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Preventing Brain Injury in the Preterm Infant-Current Controversies and Potential Therapies.
Yates N, Gunn AJ, Bennet L, Dhillon SK, Davidson JO. Yates N, et al. Int J Mol Sci. 2021 Feb 7;22(4):1671. doi: 10.3390/ijms22041671. Int J Mol Sci. 2021. PMID: 33562339 Free PMC article. Review.
Recombinant erythropoietin has shown neuroprotective potential in preclinical studies but two large randomized trials, in extremely preterm infants, of treatment started within 24 or 48 h of birth showed no effect on the risk of severe neurodevelopm …
Recombinant erythropoietin has shown neuroprotective potential in preclinical studies but two large randomized trials, in extremel …
Erythropoietin improves neurodevelopmental outcome of extremely preterm infants.
Neubauer AP, Voss W, Wachtendorf M, Jungmann T. Neubauer AP, et al. Ann Neurol. 2010 May;67(5):657-66. doi: 10.1002/ana.21977. Ann Neurol. 2010. PMID: 20437563 Clinical Trial.
No previous studies have investigated the neurodevelopmental outcome of extremely low birth weight (ELBW) infants treated with recombinant human erythropoietin (rEpo) and evaluated it at school age. ...The neurodevelopmental and school …
No previous studies have investigated the neurodevelopmental outcome of extremely low birth weight (ELBW) infants …
Dexamethasone, Prednisolone, and Methylprednisolone Use and 2-Year Neurodevelopmental Outcomes in Extremely Preterm Infants.
Puia-Dumitrescu M, Wood TR, Comstock BA, Law JB, German K, Perez KM, Gogcu S, Mayock DE, Heagerty PJ, Juul SE; Preterm Erythropoietin Neuroprotection (PENUT) Trial Consortium. Puia-Dumitrescu M, et al. JAMA Netw Open. 2022 Mar 1;5(3):e221947. doi: 10.1001/jamanetworkopen.2022.1947. JAMA Netw Open. 2022. PMID: 35275165 Free PMC article. Clinical Trial.
IMPORTANCE: Practice variability exists in the use of corticosteroids to treat or prevent bronchopulmonary dysplasia in extremely preterm infants, but there is limited information on longer-term impacts. OBJECTIVE: To describe the use of corticosteroids in …
IMPORTANCE: Practice variability exists in the use of corticosteroids to treat or prevent bronchopulmonary dysplasia in extremely …
Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis.
Fischer HS, Reibel NJ, Bührer C, Dame C. Fischer HS, et al. Pediatrics. 2017 May;139(5):e20164317. doi: 10.1542/peds.2016-4317. Epub 2017 Apr 7. Pediatrics. 2017. PMID: 28557760 Review.
OBJECTIVE: To investigate whether prophylactic rhEPO administration in very preterm infants improves neurodevelopmental outcomes in a meta-analysis of randomized controlled trials (RCTs). ...There was no statistically significant effect on any s …
OBJECTIVE: To investigate whether prophylactic rhEPO administration in very preterm infants improves neurodevelopmen …
Erythropoietin concentrations and neurodevelopmental outcome in preterm infants.
Bierer R, Peceny MC, Hartenberger CH, Ohls RK. Bierer R, et al. Pediatrics. 2006 Sep;118(3):e635-40. doi: 10.1542/peds.2005-3186. Epub 2006 Aug 14. Pediatrics. 2006. PMID: 16908620 Clinical Trial.
We evaluated the relationship between erythropoietin concentrations and neurodevelopmental outcome in extremely low birth weight infants. ...Close follow-up of infants who are enrolled in large, multicenter, high-dose erythropoietin …
We evaluated the relationship between erythropoietin concentrations and neurodevelopmental outcome in extremely …
Enteral Iron Supplementation in Infants Born Extremely Preterm and its Positive Correlation with Neurodevelopment; Post Hoc Analysis of the Preterm Erythropoietin Neuroprotection Trial Randomized Controlled Trial.
