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Liver-targeted drug delivery using HepDirect prodrugs.
Erion MD, van Poelje PD, Mackenna DA, Colby TJ, Montag AC, Fujitaki JM, Linemeyer DL, Bullough DA. Erion MD, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):554-60. doi: 10.1124/jpet.104.075903. Epub 2004 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 15340017
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.
Dang Q, Kasibhatla SR, Reddy KR, Jiang T, Reddy MR, Potter SC, Fujitaki JM, van Poelje PD, Huang J, Lipscomb WN, Erion MD. Dang Q, et al. Among authors: erion md. J Am Chem Soc. 2007 Dec 19;129(50):15491-502. doi: 10.1021/ja074871l. Epub 2007 Nov 28. J Am Chem Soc. 2007. PMID: 18041834
106 results