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Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches.
Auer T, Schreppel P, Erker T, Schwarzer C. Auer T, et al. Among authors: erker t. Pharmacol Ther. 2020 Jan;205:107422. doi: 10.1016/j.pharmthera.2019.107422. Epub 2019 Oct 15. Pharmacol Ther. 2020. PMID: 31626872 Review.
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Auer T, Schreppel P, Erker T, Schwarzer C. Auer T, et al. Among authors: erker t. Neuropharmacology. 2020 Jan 1;162:107754. doi: 10.1016/j.neuropharm.2019.107754. Epub 2019 Aug 30. Neuropharmacology. 2020. PMID: 31476353 Free article.
A Novel Na+-K+-Cl- Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke.
Huang H, Bhuiyan MIH, Jiang T, Song S, Shankar S, Taheri T, Li E, Schreppel P, Hintersteininger M, Yang SS, Lin SH, Molyneaux BJ, Zhang Z, Erker T, Sun D. Huang H, et al. Among authors: erker t. Stroke. 2019 Apr;50(4):1021-1025. doi: 10.1161/STROKEAHA.118.024287. Stroke. 2019. PMID: 30862257 Free PMC article.
The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines.
Kucinska M, Mieszczak H, Piotrowska-Kempisty H, Kaczmarek M, Granig W, Murias M, Erker T. Kucinska M, et al. Among authors: erker t. Invest New Drugs. 2019 Oct;37(5):849-864. doi: 10.1007/s10637-018-0704-8. Epub 2018 Nov 29. Invest New Drugs. 2019. PMID: 30498945 Free PMC article.
Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain.
Römermann K, Fedrowitz M, Hampel P, Kaczmarek E, Töllner K, Erker T, Sweet DH, Löscher W. Römermann K, et al. Among authors: erker t. Neuropharmacology. 2017 May 1;117:182-194. doi: 10.1016/j.neuropharm.2017.02.006. Epub 2017 Feb 10. Neuropharmacology. 2017. PMID: 28192112
Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells.
Kucinska M, Piotrowska-Kempisty H, Lisiak N, Kaczmarek M, Dams-Kozlowska H, Granig WH, Höferl M, Jäger W, Zehl M, Murias M, Erker T. Kucinska M, et al. Among authors: erker t. Toxicol In Vitro. 2016 Dec;37:148-161. doi: 10.1016/j.tiv.2016.09.017. Epub 2016 Sep 19. Toxicol In Vitro. 2016. PMID: 27660182
A Novel Genistein Prodrug: Design, Synthesis and Bioactivity on Mouse RAW264.7 Macrophages.
Kloesch B, Loebsch S, Breitenbach J, Goldhahn K, Handler N, Schreppel P, Erker T. Kloesch B, et al. Among authors: erker t. Nat Prod Commun. 2016 Oct;11(10):1437-1440. Nat Prod Commun. 2016. PMID: 30549594
The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A.
Lykke K, Töllner K, Feit PW, Erker T, MacAulay N, Löscher W. Lykke K, et al. Among authors: erker t. Epilepsy Behav. 2016 Jun;59:42-9. doi: 10.1016/j.yebeh.2016.03.021. Epub 2016 Apr 15. Epilepsy Behav. 2016. PMID: 27088517
The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.
Erker T, Brandt C, Töllner K, Schreppel P, Twele F, Schidlitzki A, Löscher W. Erker T, et al. Epilepsia. 2016 May;57(5):698-705. doi: 10.1111/epi.13346. Epub 2016 Feb 27. Epilepsia. 2016. PMID: 26921222 Free article.
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