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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1988 1
1989 1
1990 1
1991 2
1992 1
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1997 5
1998 3
1999 5
2000 5
2001 3
2002 4
2003 3
2004 1
2005 3
2006 3
2007 2
2008 3
2009 2
2010 4
2011 3
2012 7
2013 4
2014 7
2015 7
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113 results

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Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer.
Alexander MS, O'Leary BR, Wilkes JG, Gibson AR, Wagner BA, Du J, Sarsour E, Hwang RF, Buettner GR, Cullen JJ. Alexander MS, et al. Radiat Res. 2019 Jan;191(1):43-51. doi: 10.1667/RR15189.1. Epub 2018 Oct 30. Radiat Res. 2019. PMID: 30376411 Free PMC article.
In vivo experiments using a murine model demonstrated an increased rate of ascorbate oxidation when combinations of P-AscH(-) with MnT4MPyP were given, thus acting as a radiosensitizer. ...Combination treatment utilizing P-AscH(-), manganoporphyrin and rad
In vivo experiments using a murine model demonstrated an increased rate of ascorbate oxidation when combinations of P-AscH(-) …
Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.
Du J, Cieslak JA 3rd, Welsh JL, Sibenaller ZA, Allen BG, Wagner BA, Kalen AL, Doskey CM, Strother RK, Button AM, Mott SL, Smith B, Tsai S, Mezhir J, Goswami PC, Spitz DR, Buettner GR, Cullen JJ. Du J, et al. Cancer Res. 2015 Aug 15;75(16):3314-26. doi: 10.1158/0008-5472.CAN-14-1707. Epub 2015 Jun 16. Cancer Res. 2015. PMID: 26081808 Free PMC article.
The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the oxidation of ascorbate. Because pancreatic cancer cells are sensitive to H2O2 generated by ascorbate, they would also be expected to become sensitized to ag
The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the oxidation of ascorbate. Be …
Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy.
Mehdi Z, Petronek MS, Stolwijk JM, Mapuskar KA, Kalen AL, Buettner GR, Cullen JJ, Spitz DR, Buatti JM, Allen BG. Mehdi Z, et al. Int J Mol Sci. 2021 Oct 8;22(19):10880. doi: 10.3390/ijms221910880. Int J Mol Sci. 2021. PMID: 34639220 Free PMC article. Review.
Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation sensitizer in cancer. ...Additionally, we present new data demonstrating the ability of pharmacological ascorbate to enh
Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation
Inhibition of platelet activation using vitamins.
Kobzar G. Kobzar G. Platelets. 2020;31(2):157-166. doi: 10.1080/09537104.2019.1652262. Epub 2019 Aug 19. Platelets. 2020. PMID: 31422726 Review.
Anti-platelet vitamins can act directly through inhibitory biochemical pathways in platelets or indirectly by preventing damage to the endothelium or low-density lipoprotein from oxidation. As a rule, each vitamin alone is a weak inhibitor of platelet aggregation. However, …
Anti-platelet vitamins can act directly through inhibitory biochemical pathways in platelets or indirectly by preventing damage to the endot …
Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer.
Moser JC, Rawal M, Wagner BA, Du J, Cullen JJ, Buettner GR. Moser JC, et al. Redox Biol. 2013 Nov 26;2:22-7. doi: 10.1016/j.redox.2013.11.005. eCollection 2013. Redox Biol. 2013. PMID: 24396727 Free PMC article.
Two cancer treatments where labile iron may contribute to their mechanism of action are pharmacological ascorbate and ionizing radiation (IR). Pharmacological ascorbate has been shown to have tumor-specific toxic effects due to the formation of …
Two cancer treatments where labile iron may contribute to their mechanism of action are pharmacological ascorbate and ionizing …
Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics.
