Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer.
Radiat Res. 2019.
PMID: 30376411
Free PMC article.
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Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer.
Radiat Res. 2019 Jan;191(1):43-51. doi: 10.1667/RR15189.1. Epub 2018 Oct 30.
Radiat Res. 2019.
PMID: 30376411
Free PMC article.
In vivo experiments using a murine model demonstrated an increased rate of ascorbate oxidation when combinations of P-AscH(-) with MnT4MPyP were given, thus acting as a radiosensitizer. ...Combination treatment utilizing P-AscH(-), manganoporphyrin and rad …
In vivo experiments using a murine model demonstrated an increased rate of ascorbate oxidation when combinations of P-AscH(-) …
Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.
Cancer Res. 2015 Aug 15;75(16):3314-26. doi: 10.1158/0008-5472.CAN-14-1707. Epub 2015 Jun 16.
Cancer Res. 2015.
PMID: 26081808
Free PMC article.
The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the oxidation of ascorbate. Because pancreatic cancer cells are sensitive to H2O2 generated by ascorbate, they would also be expected to become sensitized to ag …
The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the oxidation of ascorbate. Be …
Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy.
Int J Mol Sci. 2021 Oct 8;22(19):10880. doi: 10.3390/ijms221910880.
Int J Mol Sci. 2021.
PMID: 34639220
Free PMC article.
Review.
Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation sensitizer in cancer. ...Additionally, we present new data demonstrating the ability of pharmacological ascorbate to enh …
Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation …
Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H(2)O(2).
Redox Biol. 2025 Mar;80:103505. doi: 10.1016/j.redox.2025.103505. Epub 2025 Jan 23.
Redox Biol. 2025.
PMID: 39884000
Free PMC article.
Pentaazamacrocyclic Mn (II)-containing (MnPAM) superoxide dismutase (SOD) mimetics and pharmacological ascorbate given IV to achieve [mM] plasma levels (pharmacological ascorbate: P-AscH ) have been shown to act individually as cancer cell radio- and c …
Pentaazamacrocyclic Mn (II)-containing (MnPAM) superoxide dismutase (SOD) mimetics and pharmacological ascorbate given IV to a …
Therapeutic combination of L-ascorbic acid, N-acetylcysteine, and dimethyl fumarate in Friedreich's ataxia: insights from in vitro models.
Redox Rep. 2025 Dec;30(1):2505303. doi: 10.1080/13510002.2025.2505303. Epub 2025 May 15.
Redox Rep. 2025.
PMID: 40375363
Free PMC article.
This study aimed to evaluate the therapeutic potential of antioxidants dimethyl fumarate (DMF), N-acetylcysteine (NAC), and L-ascorbic acid (LAA) in restoring mitochondrial redox homeostasis and frataxin levels in FRDA patient-derived fibroblasts and 2D sensory neurons. .. …
This study aimed to evaluate the therapeutic potential of antioxidants dimethyl fumarate (DMF), N-acetylcysteine (NAC), and L-ascorbic …
Inhibition of platelet activation using vitamins.
Platelets. 2020;31(2):157-166. doi: 10.1080/09537104.2019.1652262. Epub 2019 Aug 19.
Platelets. 2020.
PMID: 31422726
Review.
Anti-platelet vitamins can act directly through inhibitory biochemical pathways in platelets or indirectly by preventing damage to the endothelium or low-density lipoprotein from oxidation. As a rule, each vitamin alone is a weak inhibitor of platelet aggregation. However, …
Anti-platelet vitamins can act directly through inhibitory biochemical pathways in platelets or indirectly by preventing damage to the endot …
Leveraging Vitamin C to Augment Nanoenabled Photothermal Immunotherapy.
ACS Nano. 2025 Apr 8;19(13):12982-12995. doi: 10.1021/acsnano.4c17080. Epub 2025 Mar 26.
ACS Nano. 2025.
PMID: 40138545
This study introduces Vitamin C (VC), a widely available dietary nutrient, as an effective enhancer for PTI. High-dose VC induces oxidative imbalance in tumor cells, making them more susceptible to nanoenabled near-infrared-II photothermal therapy (NIR-II PTT) with …
This study introduces Vitamin C (VC), a widely available dietary nutrient, as an effective enhancer for PTI. High-dose VC induces …
Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics.
Angew Chem Int Ed Engl. 2022 Apr 19;61(17):e202110832. doi: 10.1002/anie.202110832. Epub 2022 Mar 3.
Angew Chem Int Ed Engl. 2022.
PMID: 35142018
Herein, we report a molecular strategy exploiting ascorbate chemistry to enhance the efficacy of PDT in cancer cells overexpressing glucose transporter 1 (GLUT1). ...Due to the unique pro-oxidant role of ascorbate in tumor environments, AA-EtNBS effect …
Herein, we report a molecular strategy exploiting ascorbate chemistry to enhance the efficacy of PDT in cancer cells overexpre …
Pharmacological Ascorbate Promotes the Tumor Radiosensitization of Au@Pd Nanoparticles with Simultaneous Protection of Normal Tissues.
ACS Appl Bio Mater. 2021 Feb 15;4(2):1843-1851. doi: 10.1021/acsabm.0c01537. Epub 2021 Jan 27.
ACS Appl Bio Mater. 2021.
PMID: 35014530
By engineering the Au@Pd core-shell nanostructures and precisely regulating their shell thickness, the obtained Au@Pd nanomaterials exhibit excellent ascorbate oxidase-like activity. Along with the accelerating generation of H(2)O(2), pharmacological ascorbate …
By engineering the Au@Pd core-shell nanostructures and precisely regulating their shell thickness, the obtained Au@Pd nanomaterials exhibit …
Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer.
Redox Biol. 2013 Nov 26;2:22-7. doi: 10.1016/j.redox.2013.11.005. eCollection 2013.
Redox Biol. 2013.
PMID: 24396727
Free PMC article.
Two cancer treatments where labile iron may contribute to their mechanism of action are pharmacological ascorbate and ionizing radiation (IR). Pharmacological ascorbate has been shown to have tumor-specific toxic effects due to the formation of …
Two cancer treatments where labile iron may contribute to their mechanism of action are pharmacological ascorbate and ionizing …
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