Engin HB - Search Results

1

MHC-I Genotype Restricts the Oncogenic Mutational Landscape.

Marty R, Kaabinejadian S, Rossell D, Slifker MJ, van de Haar J, Engin HB, de Prisco N, Ideker T, Hildebrand WH, Font-Burgada J, Carter H. Marty R, et al. Among authors: engin hb. Cell. 2017 Nov 30;171(6):1272-1283.e15. doi: 10.1016/j.cell.2017.09.050. Epub 2017 Oct 26. Cell. 2017. PMID: 29107334 Free PMC article.

2

Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces.

Engin HB, Kreisberg JF, Carter H. Engin HB, et al. PLoS One. 2016 Apr 4;11(4):e0152929. doi: 10.1371/journal.pone.0152929. eCollection 2016. PLoS One. 2016. PMID: 27043210 Free PMC article.

3

Identifying mutation specific cancer pathways using a structurally resolved protein interaction network.

Engin HB, Hofree M, Carter H. Engin HB, et al. Pac Symp Biocomput. 2015;20:84-95. Pac Symp Biocomput. 2015. PMID: 25592571 Free PMC article.

4

Modeling of RAS complexes supports roles in cancer for less studied partners.

Engin HB, Carlin D, Pratt D, Carter H. Engin HB, et al. BMC Biophys. 2017 Aug 11;10(Suppl 1):5. doi: 10.1186/s13628-017-0037-6. eCollection 2017. BMC Biophys. 2017. PMID: 28815022 Free PMC article.

5

Glioblastomas located in proximity to the subventricular zone (SVZ) exhibited enrichment of gene expression profiles associated with the cancer stem cell state.

Steed TC, Treiber JM, Taha B, Engin HB, Carter H, Patel KS, Dale AM, Carter BS, Chen CC. Steed TC, et al. Among authors: engin hb. J Neurooncol. 2020 Jul;148(3):455-462. doi: 10.1007/s11060-020-03550-4. Epub 2020 Jun 15. J Neurooncol. 2020. PMID: 32556864

6

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.

Menden MP, Wang D, Mason MJ, Szalai B, Bulusu KC, Guan Y, Yu T, Kang J, Jeon M, Wolfinger R, Nguyen T, Zaslavskiy M; AstraZeneca-Sanger Drug Combination DREAM Consortium; Jang IS, Ghazoui Z, Ahsen ME, Vogel R, Neto EC, Norman T, Tang EKY, Garnett MJ, Veroli GYD, Fawell S, Stolovitzky G, Guinney J, Dry JR, Saez-Rodriguez J. Menden MP, et al. Nat Commun. 2019 Jun 17;10(1):2674. doi: 10.1038/s41467-019-09799-2. Nat Commun. 2019. PMID: 31209238 Free PMC article.

7

Integrating structure to protein-protein interaction networks that drive metastasis to brain and lung in breast cancer.

Engin HB, Guney E, Keskin O, Oliva B, Gursoy A. Engin HB, et al. PLoS One. 2013 Nov 22;8(11):e81035. doi: 10.1371/journal.pone.0081035. eCollection 2013. PLoS One. 2013. PMID: 24278371 Free PMC article.

8

Hot spots in protein-protein interfaces: towards drug discovery.

Cukuroglu E, Engin HB, Gursoy A, Keskin O. Cukuroglu E, et al. Among authors: engin hb. Prog Biophys Mol Biol. 2014 Nov-Dec;116(2-3):165-73. doi: 10.1016/j.pbiomolbio.2014.06.003. Epub 2014 Jul 2. Prog Biophys Mol Biol. 2014. PMID: 24997383 Review.

9

A strategy based on protein-protein interface motifs may help in identifying drug off-targets.

Engin HB, Keskin O, Nussinov R, Gursoy A. Engin HB, et al. J Chem Inf Model. 2012 Aug 27;52(8):2273-86. doi: 10.1021/ci300072q. Epub 2012 Jul 31. J Chem Inf Model. 2012. PMID: 22817115 Free PMC article.

10

Network-based strategies can help mono- and poly-pharmacology drug discovery: a systems biology view.

Engin HB, Gursoy A, Nussinov R, Keskin O. Engin HB, et al. Curr Pharm Des. 2014;20(8):1201-7. doi: 10.2174/13816128113199990066. Curr Pharm Des. 2014. PMID: 23713773 Review.

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