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Changes in endocannabinoid receptors and enzymes in the spinal cord of SOD1(G93A) transgenic mice and evaluation of a Sativex(®) -like combination of phytocannabinoids: interest for future therapies in amyotrophic lateral sclerosis.
Moreno-Martet M, Espejo-Porras F, Fernández-Ruiz J, de Lago E. Moreno-Martet M, et al. Among authors: espejo porras f. CNS Neurosci Ther. 2014 Sep;20(9):809-15. doi: 10.1111/cns.12262. Epub 2014 Apr 7. CNS Neurosci Ther. 2014. PMID: 24703394 Free PMC article.
Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors.
Espejo-Porras F, Fernández-Ruiz J, Pertwee RG, Mechoulam R, García C. Espejo-Porras F, et al. Neuropharmacology. 2013 Dec;75:155-63. doi: 10.1016/j.neuropharm.2013.07.024. Epub 2013 Aug 4. Neuropharmacology. 2013. PMID: 23924692
Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders.
Espejo-Porras F, Piscitelli F, Verde R, Ramos JA, Di Marzo V, de Lago E, Fernández-Ruiz J. Espejo-Porras F, et al. J Neuroimmune Pharmacol. 2015 Jun;10(2):233-44. doi: 10.1007/s11481-015-9602-4. Epub 2015 Mar 29. J Neuroimmune Pharmacol. 2015. PMID: 25819934 Review.
The disease-modifying effects of a Sativex-like combination of phytocannabinoids in mice with experimental autoimmune encephalomyelitis are preferentially due to Δ9-tetrahydrocannabinol acting through CB1 receptors.
Moreno-Martet M, Feliú A, Espejo-Porras F, Mecha M, Carrillo-Salinas FJ, Fernández-Ruiz J, Guaza C, de Lago E. Moreno-Martet M, et al. Among authors: espejo porras f. Mult Scler Relat Disord. 2015 Nov;4(6):505-11. doi: 10.1016/j.msard.2015.08.001. Epub 2015 Aug 5. Mult Scler Relat Disord. 2015. PMID: 26590655
Upregulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis.
Fernández-Trapero M, Espejo-Porras F, Rodríguez-Cueto C, Coates JR, Pérez-Díaz C, de Lago E, Fernández-Ruiz J. Fernández-Trapero M, et al. Among authors: espejo porras f. Dis Model Mech. 2017 May 1;10(5):551-558. doi: 10.1242/dmm.028373. Epub 2017 Jan 9. Dis Model Mech. 2017. PMID: 28069688 Free PMC article.
Analysis of endocannabinoid receptors and enzymes in the post-mortem motor cortex and spinal cord of amyotrophic lateral sclerosis patients.
Espejo-Porras F, Fernández-Ruiz J, de Lago E. Espejo-Porras F, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):377-386. doi: 10.1080/21678421.2018.1425454. Epub 2018 Jan 15. Amyotroph Lateral Scler Frontotemporal Degener. 2018. PMID: 29334787
Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis.
Espejo-Porras F, García-Toscano L, Rodríguez-Cueto C, Santos-García I, de Lago E, Fernandez-Ruiz J. Espejo-Porras F, et al. Br J Pharmacol. 2019 May;176(10):1585-1600. doi: 10.1111/bph.14216. Epub 2018 May 6. Br J Pharmacol. 2019. PMID: 29574689 Free PMC article.
Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis.
Rodríguez-Cueto C, Santos-García I, García-Toscano L, Espejo-Porras F, Bellido M, Fernández-Ruiz J, Muñoz E, de Lago E. Rodríguez-Cueto C, et al. Among authors: espejo porras f. Biochem Pharmacol. 2018 Nov;157:217-226. doi: 10.1016/j.bcp.2018.07.049. Epub 2018 Aug 1. Biochem Pharmacol. 2018. PMID: 30076846
Pharmacokinetics of Sativex® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders.
Fernández-Trapero M, Pérez-Díaz C, Espejo-Porras F, de Lago E, Fernández-Ruiz J. Fernández-Trapero M, et al. Among authors: espejo porras f. Biomolecules. 2020 Feb 11;10(2):279. doi: 10.3390/biom10020279. Biomolecules. 2020. PMID: 32054131 Free PMC article.
Elevated exosomal secretion of miR-124-3p from spinal neurons positively associates with disease severity in ALS.
Yelick J, Men Y, Jin S, Seo S, Espejo-Porras F, Yang Y. Yelick J, et al. Among authors: espejo porras f. Exp Neurol. 2020 Jul 24;333:113414. doi: 10.1016/j.expneurol.2020.113414. Online ahead of print. Exp Neurol. 2020. PMID: 32712030
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