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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184 Free article.
Regulation of gene expression by oxygen levels in mammalian cells.
Pugh CW, Chang GW, Cockman M, Epstein AC, Gleadle JM, Maxwell PH, Nicholls LG, O'Rourke JF, Ratcliffe PJ, Raybould EC, Tian YM, Wiesener MS, Wood M, Wykoff CC, Yeates KM. Pugh CW, et al. Among authors: epstein ac. Adv Nephrol Necker Hosp. 1999;29:191-206. Adv Nephrol Necker Hosp. 1999. PMID: 10561745 Review. No abstract available.
Should cancer patients be dialyzed?
Epstein AC. Epstein AC. Semin Nephrol. 1993 May;13(3):315-23. Semin Nephrol. 1993. PMID: 8321931 Review. No abstract available.