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Identification of substrates for cyclin dependent kinases.
Errico A, Deshmukh K, Tanaka Y, Pozniakovsky A, Hunt T. Errico A, et al. Adv Enzyme Regul. 2010;50(1):375-99. doi: 10.1016/j.advenzreg.2009.12.001. Epub 2010 Jan 4. Adv Enzyme Regul. 2010. PMID: 20045433 Review. No abstract available.
Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.
Errico A, Costanzo V, Hunt T. Errico A, et al. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14929-34. doi: 10.1073/pnas.0706347104. Epub 2007 Sep 10. Proc Natl Acad Sci U S A. 2007. PMID: 17846426 Free PMC article.
Tipin and its interacting partner Tim1 (Timeless) form a complex at replication forks that plays an important role in the DNA damage checkpoint response. Here we identify Xenopus laevis Tipin as a substrate for cyclin E/cyclin-dependent kinases 2 that is phosphoryla …
Tipin and its interacting partner Tim1 (Timeless) form a complex at replication forks that plays an important role in the DNA damage …
Plx1 is required for chromosomal DNA replication under stressful conditions.
Trenz K, Errico A, Costanzo V. Trenz K, et al. Among authors: errico a. EMBO J. 2008 Mar 19;27(6):876-85. doi: 10.1038/emboj.2008.29. Epub 2008 Feb 28. EMBO J. 2008. PMID: 18309293 Free PMC article.
Mechanisms of replication fork protection: a safeguard for genome stability.
Errico A, Costanzo V. Errico A, et al. Crit Rev Biochem Mol Biol. 2012 May-Jun;47(3):222-35. doi: 10.3109/10409238.2012.655374. Epub 2012 Feb 11. Crit Rev Biochem Mol Biol. 2012. PMID: 22324461 Review.
Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.
Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V. Errico A, et al. EMBO J. 2009 Dec 2;28(23):3681-92. doi: 10.1038/emboj.2009.304. Epub 2009 Nov 5. EMBO J. 2009. PMID: 19893489 Free PMC article.
We identified And1, a Polalpha chromatin-loading factor, as new Tipin-binding partner. We found that both Tipin and And1 promote stable binding of Polalpha to chromatin and that this is required for DNA replication under unchallenged conditions. ...These data indicate that …
We identified And1, a Polalpha chromatin-loading factor, as new Tipin-binding partner. We found that both Tipin and And1 promote stab …
Mta2 promotes Tipin-dependent maintenance of replication fork integrity.
Errico A, Aze A, Costanzo V. Errico A, et al. Cell Cycle. 2014;13(13):2120-8. doi: 10.4161/cc.29157. Epub 2014 May 15. Cell Cycle. 2014. PMID: 24830473 Free PMC article.
We identified Mta2, a subunit of the NuRD chromatin remodeler complex, as a novel Tipin binding partner and mediator of its function. ...Using a novel assay we developed to monitor replication of specific genomic loci in Xenopus laevis egg extract we demonstr …
We identified Mta2, a subunit of the NuRD chromatin remodeler complex, as a novel Tipin binding partner and mediator of its fu …
GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication.
Balestrini A, Cosentino C, Errico A, Garner E, Costanzo V. Balestrini A, et al. Among authors: errico a. Nat Cell Biol. 2010 May;12(5):484-91. doi: 10.1038/ncb2050. Epub 2010 Apr 11. Nat Cell Biol. 2010. PMID: 20383140 Free PMC article.
Here, we report the identification of GEMC1 (geminin coiled-coil containing protein 1), a novel vertebrate protein required for chromosomal DNA replication. ...
Here, we report the identification of GEMC1 (geminin coiled-coil containing protein 1), a novel vertebrate protein required for chrom …
Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns.
Errico A, Costanzo V. Errico A, et al. EMBO Rep. 2010 Apr;11(4):270-8. doi: 10.1038/embor.2010.27. Epub 2010 Feb 26. EMBO Rep. 2010. PMID: 20203697 Free PMC article. Review.
The crystal structure of human cyclin B.
Petri ET, Errico A, Escobedo L, Hunt T, Basavappa R. Petri ET, et al. Among authors: errico a. Cell Cycle. 2007 Jun 1;6(11):1342-9. doi: 10.4161/cc.6.11.4297. Epub 2007 Jun 14. Cell Cycle. 2007. PMID: 17495533
Cyclin B is the key regulatory protein controlling mitosis in all eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a complex which initiates the mitotic program through phosphorylation of select proteins. ...Here we report the crystal structure of human cy …
Cyclin B is the key regulatory protein controlling mitosis in all eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a
Targeted therapies: Hippo effector YAP1 inhibition-towards a new therapeutic option to overcome drug resistance.
Errico A. Errico A. Nat Rev Clin Oncol. 2015 Apr;12(4):190. doi: 10.1038/nrclinonc.2015.31. Epub 2015 Feb 24. Nat Rev Clin Oncol. 2015. PMID: 25707626 No abstract available.
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