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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 1
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2012 11
2013 11
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2018 7
2019 12
2020 6
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2022 7
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GCTA: a tool for genome-wide complex trait analysis.
Yang J, Lee SH, Goddard ME, Visscher PM. Yang J, et al. Am J Hum Genet. 2011 Jan 7;88(1):76-82. doi: 10.1016/j.ajhg.2010.11.011. Epub 2010 Dec 17. Am J Hum Genet. 2011. PMID: 21167468 Free PMC article.
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly software tool called genome-wide complex …
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) exp …
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.
Wainschtein P, Jain D, Zheng Z; TOPMed Anthropometry Working Group; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Cupples LA, Shadyab AH, McKnight B, Shoemaker BM, Mitchell BD, Psaty BM, Kooperberg C, Liu CT, Albert CM, Roden D, Chasman DI, Darbar D, Lloyd-Jones DM, Arnett DK, Regan EA, Boerwinkle E, Rotter JI, O'Connell JR, Yanek LR, de Andrade M, Allison MA, McDonald MN, Chung MK, Fornage M, Chami N, Smith NL, Ellinor PT, Vasan RS, Mathias RA, Loos RJF, