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Type 1 interferon gene transfer enhances host defense against pulmonary Streptococcus pneumoniae infection via activating innate leukocytes.
Damjanovic D, Khera A, Medina MF, Ennis J, Turner JD, Gauldie J, Xing Z. Damjanovic D, et al. Mol Ther Methods Clin Dev. 2014 Mar 19;1:5. doi: 10.1038/mtm.2014.5. eCollection 2014. Mol Ther Methods Clin Dev. 2014. PMID: 26015944 Free PMC article.
Single-dose intranasal treatment with DEF201 (adenovirus vectored consensus interferon) prevents lethal disease due to Rift Valley fever virus challenge.
Gowen BB, Ennis J, Bailey KW, Vest Z, Scharton D, Sefing EJ, Turner JD. Gowen BB, et al. Viruses. 2014 Mar 24;6(3):1410-23. doi: 10.3390/v6031410. Viruses. 2014. PMID: 24662673 Free PMC article.
Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses.
Smee DF, Wong MH, Hurst BL, Ennis J, Turner JD. Smee DF, et al. PLoS One. 2013 Jul 9;8(7):e68685. doi: 10.1371/journal.pone.0068685. Print 2013. PLoS One. 2013. PMID: 23874722 Free PMC article.
Extended protection against phlebovirus infection conferred by recombinant adenovirus expressing consensus interferon (DEF201).
Gowen BB, Ennis J, Sefing EJ, Wong MH, Jung KH, Turner JD. Gowen BB, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4168-74. doi: 10.1128/AAC.00376-12. Epub 2012 May 21. Antimicrob Agents Chemother. 2012. PMID: 22615273 Free PMC article.
Use of recombinant adenovirus vectored consensus IFN-α to avert severe arenavirus infection.
Gowen BB, Ennis J, Russell A, Sefing EJ, Wong MH, Turner J. Gowen BB, et al. PLoS One. 2011;6(10):e26072. doi: 10.1371/journal.pone.0026072. Epub 2011 Oct 24. PLoS One. 2011. PMID: 22039436 Free PMC article.
Therapy and long-term prophylaxis of vaccinia virus respiratory infections in mice with an adenovirus-vectored interferon alpha (mDEF201).
Smee DF, Wong MH, Russell A, Ennis J, Turner JD. Smee DF, et al. PLoS One. 2011;6(10):e26330. doi: 10.1371/journal.pone.0026330. Epub 2011 Oct 13. PLoS One. 2011. PMID: 22022603 Free PMC article.
Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model.
Kumaki Y, Ennis J, Rahbar R, Turner JD, Wandersee MK, Smith AJ, Bailey KW, Vest ZG, Madsen JR, Li JK, Barnard DL. Kumaki Y, et al. Antiviral Res. 2011 Jan;89(1):75-82. doi: 10.1016/j.antiviral.2010.11.007. Epub 2010 Nov 18. Antiviral Res. 2011. PMID: 21093489 Free PMC article.
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