German KR, Vu PT, Comstock BA, Ohls RK, Heagerty PJ, Mayock DE, Georgieff M, Rao R, Juul SE; PENUT Consortium. German KR, et al. J Pediatr. 2021 Nov;238:102-109.e8. doi: 10.1016/j.jpeds.2021.07.019. Epub 2021 Jul 27. J Pediatr. 2021. PMID: 34324880 Free PMC article. Clinical Trial.
OBJECTIVES: To test whether an increased iron dose is associated with improved neurodevelopment as assessed by the Bayley Scales of Infant Development, third edition (BSID-III) among infants enrolled in the Preterm Erythropoietin (Epo) Neuroprot …
OBJECTIVES: To test whether an increased iron dose is associated with improved neurodevelopment as assessed by the Bayley Scales of …
Neuroprotective potential of erythropoietin in neonates; design of a randomized trial.
Juul SE, Mayock DE, Comstock BA, Heagerty PJ. Juul SE, et al. Matern Health Neonatol Perinatol. 2015 Dec 2;1:27. doi: 10.1186/s40748-015-0028-z. eCollection 2015. Matern Health Neonatol Perinatol. 2015. PMID: 27057344 Free PMC article. Review.
These infants, termed Extremely Low Gestational Age Neonates (ELGANs), experience high morbidity and mortality despite modern therapies: approximately 20 % of ELGANs admitted to an NICU die before discharge, 20 % of survivors have severe, and 20 % moderate neurod …
These infants, termed Extremely Low Gestational Age Neonates (ELGANs), experience high morbidity and mortality despite modern …
Early High-Dose Erythropoietin and Cognitive Functions of School-Aged Children Born Very Preterm.
Wehrle FM, Held U, Disselhoff V, Schnider B, Stöckli A, Toma M, Bucher HU, Fauchère JC, Natalucci G, Hüppi P, Borradori-Tolsa C, Liverani MC, O'Gorman RL, Latal B, Hagmann CF. Wehrle FM, et al. JAMA Netw Open. 2024 Sep 3;7(9):e2430043. doi: 10.1001/jamanetworkopen.2024.30043. JAMA Netw Open. 2024. PMID: 39254979
IMPORTANCE: Children born very preterm are at risk for long-term neurodevelopmental sequelae. Prophylactic high-dose recombinant human erythropoietin (rhEpo) shortly after birth has not been shown to improve cognitive, motor, and behavioral development …
IMPORTANCE: Children born very preterm are at risk for long-term neurodevelopmental sequelae. Prophylactic high-dose recombina …
Long-term neuroprotective effect of erythropoietin on executive functions in very preterm children (EpoKids): protocol of a prospective follow-up study.
Wehrle FM, Held U, O'Gorman RT, Disselhoff V, Schnider B, Fauchère JC, Hüppi P, Latal B, Hagmann CF. Wehrle FM, et al. BMJ Open. 2018 Apr 24;8(4):e022157. doi: 10.1136/bmjopen-2018-022157. BMJ Open. 2018. PMID: 29691250 Free PMC article.
The worldwide first randomised interventional multicentre trial investigating the neuroprotective effects of erythropoietin (entitled 'Does erythropoietin improve outcome in very preterm infants?' ...Despite these promising imaging findin …
The worldwide first randomised interventional multicentre trial investigating the neuroprotective effects of erythropoietin (entitled …
Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial.
Vu PT, Ohls RK, Mayock DE, German KR, Comstock BA, Heagerty PJ, Juul SE; PENUT Consortium. Vu PT, et al. Pediatr Res. 2021 Jul;90(1):109-116. doi: 10.1038/s41390-020-01273-w. Epub 2021 Jan 11. Pediatr Res. 2021. PMID: 33432157 Free PMC article. Clinical Trial.
We investigated the impact of transfusions on neurodevelopmental outcome in the Preterm Erythropoietin (Epo) Neuroprotection (PENUT) Trial population. ...The impact of neonatal packed red blood cell transfusions on the neurodevelopmental outc …
We investigated the impact of transfusions on neurodevelopmental outcome in the Preterm Erythropoietin (Epo) Neu …