Epigenetics and environment: a complex relationship.
J Appl Physiol (1985). 2010.
PMID: 20378707
Review.
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Genetics, epigenetics and transgenerational transmission of obesity in children.
Front Endocrinol (Lausanne). 2022 Nov 14;13:1006008. doi: 10.3389/fendo.2022.1006008. eCollection 2022.
Front Endocrinol (Lausanne). 2022.
PMID: 36452324
Free PMC article.
Review.
Even the pre-conception direct exposure of either father or mother gametes to environmental factors can reprogram the epigenetic architecture of cells. Such phenomena lie behind the transfer of the obesity susceptibility to future generations through a mechanism of epig …
Even the pre-conception direct exposure of either father or mother gametes to environmental factors can reprogram the epigenetic arch …
Asthma risk factors.
Int Forum Allergy Rhinol. 2015 Sep;5 Suppl 1(Suppl 1):S11-6. doi: 10.1002/alr.21557.
Int Forum Allergy Rhinol. 2015.
PMID: 26335830
Free PMC article.
Review.
CONCLUSION: Asthma represents a dysfunctional interaction with our genes and the environment to which they are exposed, especially in fetal and early infant life. The increasing prevalence of asthma in all age groups indicate that our living environment and immunity …
CONCLUSION: Asthma represents a dysfunctional interaction with our genes and the environment to which they are exposed, especially in …
Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics.
Int J Mol Sci. 2024 Jan 19;25(2):1228. doi: 10.3390/ijms25021228.
Int J Mol Sci. 2024.
PMID: 38279228
Free PMC article.
Review.
It appears that the modulation of the microbiota by various nutrients may lead to epigenetic regulation. The correlations between microbiota and epigenetics are potentially interdependent. Therefore, the primary objective of this review is to identify the complex …
It appears that the modulation of the microbiota by various nutrients may lead to epigenetic regulation. The correlations between mic …
Epigenetic regulation by gut microbiota.
Gut Microbes. 2022 Jan-Dec;14(1):2022407. doi: 10.1080/19490976.2021.2022407.
Gut Microbes. 2022.
PMID: 35000562
Free PMC article.
Review.
Microbiota-sensitive epigenetic changes include modifications to the DNA or histones, as well as regulation of non-coding RNAs. While microbiota-sensitive epigenetic mechanisms have been described in both local intestinal cells and as well in peripheral tissues, fur …
Microbiota-sensitive epigenetic changes include modifications to the DNA or histones, as well as regulation of non-coding RNAs. While …
Epigenetics and environment: a complex relationship.
J Appl Physiol (1985). 2010 Jul;109(1):243-51. doi: 10.1152/japplphysiol.00068.2010. Epub 2010 Apr 8.
J Appl Physiol (1985). 2010.
PMID: 20378707
Free article.
Review.
The epigenomes of higher organisms constantly change over time. Many of these epigenetic changes are necessary to direct normal cellular development and differentiation in the developing organism. However, developmental abnormalities may occur in response to inappropriate …
The epigenomes of higher organisms constantly change over time. Many of these epigenetic changes are necessary to direct normal cellu …
Glutathione--linking cell proliferation to oxidative stress.
Free Radic Biol Med. 2015 Dec;89:1154-64. doi: 10.1016/j.freeradbiomed.2015.09.023. Epub 2015 Nov 3.
Free Radic Biol Med. 2015.
PMID: 26546102
Free article.
Review.
Moreover, measurements of in vivo glutathione redox potentials reveal that the cellular environment is much more reducing than predicted from GSH/GSSG ratios measured in tissue extracts. ...FUTURE DIRECTIONS: The nuclear GSH pool provides an appropriate redox environmen …
Moreover, measurements of in vivo glutathione redox potentials reveal that the cellular environment is much more reducing than predic …
Epigenetic changes by per- and polyfluoroalkyl substances (PFAS).
Environ Pollut. 2021 Jun 15;279:116929. doi: 10.1016/j.envpol.2021.116929. Epub 2021 Mar 15.
Environ Pollut. 2021.
PMID: 33751946
Review.
Additional studies are necessary to define specific linkages among epigenetic mechanisms and related biomarkers or phenotypical changes. In addition, future research is also needed for understudied PFAS and complex mixtures. Studies of epigenetic effects elic …
Additional studies are necessary to define specific linkages among epigenetic mechanisms and related biomarkers or phenotypical chang …
What is new in the exposome?
Environ Int. 2020 Oct;143:105887. doi: 10.1016/j.envint.2020.105887. Epub 2020 Jun 30.
Environ Int. 2020.
PMID: 32619912
Free article.
Review.
Biomarkers and omic technologies may allow better causal attribution, for example using instrumental variables in triangulation, as we discuss here. Even more complex is the understanding of how social relationships (in particular socio-economic differences) influen …
Biomarkers and omic technologies may allow better causal attribution, for example using instrumental variables in triangulation, as we discu …
Genetics and Obesity.
2023 Jul 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–.
2023 Jul 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–.
PMID: 34424641
Free Books & Documents.
Obesity as a disease itself is multifactorial and occurs due to complex interactions occurring between genetics and the environment. The Human Genome project was carried out between the years 1990 to 2003 to map out the human genome. ...However, the modern definitio …
Obesity as a disease itself is multifactorial and occurs due to complex interactions occurring between genetics and the environmen …
Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics.
Biomed Pharmacother. 2022 Sep;153:113290. doi: 10.1016/j.biopha.2022.113290. Epub 2022 Jun 17.
Biomed Pharmacother. 2022.
PMID: 35724509
Free article.
Review.
In addition, microbial metabolites can trigger inflammatory immune responses and microbiota dysbiosis by directly binding to G-protein-coupled receptors (GPCRs). Hence, diet-gut microbiota-epigenetics may play a role in metabolic diseases. However, their complex …
In addition, microbial metabolites can trigger inflammatory immune responses and microbiota dysbiosis by directly binding to G-protein-coupl …
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