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Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.
Vallon M, Essler M. Vallon M, et al. J Biol Chem. 2006 Nov 10;281(45):34179-88. doi: 10.1074/jbc.M605291200. Epub 2006 Sep 17. J Biol Chem. 2006. PMID: 16982628
Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase.
Essler M, Retzer M, Bauer M, Heemskerk JW, Aepfelbacher M, Siess W. Essler M, et al. J Biol Chem. 1999 Oct 22;274(43):30361-4. doi: 10.1074/jbc.274.43.30361. J Biol Chem. 1999. PMID: 10521411
In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's disease.
Schultheiss C, Blechert B, Gaertner FC, Drecoll E, Mueller J, Weber GF, Drzezga A, Essler M. Schultheiss C, et al. Angiogenesis. 2006;9(2):59-65. doi: 10.1007/s10456-006-9030-4. Epub 2006 Jul 5. Angiogenesis. 2006. PMID: 16821113
Targeting of tumor blood vessels: a phage-displayed tumor-homing peptide specifically binds to matrix metalloproteinase-2-processed collagen IV and blocks angiogenesis in vivo.
Mueller J, Gaertner FC, Blechert B, Janssen KP, Essler M. Mueller J, et al. Mol Cancer Res. 2009 Jul;7(7):1078-85. doi: 10.1158/1541-7786.MCR-08-0538. Epub 2009 Jul 7. Mol Cancer Res. 2009. PMID: 19584266
Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation.
Vallon M, Rohde F, Janssen KP, Essler M. Vallon M, et al. Exp Cell Res. 2010 Feb 1;316(3):412-21. doi: 10.1016/j.yexcr.2009.10.013. Epub 2009 Oct 21. Exp Cell Res. 2010. PMID: 19853600
Alpha-particle emitting 213Bi-anti-EGFR immunoconjugates eradicate tumor cells independent of oxygenation.
Wulbrand C, Seidl C, Gaertner FC, Bruchertseifer F, Morgenstern A, Essler M, Senekowitsch-Schmidtke R. Wulbrand C, et al. PLoS One. 2013 May 28;8(5):e64730. doi: 10.1371/journal.pone.0064730. Print 2013. PLoS One. 2013. PMID: 23724085 Free PMC article.
Rho is a negative regulator of human monocyte spreading.
Aepfelbacher M, Essler M, Huber E, Czech A, Weber PC. Aepfelbacher M, et al. J Immunol. 1996 Dec 1;157(11):5070-5. J Immunol. 1996. PMID: 8943416
IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase.
Weber GF, Gaertner FC, Erl W, Janssen KP, Blechert B, Holzmann B, Weighardt H, Essler M. Weber GF, et al. J Immunol. 2006 Dec 1;177(11):8266-72. doi: 10.4049/jimmunol.177.11.8266. J Immunol. 2006. PMID: 17114505
Furthermore, IL-22 induced a cell cycle arrest of EMT6 cells in the G(2)-M phase. IL-22 reduced EMT6 cell numbers and the proliferation rate by approximately 50% as measured by [(3)H]thymidine incorporation. ...
Furthermore, IL-22 induced a cell cycle arrest of EMT6 cells in the G(2)-M phase. IL-22 reduced EMT6 cell numbers and the proliferati …
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