Analysis of risk factors.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:571-606. doi: 10.1007/978-3-319-48382-5_25. Adv Exp Med Biol. 2017. PMID: 28585217 Review.
Several studies show that a significantly stronger association is obvious between increased body mass index (BMI) and higher breast cancer incidence. ...While higher breast cancer risk with hormone replacement therapy is particularly evident among lean women, in postmenopa …
Several studies show that a significantly stronger association is obvious between increased body mass index (BMI) and higher breast c …
Does Bariatric Surgery Improve Obesity Associated Comorbid Conditions.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:545-570. doi: 10.1007/978-3-319-48382-5_24. Adv Exp Med Biol. 2017. PMID: 28585216 Review.
Obesity is a constantly growing health problem which reduces quality of life and life expectancy. Bariatric surgery for obesity is taken into account when all other conservative treatment modalities have failed. ...
Obesity is a constantly growing health problem which reduces quality of life and life expectancy. Bariatric surgery for obesity is ta …
Non-Alcoholic Fatty Liver Disease.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:443-467. doi: 10.1007/978-3-319-48382-5_19. Adv Exp Med Biol. 2017. PMID: 28585211 Review.
Furthermore, hepatocyte lipoapoptosis is a critical feature of NASH. In "second hit" reduced glutathione levels due to oxidative stress lead to overactivation of c-Jun N-terminal kinase (JNK)/c-Jun signaling that induces cell death in the steatotic liver. ...
Furthermore, hepatocyte lipoapoptosis is a critical feature of NASH. In "second hit" reduced glutathione levels due to oxidative stre …
Adiponectin-Resistance in Obesity.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:415-441. doi: 10.1007/978-3-319-48382-5_18. Adv Exp Med Biol. 2017. PMID: 28585210 Review.
Actually, adiponectin resistance occurs very rapidly after saturated fatty acid feeding, this metabolic disturbance is not due to a decrease in AdipoR1 protein content. ...Adiponectin resistance together with insulin resistance forms a vicious cycle. The elevated ad …
Actually, adiponectin resistance occurs very rapidly after saturated fatty acid feeding, this metabolic disturbance is not due to a d …
Diet-Induced Obesity and the Mechanism of Leptin Resistance.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:381-397. doi: 10.1007/978-3-319-48382-5_16. Adv Exp Med Biol. 2017. PMID: 28585208 Review.
Although, long form leptin receptor (Ob-Rb) initiates leptin signaling through more than seven different signal transduction pathways, excessive suppressor of cytokine signaling-3 (SOCS-3) activity is a potential mechanism for the leptin resistance that characterizes human …
Although, long form leptin receptor (Ob-Rb) initiates leptin signaling through more than seven different signal transduction pathways, exces …
Endothelial Dysfunction in Obesity.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:345-379. doi: 10.1007/978-3-319-48382-5_15. Adv Exp Med Biol. 2017. PMID: 28585207 Review.
While normal healthy perivascular adipose tissue (PVAT) ensures the dilation of blood vessels, obesity-associated PVAT leads to a change in profile of the released adipo-cytokines, resulting in a decreased vasorelaxing effect. ...
While normal healthy perivascular adipose tissue (PVAT) ensures the dilation of blood vessels, obesity-associated PVAT leads to a cha …
Adipose Tissue Hypoxia in Obesity and Its Impact on Preadipocytes and Macrophages: Hypoxia Hypothesis.
Engin A. Engin A. Adv Exp Med Biol. 2017;960:305-326. doi: 10.1007/978-3-319-48382-5_13. Adv Exp Med Biol. 2017. PMID: 28585205 Review.
Hypoxia affects a number of biological functions, such as angiogenesis, cell proliferation, apoptosis, inflammation and insulin resistance. ...
Hypoxia affects a number of biological functions, such as angiogenesis, cell proliferation, apoptosis, inflammation and insulin resis …
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