Koo S, Lee MG, Sharma A, Li M, Zhang X, Pu K, Chi SG, Kim JS. Koo S, et al. Angew Chem Int Ed Engl. 2022 Apr 19;61(17):e202110832. doi: 10.1002/anie.202110832. Epub 2022 Mar 3. Angew Chem Int Ed Engl. 2022. PMID: 35142018
Due to the unique pro-oxidant role of ascorbate in tumor environments, AA-EtNBS effectively sensitized KM12C cancer cells prior to PS-mediated generation of superoxide radicals under near-infrared (NIR) illumination. ...Therefore, this study outlines a promising str …
Due to the unique pro-oxidant role of ascorbate in tumor environments, AA-EtNBS effectively sensitized KM12C cancer cells prio …
Pharmacological Ascorbate Promotes the Tumor Radiosensitization of Au@Pd Nanoparticles with Simultaneous Protection of Normal Tissues.
Liu Q, Shi Y, Chong Y, Ge C. Liu Q, et al. ACS Appl Bio Mater. 2021 Feb 15;4(2):1843-1851. doi: 10.1021/acsabm.0c01537. Epub 2021 Jan 27. ACS Appl Bio Mater. 2021. PMID: 35014530
By engineering the Au@Pd core-shell nanostructures and precisely regulating their shell thickness, the obtained Au@Pd nanomaterials exhibit excellent ascorbate oxidase-like activity. Along with the accelerating generation of H(2)O(2), pharmacological ascorbate
By engineering the Au@Pd core-shell nanostructures and precisely regulating their shell thickness, the obtained Au@Pd nanomaterials exhibit …
Manipulation of Redox Metabolism Using Pharmacologic Ascorbate Opens a Therapeutic Window for Radio-Sensitization by ATM Inhibitors in Colorectal Cancer.
Callaghan CM, Abukhiran IM, Masaadeh A, Van Rheeden RV, Kalen AL, Rodman SN 3rd, Petronek MS, Mapuskar KA, George BN, Coleman MC, Goswami PC, Allen BG, Spitz DR, Caster JM. Callaghan CM, et al. Int J Radiat Oncol Biol Phys. 2023 Mar 15;115(4):933-944. doi: 10.1016/j.ijrobp.2022.10.012. Epub 2022 Oct 11. Int J Radiat Oncol Biol Phys. 2023. PMID: 36228747 Free PMC article.
Pharmacologic ascorbate (P-AscH(-); intravenous administration achieving mM plasma concentrations) selectively enhances H(2)O(2)-induced oxidative stress and radiosensitization in tumors while acting as an antioxidant and mitigating radiation
Pharmacologic ascorbate (P-AscH(-); intravenous administration achieving mM plasma concentrations) selectively enhances
Hydrogen Peroxide Mediates Pharmacological Ascorbate Induced Radio-Sensitization of Pancreatic Cancer Cells by Enhancing G2-accumulation and Reducing Cyclin B1 Protein Levels.
O'Leary BR, Kalen AL, Pope AN, Goswami PC, Cullen JJ. O'Leary BR, et al. Radiat Res. 2023 Nov 1;200(5):444-455. doi: 10.1667/RADE-22-00182.1. Radiat Res. 2023. PMID: 37758045
Pharmacological ascorbate (P-AscH-, high dose, intravenous vitamin C) preferentially sensitizes human pancreas ductal adenocarcinoma (PDAC) cells to radiation-induced toxicity compared to non-tumorigenic epithelial cells. ...Results from the mitotic index and
Pharmacological ascorbate (P-AscH-, high dose, intravenous vitamin C) preferentially sensitizes human pancreas ductal adenocar
Anticarcinogenic actions of melatonin which involve antioxidative processes: comparison with other antioxidants.
Karbownik M, Lewinski A, Reiter RJ. Karbownik M, et al. Int J Biochem Cell Biol. 2001 Aug;33(8):735-53. doi: 10.1016/s1357-2725(01)00059-0. Int J Biochem Cell Biol. 2001. PMID: 11404179 Review.
The complex processes of carcinogenesis often involve oxidative stress. Numerous indicators of oxidative damage are enhanced as the result of the action of carcinogens. ...The indoleamine has been shown to protect macromolecules from oxidative mutilati …
The complex processes of carcinogenesis often involve oxidative stress. Numerous indicators of oxidative damage are enhance
113 results