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Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis.
Esberg A, Huang B, Johansson MJ, Byström AS. Esberg A, et al. Mol Cell. 2006 Oct 6;24(1):139-48. doi: 10.1016/j.molcel.2006.07.031. Mol Cell. 2006. PMID: 17018299
The Kluyveromyces lactis gamma-toxin targets tRNA anticodons.
Lu J, Huang B, Esberg A, Johansson MJ, Byström AS. Lu J, et al. Among authors: esberg a. RNA. 2005 Nov;11(11):1648-54. doi: 10.1261/rna.2172105. RNA. 2005. PMID: 16244131 Free PMC article.
Kluyveromyces lactis killer strains secrete a heterotrimeric toxin (zymocin), which causes an irreversible growth arrest of sensitive yeast cells. ...Transfer RNA lacking a part of or the entire mcm(5) group is inefficiently cleaved by gamma-toxin, explaining the ga …
Kluyveromyces lactis killer strains secrete a heterotrimeric toxin (zymocin), which causes an irreversible growth arrest of sensitive …
Kluyveromyces lactis gamma-toxin, a ribonuclease that recognizes the anticodon stem loop of tRNA.
Lu J, Esberg A, Huang B, Byström AS. Lu J, et al. Among authors: esberg a. Nucleic Acids Res. 2008 Mar;36(4):1072-80. doi: 10.1093/nar/gkm1121. Epub 2007 Dec 20. Nucleic Acids Res. 2008. PMID: 18096622 Free PMC article.
In [see text], the nucleotides U(34)U(35)C(36)A(37)C(38) are required for optimal gamma-toxin cleavage, whereas a purine at position 32 or a G in position 33 dramatically reduces the cleavage of the ASL. Comparing modified and partially modified forms of E. c …
In [see text], the nucleotides U(34)U(35)C(36)A(37)C(38) are required for optimal gamma-toxin cleavage, whereas a purine at po …
Eukaryotic wobble uridine modifications promote a functionally redundant decoding system.
Johansson MJ, Esberg A, Huang B, Björk GR, Byström AS. Johansson MJ, et al. Among authors: esberg a. Mol Cell Biol. 2008 May;28(10):3301-12. doi: 10.1128/MCB.01542-07. Epub 2008 Mar 10. Mol Cell Biol. 2008. PMID: 18332122 Free PMC article.
Uridines located at the wobble position (nucleoside 34 [U(34)]) in eukaryotic cytoplasmic tRNAs often harbor a 5-methoxycarbonylmethyl (mcm(5)) or a 5-carbamoylmethyl (ncm(5)) side chain and sometimes an additional 2-thio (s(2)) or 2'-O-methyl group. Although a
Uridines located at the wobble position (nucleoside 34 [U(34)]) in eukaryotic cytoplasmic tRNAs often harbor a 5-methoxycarbonylmethy …
Iwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae.
Esberg A, Moqtaderi Z, Fan X, Lu J, Struhl K, Byström A. Esberg A, et al. PLoS One. 2011;6(6):e20829. doi: 10.1371/journal.pone.0020829. Epub 2011 Jun 10. PLoS One. 2011. PMID: 21695216 Free PMC article.
BACKGROUND: Iwr1, a protein conserved throughout eukaryotes, was originally identified by its physical interaction with RNA polymerase (Pol) II. PRINCIPAL FINDINGS: Here, we identify Iwr1 in a genetic screen designed to uncover proteins involved in Pol III transcrip …
BACKGROUND: Iwr1, a protein conserved throughout eukaryotes, was originally identified by its physical interaction with RNA polymeras …
The role of wobble uridine modifications in +1 translational frameshifting in eukaryotes.
Tükenmez H, Xu H, Esberg A, Byström AS. Tükenmez H, et al. Among authors: esberg a. Nucleic Acids Res. 2015 Oct 30;43(19):9489-99. doi: 10.1093/nar/gkv832. Epub 2015 Aug 17. Nucleic Acids Res. 2015. PMID: 26283182 Free PMC article.
