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Matrix elasticity directs stem cell lineage specification.
Engler AJ, Sen S, Sweeney HL, Discher DE. Engler AJ, et al. Cell. 2006 Aug 25;126(4):677-89. doi: 10.1016/j.cell.2006.06.044. Cell. 2006. PMID: 16923388
Intrinsic extracellular matrix properties regulate stem cell differentiation.
Reilly GC, Engler AJ. Reilly GC, et al. J Biomech. 2010 Jan 5;43(1):55-62. doi: 10.1016/j.jbiomech.2009.09.009. Epub 2009 Oct 2. J Biomech. 2010. PMID: 19800626 Review.
Interplay of matrix stiffness and protein tethering in stem cell differentiation.
Wen JH, Vincent LG, Fuhrmann A, Choi YS, Hribar KC, Taylor-Weiner H, Chen S, Engler AJ. Wen JH, et al. Nat Mater. 2014 Oct;13(10):979-87. doi: 10.1038/nmat4051. Epub 2014 Aug 10. Nat Mater. 2014. PMID: 25108614 Free PMC article.
A novel mode of cell detachment from fibrillar fibronectin matrix under shear.
Engler AJ, Chan M, Boettiger D, Schwarzbauer JE. Engler AJ, et al. J Cell Sci. 2009 May 15;122(Pt 10):1647-53. doi: 10.1242/jcs.040824. Epub 2009 Apr 28. J Cell Sci. 2009. PMID: 19401337 Free PMC article.
Extracellular matrix elasticity directs stem cell differentiation.
Engler AJ, Sweeney HL, Discher DE, Schwarzbauer JE. Engler AJ, et al. J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):335. J Musculoskelet Neuronal Interact. 2007. PMID: 18094500 No abstract available.
Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating.
Engler AJ, Carag-Krieger C, Johnson CP, Raab M, Tang HY, Speicher DW, Sanger JW, Sanger JM, Discher DE. Engler AJ, et al. J Cell Sci. 2008 Nov 15;121(Pt 22):3794-802. doi: 10.1242/jcs.029678. Epub 2008 Oct 28. J Cell Sci. 2008. PMID: 18957515 Free PMC article.
Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery.
Rehfeldt F, Engler AJ, Eckhardt A, Ahmed F, Discher DE. Rehfeldt F, et al. Adv Drug Deliv Rev. 2007 Nov 10;59(13):1329-39. doi: 10.1016/j.addr.2007.08.007. Epub 2007 Aug 14. Adv Drug Deliv Rev. 2007. PMID: 17900747 Free PMC article. Review.
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments.
Engler AJ, Griffin MA, Sen S, Bönnemann CG, Sweeney HL, Discher DE. Engler AJ, et al. J Cell Biol. 2004 Sep 13;166(6):877-87. doi: 10.1083/jcb.200405004. J Cell Biol. 2004. PMID: 15364962 Free PMC article.
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