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Page 1
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Araj SK, et al. Int J Mol Sci. 2025 Mar 17;26(6):2691. doi: 10.3390/ijms26062691. Int J Mol Sci. 2025. PMID: 40141333 Free PMC article. Review.
Moreover, despite the considerable volume of research on the biological and pharmacodynamic characteristics of Epitalon, the quantity of physico-chemical and structural investigations of this peptide remains quite limited. This review aims to conclude the most important fi …
Moreover, despite the considerable volume of research on the biological and pharmacodynamic characteristics of Epitalon, the quantity …
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.
Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, Song CY, Wang ZB, Schatten H, Sun QY, Guo XP. Yue X, et al. Aging (Albany NY). 2022 Apr 12;14(7):3191-3202. doi: 10.18632/aging.204007. Epub 2022 Apr 12. Aging (Albany NY). 2022. PMID: 35413689 Free PMC article.
The current study aims to test the protective effects of Epitalon on the quality of post-ovulatory aging oocytes. Epitalon at 0.1mM was added to the culture medium, and the quality of oocytes was evaluated at 6h, 12h, and 24h of culture. ...Our results suggest that …
The current study aims to test the protective effects of Epitalon on the quality of post-ovulatory aging oocytes. Epitalon at …
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Al-Dulaimi S, Thomas R, Matta S, Roberts T. Al-Dulaimi S, et al. Biogerontology. 2025 Sep 4;26(5):178. doi: 10.1007/s10522-025-10315-x. Biogerontology. 2025. PMID: 40908429 Free PMC article.
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. ...Only a minor increase in ALT activity was observed in Normal cells, thereby showing that it was specific to cancer cells. Our data suggests that epitalon can ext …
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. ...Only a minor increase in ALT …
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Gatta M, Dovizio M, Milillo C, Ruggieri AG, Sallese M, Antonucci I, Trofimov A, Khavinson V, Trofimova S, Bruno A, Ballerini P. Gatta M, et al. Stem Cell Rev Rep. 2025 Aug;21(6):1822-1834. doi: 10.1007/s12015-025-10911-x. Epub 2025 Jun 10. Stem Cell Rev Rep. 2025. PMID: 40493162 Free PMC article.
These findings support using the antioxidant agent Epitalon as a promising therapeutic strategy for DR to improve retinal wound healing compromised by hyperglycemia. More mechanistic investigations are needed to confirm Epitalon's benefits and safety. Developing oph …
These findings support using the antioxidant agent Epitalon as a promising therapeutic strategy for DR to improve retinal wound heali …
Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.
Ullah S, Haider Z, Perera CD, Lee SH, Idrees M, Park S, Kong IK. Ullah S, et al. Life Sci. 2025 Feb 1;362:123381. doi: 10.1016/j.lfs.2025.123381. Epub 2025 Jan 7. Life Sci. 2025. PMID: 39788414
Moreover, we performed qPCR, reactive oxygen species, and JC-1 (deltapsim) assays to evaluate the effect of Epitalon on the health of in vitro mature oocytes, cumulus cells, and post-thawed blastocysts, and the result showed that Epitalon highly enhances the quality …
Moreover, we performed qPCR, reactive oxygen species, and JC-1 (deltapsim) assays to evaluate the effect of Epitalon on the health of …
Peptides and Ageing.
Khavinson VKh. Khavinson VKh. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. Neuro Endocrinol Lett. 2002. PMID: 12374906 Review.
Epitalon reproduces the effects of Epithalamin including those related to its geroprotector activity. In particular, Epitalon increases the lifespan of mice and fruit flies and restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys …
Epitalon reproduces the effects of Epithalamin including those related to its geroprotector activity. In particular, Epitalon …
Epitalon influences pineal secretion in stress-exposed rats in the daytime.
Sibarov DA, Kovalenko RI, Malinin VV, Khavinson VKh. Sibarov DA, et al. Neuro Endocrinol Lett. 2002 Oct-Dec;23(5-6):452-4. Neuro Endocrinol Lett. 2002. PMID: 12500171
The dilation of capillaries and pericapillary space induced by an osmotic stress was partially reduced by the intranasal infusions of Epitalon. CONCLUSIONS: Tetrapeptide Epitalon is synthesised on the basis of the amino acid composition of pineal peptide extract Epi …
The dilation of capillaries and pericapillary space induced by an osmotic stress was partially reduced by the intranasal infusions of Epi …
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. Khavinson V, et al. Molecules. 2020 Jan 30;25(3):609. doi: 10.3390/molecules25030609. Molecules. 2020. PMID: 32019204 Free PMC article.
It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. AEDG peptide increases longevity in animals and decreases experimental cancerogenesis. ...
It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. AED …
Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.
Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Kossoy G, et al. Int J Mol Med. 2003 Oct;12(4):473-7. Int J Mol Med. 2003. PMID: 12964022
Rats in group 3 were treated with Epitalon after termination of the carcinogen injections. Rats in group 4 were treated with Epitalon only during the period of DMH exposure (for the first 5 weeks of the experiment). ...Thus, the strongest inhibitory effect of Epi …
Rats in group 3 were treated with Epitalon after termination of the carcinogen injections. Rats in group 4 were treated with Epita …
130 results