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Translational control of localized mRNAs: restricting protein synthesis in space and time.
Besse F, Ephrussi A. Besse F, et al. Nat Rev Mol Cell Biol. 2008 Dec;9(12):971-80. doi: 10.1038/nrm2548. Nat Rev Mol Cell Biol. 2008. PMID: 19023284 Review.
As highlighted by recent genome-wide analyses in diverse organisms and cell types, subcellular targeting of mRNAs has emerged as a major mechanism for cells to establish functionally distinct compartments and structures. ...Such a precise translation pattern is cont …
As highlighted by recent genome-wide analyses in diverse organisms and cell types, subcellular targeting of mRNAs has emerged as a ma …
Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization.
Erdélyi M, Michon AM, Guichet A, Glotzer JB, Ephrussi A. Erdélyi M, et al. Nature. 1995 Oct 12;377(6549):524-7. doi: 10.1038/377524a0. Nature. 1995. PMID: 7566149
In a screen for mutants defective in germ cell formation, we isolated nine alleles of the tropomyosin II gene. Here we show that mutations in tropomyosin II (TmII) virtually abolish oskar RNA localization to the posterior pole, suggesting an involvement of the actin networ …
In a screen for mutants defective in germ cell formation, we isolated nine alleles of the tropomyosin II gene. Here we show that muta …
Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly.
Markussen FH, Michon AM, Breitwieser W, Ephrussi A. Markussen FH, et al. Development. 1995 Nov;121(11):3723-32. Development. 1995. PMID: 8582284
As a first step towards understanding how oskar activity is restricted to the posterior pole, we analyzed oskar translation in wild type and mutants. ...Finally, we show that when oskar RNA is localized, accumulation of Oskar protein requires the functions of vasa and tudo …
As a first step towards understanding how oskar activity is restricted to the posterior pole, we analyzed oskar translation in wild t …
Oskar protein interaction with Vasa represents an essential step in polar granule assembly.
Breitwieser W, Markussen FH, Horstmann H, Ephrussi A. Breitwieser W, et al. Genes Dev. 1996 Sep 1;10(17):2179-88. doi: 10.1101/gad.10.17.2179. Genes Dev. 1996. PMID: 8804312
We have explored interactions between these gene products at the molecular level and find that Oskar interacts directly with Vasa and Staufen, in a yeast two-hybrid assay. ...Finally, we show that in the pole plasm, Oskar protein, like Vasa and Tudor, is a component …
We have explored interactions between these gene products at the molecular level and find that Oskar interacts directly with Vasa and Staufe …
The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors.
Guichet A, Copeland JW, Erdélyi M, Hlousek D, Závorszky P, Ho J, Brown S, Percival-Smith A, Krause HM, Ephrussi A. Guichet A, et al. Nature. 1997 Feb 6;385(6616):548-52. doi: 10.1038/385548a0. Nature. 1997. PMID: 9020363
The Drosophila gene fushi tarazu (ftz), which encodes a homeodomain protein (Ftz), is required zygotically for the formation of alternate segments in the developing embryo. ...The two proteins interact specifically and directly, both in vitro and in vivo, through a
The Drosophila gene fushi tarazu (ftz), which encodes a homeodomain protein (Ftz), is required zygotically for the formation of alter …
Cytoplasmic flows localize injected oskar RNA in Drosophila oocytes.
Glotzer JB, Saffrich R, Glotzer M, Ephrussi A. Glotzer JB, et al. Curr Biol. 1997 May 1;7(5):326-37. doi: 10.1016/s0960-9822(06)00156-4. Curr Biol. 1997. PMID: 9115398
In oocytes at stages 10 and 11, the long-range movement of injected osk RNA is promoted by a vigorous, microtubule-dependent cytoplasmic flow, or ooplasmic streaming. Treatment with colchicine, a microtubule-destabilizing drug, inhibits ooplasmic streaming and preve …
In oocytes at stages 10 and 11, the long-range movement of injected osk RNA is promoted by a vigorous, microtubule-dependent cytoplas …
Oocyte polarity depends on regulation of gurken by Vasa.
Tomancak P, Guichet A, Zavorszky P, Ephrussi A. Tomancak P, et al. Development. 1998 May;125(9):1723-32. Development. 1998. PMID: 9521910
Vasa, a DEAD box mRNA helicase similar to eIF4A, is involved in pole plasm assembly in the Drosophila oocyte and appears to regulate translation of oskar and nanos mRNAs. However, several vasa alleles exhibit a wide range of early oogenesis phenotypes. Here we repor …
Vasa, a DEAD box mRNA helicase similar to eIF4A, is involved in pole plasm assembly in the Drosophila oocyte and appears to regulate …
Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA.
Gunkel N, Yano T, Markussen FH, Olsen LC, Ephrussi A. Gunkel N, et al. Genes Dev. 1998 Jun 1;12(11):1652-64. doi: 10.1101/gad.12.11.1652. Genes Dev. 1998. PMID: 9620852 Free PMC article.
The precise restriction of proteins to specific domains within a cell plays an important role in early development and differentiation. ...A central issue is how localized mRNAs are derepressed. In this study we demonstrate that, when oskar mRNA reaches the posterio …
The precise restriction of proteins to specific domains within a cell plays an important role in early development and differentiatio …
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries.
Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. Castagnetti S, et al. Development. 2000 Mar;127(5):1063-8. Development. 2000. PMID: 10662645
We have established a cell-free translation system derived from Drosophila ovaries, which faithfully reproduces critical features of mRNA translation in vivo, namely cap structure and poly(A) tail dependence. ...Addition of recombinant Bruno to this extract establis …
We have established a cell-free translation system derived from Drosophila ovaries, which faithfully reproduces critical features of …
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