The latter may be caused by a ternary complex (aminoacyl-tRNA*eEF1A*GTP) with a modification deficient tRNA inefficiently being accepted to the ribosomal A-site and thereby allowing an increased peptidyl-tRNA slippage and thus a frameshift error. In th …
The latter may be caused by a ternary complex (aminoacyl-tRNA*eEF1A*GTP) with a modification deficient tRNA inefficiently bein …
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence.
Bugaytsova JA, Björnham O, Chernov YA, Gideonsson P, Henriksson S, Mendez M, Sjöström R, Mahdavi J, Shevtsova A, Ilver D, Moonens K, Quintana-Hayashi MP, Moskalenko R, Aisenbrey C, Bylund G, Schmidt A, Åberg A, Brännström K, Königer V, Vikström S, Rakhimova L, Hofer A, Ögren J, Liu H, Goldman MD, Whitmire JM, Ådén J, Younson J, Kelly CG, Gilman RH, Chowdhury A, Mukhopadhyay AK, Nair GB, Papadakos KS, Martinez-Gonzalez B, Sgouras DN, Engstrand L, Unemo M, Danielsson D, Suerbaum S, Oscarson S, Morozova-Roche LA, Olofsson A, Gröbner G, Holgersson J, Esberg A, Strömberg N, Landström M, Eldridge AM, Chromy BA, Hansen LM, Solnick JV, Lindén SK, Haas R, Dubois A, Merrell DS, Schedin S, Remaut H, Arnqvist A, Berg DE, Borén T. Bugaytsova JA, et al. Among authors: esberg a. Cell Host Microbe. 2017 Mar 8;21(3):376-389. doi: 10.1016/j.chom.2017.02.013. Cell Host Microbe. 2017. PMID: 28279347 Free PMC article.
Host and bacterial phenotype variation in adhesion of Streptococcus mutans to matched human hosts.
Esberg A, Löfgren-Burström A, Ohman U, Strömberg N. Esberg A, et al. Infect Immun. 2012 Nov;80(11):3869-79. doi: 10.1128/IAI.00435-12. Epub 2012 Aug 27. Infect Immun. 2012. PMID: 22927045 Free PMC article.
The isolates also varied, although less so, in adhesion to standardized saliva (18% adhesion range) and clustered into three major AgI/II groups (groups A, B(1), and B(2)) due to two variable V-region segments and diverse AgI/II sequence types due to a set of single …
The isolates also varied, although less so, in adhesion to standardized saliva (18% adhesion range) and clustered into three major AgI/II gr …
Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development.
Esberg A, Sheng N, Mårell L, Claesson R, Persson K, Borén T, Strömberg N. Esberg A, et al. EBioMedicine. 2017 Oct;24:205-215. doi: 10.1016/j.ebiom.2017.09.027. Epub 2017 Sep 21. EBioMedicine. 2017. PMID: 28958656 Free PMC article.
Dental caries, which affects billions of people, is a chronic infectious disease that involves Streptococcus mutans, which is nevertheless a poor predictor of individual caries development. ...SpaP A, B or C) and collagen (i.e. Cnm, Cbm) match and predict ind …
Dental caries, which affects billions of people, is a chronic infectious disease that involves Streptococcus mutans, which is neverth …
Genomic structure of and genome-wide recombination in the Saccharomyces cerevisiae S288C progenitor isolate EM93.
Esberg A, Muller LA, McCusker JH. Esberg A, et al. PLoS One. 2011;6(9):e25211. doi: 10.1371/journal.pone.0025211. Epub 2011 Sep 26. PLoS One. 2011. PMID: 21966457 Free PMC article.
In this study, we generate a high-resolution overview of the genetic differences between EM93 and S288C. We show that EM93 is heterozygous for >45,000 polymorphisms, including large sequence polymorphisms, such as deletions and a Saccharomyces paradoxus introgres …
In this study, we generate a high-resolution overview of the genetic differences between EM93 and S288C. We show that EM93 is heteroz …
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