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95 results
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Isolation of a family of organic anion transporters from human liver and kidney.
Sun W, Wu RR, van Poelje PD, Erion MD. Sun W, et al. Among authors: erion md. Biochem Biophys Res Commun. 2001 May 4;283(2):417-22. doi: 10.1006/bbrc.2001.4774. Biochem Biophys Res Commun. 2001. PMID: 11327718
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.
Reddy KR, Matelich MC, Ugarkar BG, Gómez-Galeno JE, DaRe J, Ollis K, Sun Z, Craigo W, Colby TJ, Fujitaki JM, Boyer SH, van Poelje PD, Erion MD. Reddy KR, et al. Among authors: erion md. J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173234
Liver-targeted drug delivery using HepDirect prodrugs.
Erion MD, van Poelje PD, Mackenna DA, Colby TJ, Montag AC, Fujitaki JM, Linemeyer DL, Bullough DA. Erion MD, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):554-60. doi: 10.1124/jpet.104.075903. Epub 2004 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 15340017
Calculation of relative binding free energy differences for fructose 1,6-bisphosphatase inhibitors using the thermodynamic cycle perturbation approach.
Reddy MR, Erion MD. Reddy MR, et al. Among authors: erion md. J Am Chem Soc. 2001 Jul 4;123(26):6246-52. doi: 10.1021/ja0103288. J Am Chem Soc. 2001. PMID: 11427047
Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates.
Dang Q, Brown BS, van Poelje PD, Colby TJ, Erion MD. Dang Q, et al. Among authors: erion md. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1505-10. doi: 10.1016/s0960-894x(99)00239-5. Bioorg Med Chem Lett. 1999. PMID: 10386925
Liver targeting of hepatitis-B antiviral lamivudine using the HepDirect prodrug technology.
Reddy KR, Colby TJ, Fujitaki JM, van Poelje PD, Erion MD. Reddy KR, et al. Among authors: erion md. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):375-81. doi: 10.1081/ncn-200059781. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247954
AMP deaminase inhibitors. 5. Design, synthesis, and SAR of a highly potent inhibitor series.
Kasibhatla SR, Bookser BC, Xiao W, Erion MD. Kasibhatla SR, et al. Among authors: erion md. J Med Chem. 2001 Feb 15;44(4):613-8. doi: 10.1021/jm000355t. J Med Chem. 2001. PMID: 11170651
Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist.
Fujitaki JM, Cable EE, Ito BR, Zhang BH, Hou J, Yang C, Bullough DA, Ferrero JL, van Poelje PD, Linemeyer DL, Erion MD. Fujitaki JM, et al. Among authors: erion md. Drug Metab Dispos. 2008 Nov;36(11):2393-403. doi: 10.1124/dmd.108.021642. Epub 2008 Aug 14. Drug Metab Dispos. 2008. PMID: 18703645
Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys.
Lin CC, Yeh LT, Vitarella D, Hong Z, Erion MD. Lin CC, et al. Among authors: erion md. Antivir Chem Chemother. 2004 Nov;15(6):307-17. doi: 10.1177/095632020401500603. Antivir Chem Chemother. 2004. PMID: 15646644
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.
Dang Q, Kasibhatla SR, Reddy KR, Jiang T, Reddy MR, Potter SC, Fujitaki JM, van Poelje PD, Huang J, Lipscomb WN, Erion MD. Dang Q, et al. Among authors: erion md. J Am Chem Soc. 2007 Dec 19;129(50):15491-502. doi: 10.1021/ja074871l. Epub 2007 Nov 28. J Am Chem Soc. 2007. PMID: 18041834
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