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ADAM17 as a therapeutic target in multiple diseases.
Arribas J, Esselens C. Arribas J, et al. Among authors: esselens c. Curr Pharm Des. 2009;15(20):2319-35. doi: 10.2174/138161209788682398. Curr Pharm Des. 2009. PMID: 19601834 Review.
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.
Esselens CW, Malapeira J, Colomé N, Moss M, Canals F, Arribas J. Esselens CW, et al. Biol Chem. 2008 Aug;389(8):1075-84. doi: 10.1515/bc.2008.121. Biol Chem. 2008. PMID: 18979631
ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin.
Malapeira J, Esselens C, Bech-Serra JJ, Canals F, Arribas J. Malapeira J, et al. Among authors: esselens c. Oncogene. 2011 Apr 21;30(16):1912-22. doi: 10.1038/onc.2010.565. Epub 2010 Dec 20. Oncogene. 2011. PMID: 21170088
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.
Bech-Serra JJ, Santiago-Josefat B, Esselens C, Saftig P, Baselga J, Arribas J, Canals F. Bech-Serra JJ, et al. Among authors: esselens c. Mol Cell Biol. 2006 Jul;26(13):5086-95. doi: 10.1128/MCB.02380-05. Mol Cell Biol. 2006. PMID: 16782893 Free PMC article.
Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors.
Santiago-Josefat B, Esselens C, Bech-Serra JJ, Arribas J. Santiago-Josefat B, et al. Among authors: esselens c. J Biol Chem. 2007 Mar 16;282(11):8325-31. doi: 10.1074/jbc.M608826200. Epub 2007 Jan 16. J Biol Chem. 2007. PMID: 17227756 Free article.
The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration.
Esselens C, Malapeira J, Colomé N, Casal C, Rodríguez-Manzaneque JC, Canals F, Arribas J. Esselens C, et al. J Biol Chem. 2010 Jan 22;285(4):2463-73. doi: 10.1074/jbc.M109.055129. Epub 2009 Nov 13. J Biol Chem. 2010. PMID: 19915008 Free PMC article.
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W. Esselens C, et al. J Cell Biol. 2004 Sep 27;166(7):1041-54. doi: 10.1083/jcb.200406060. J Cell Biol. 2004. PMID: 15452145 Free PMC article.
Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.
De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B. De Jonghe C, et al. Hum Mol Genet. 2001 Aug 1;10(16):1665-71. doi: 10.1093/hmg/10.16.1665. Hum Mol Genet. 2001. PMID: 11487570
In addition, a subset of mutations caused the accumulation of APP C-terminal fragments indicating that these mutations also influence the stability of APP C-terminal fragments. ...
In addition, a subset of mutations caused the accumulation of APP C-terminal fragments indicating that these mutations also influence …
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.
Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, Vints K, Baatsen P, Munck S, Derua R, Waelkens E, Basi GS, Mercken M, Vooijs M, Bollen M, Schymkowitz J, Rousseau F, Bonifacino JS, Van Niel G, De Strooper B, Annaert W. Sannerud R, et al. Among authors: esselens c. Cell. 2016 Jun 30;166(1):193-208. doi: 10.1016/j.cell.2016.05.020. Epub 2016 Jun 9. Cell. 2016. PMID: 27293189 Free PMC article.
Presenilin 1: more than just gamma-secretase.
Raemaekers T, Esselens C, Annaert W. Raemaekers T, et al. Among authors: esselens c. Biochem Soc Trans. 2005 Aug;33(Pt 4):559-62. doi: 10.1042/BST0330559. Biochem Soc Trans. 2005. PMID: 16042544 Review.
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