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NADPH oxidase and hydrogen peroxide mediate insulin-induced calcium increase in skeletal muscle cells.
Espinosa A, García A, Härtel S, Hidalgo C, Jaimovich E. Espinosa A, et al. J Biol Chem. 2009 Jan 23;284(4):2568-75. doi: 10.1074/jbc.M804249200. Epub 2008 Nov 20. J Biol Chem. 2009. PMID: 19028699
Skeletal muscle is one of the main physiological targets of insulin, a hormone that triggers a complex signaling cascade and that enhances the production of reactive oxygen species (ROS) in different cell types. ...We used the translocation of p47phox from the cytop …
Skeletal muscle is one of the main physiological targets of insulin, a hormone that triggers a complex signaling cascade and t …
Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells.
Estrada M, Espinosa A, Müller M, Jaimovich E. Estrada M, et al. Endocrinology. 2003 Aug;144(8):3586-97. doi: 10.1210/en.2002-0164. Endocrinology. 2003. PMID: 12865341
These results are consistent with a fast effect of testosterone, involving a G protein-linked receptor at the plasma membrane, IP(3)-mediated Ca(2+) signal, and the Ras/MEK/ERK pathway in muscle cells....
These results are consistent with a fast effect of testosterone, involving a G protein-linked receptor at the plasma membrane, …
IGF-I and insulin induce different intracellular calcium signals in skeletal muscle cells.
Espinosa A, Estrada M, Jaimovich E. Espinosa A, et al. J Endocrinol. 2004 Aug;182(2):339-52. doi: 10.1677/joe.0.1820339. J Endocrinol. 2004. PMID: 15283694
IGF-I induced a fast and transient Ca(2+) increase, measured as fluo-3 fluorescence. This response was blocked by both genistein and AG538. IGF-I induced a fast inositol-1,4,5-trisphosphate (IP(3)) increase, kinetically similar to the Ca(2+) rise. The Ca(2+) signal …
IGF-I induced a fast and transient Ca(2+) increase, measured as fluo-3 fluorescence. This response was blocked by both genistein and …
Capacitative calcium entry in testosterone-induced intracellular calcium oscillations in myotubes.
Estrada M, Espinosa A, Gibson CJ, Uhlen P, Jaimovich E. Estrada M, et al. J Endocrinol. 2005 Feb;184(2):371-9. doi: 10.1677/joe.1.05921. J Endocrinol. 2005. PMID: 15684345
Testosterone (100 nM) rapidly induced an intracellular Ca2+ rise, accompanied by Ca2+ oscillations in a majority of myotubes. ...Intracellular Ca2+ store depletion in Ca(2+)-free medium, using a sarcoplasmic/endoplasmic reticulum calcium ATPase-pump inhibitor, follo …
Testosterone (100 nM) rapidly induced an intracellular Ca2+ rise, accompanied by Ca2+ oscillations in a majority of myotubes. ...Intr …
Possible link of different slow calcium signals generated by membrane potential and hormones to differential gene expression in cultured muscle cells.
Jaimovich E, Espinosa A. Jaimovich E, et al. Biol Res. 2004;37(4):625-33. doi: 10.4067/s0716-97602004000400018. Biol Res. 2004. PMID: 15709691
Insulin produced a fast (< 1 s) and transient [Ca2+] increase lasting less than 10 s. IGF-I induced a transient [Ca2+] increase, reaching a fluorescence peak 6 s after stimulus, to return to basal values after 60 s. ...
Insulin produced a fast (< 1 s) and transient [Ca2+] increase lasting less than 10 s. IGF-I induced a transient [Ca2+] incr …
Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes.
Espinosa A, Leiva A, Peña M, Müller M, Debandi A, Hidalgo C, Carrasco MA, Jaimovich E. Espinosa A, et al. J Cell Physiol. 2006 Nov;209(2):379-88. doi: 10.1002/jcp.20745. J Cell Physiol. 2006. PMID: 16897752
We determined ROS generation in primary cultures of rat skeletal muscle after field stimulation (400 1-ms pulses at a frequency of 45 Hz) or after depolarization with 65 mM K+ for 1 min. Both protocols induced a long lasting increase in dichlorofluorescein fluoresce …
We determined ROS generation in primary cultures of rat skeletal muscle after field stimulation (400 1-ms pulses at a frequency of 45 …
Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kγ-Akt-AS160 in skeletal muscle cells.
Osorio-Fuentealba C, Contreras-Ferrat AE, Altamirano F, Espinosa A, Li Q, Niu W, Lavandero S, Klip A, Jaimovich E. Osorio-Fuentealba C, et al. Diabetes. 2013 May;62(5):1519-26. doi: 10.2337/db12-1066. Epub 2012 Dec 28. Diabetes. 2013. PMID: 23274898 Free PMC article.
Insulin-dependent H2O2 production is higher in muscle fibers of mice fed with a high-fat diet.
Espinosa A, Campos C, Díaz-Vegas A, Galgani JE, Juretic N, Osorio-Fuentealba C, Bucarey JL, Tapia G, Valenzuela R, Contreras-Ferrat A, Llanos P, Jaimovich E. Espinosa A, et al. Int J Mol Sci. 2013 Jul 29;14(8):15740-54. doi: 10.3390/ijms140815740. Int J Mol Sci. 2013. PMID: 23899788 Free PMC article.
Insulin resistance is defined as a reduced ability of insulin to stimulate glucose utilization. C57BL/6 mice fed with a high-fat diet (HFD) are a model of insulin resistance. ...
Insulin resistance is defined as a reduced ability of insulin to stimulate glucose utilization. C57BL/6 mice fed with a high-f …
Insulin elicits a ROS-activated and an IP₃-dependent Ca²⁺ release, which both impinge on GLUT4 translocation.
Contreras-Ferrat A, Llanos P, Vásquez C, Espinosa A, Osorio-Fuentealba C, Arias-Calderon M, Lavandero S, Klip A, Hidalgo C, Jaimovich E. Contreras-Ferrat A, et al. J Cell Sci. 2014 May 1;127(Pt 9):1911-23. doi: 10.1242/jcs.138982. Epub 2014 Feb 25. J Cell Sci. 2014. PMID: 24569874
A ryanodine receptor (RyR) channel agonist stimulated GLUT4myc translocation and insulin stimulated RyR1-mediated Ca(2+) release by promoting RyR1 S-glutathionylation. ...
A ryanodine receptor (RyR) channel agonist stimulated GLUT4myc translocation and insulin stimulated RyR1-mediated Ca(2+) release by p
The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice.
Llanos P, Contreras-Ferrat A, Georgiev T, Osorio-Fuentealba C, Espinosa A, Hidalgo J, Hidalgo C, Jaimovich E. Llanos P, et al. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E294-305. doi: 10.1152/ajpendo.00189.2014. Epub 2014 Dec 9. Am J Physiol Endocrinol Metab. 2015. PMID: 25491723
Additionally, isolated muscle fibers (flexor digitorum brevis) from HFD-fed mice showed a 40% decrease in insulin-stimulated glucose uptake rates compared with fibers from control mice. ...Our findings suggest that T-tubule cholesterol content exerts a critical regu …
Additionally, isolated muscle fibers (flexor digitorum brevis) from HFD-fed mice showed a 40% decrease in insulin-stimulated glucose …
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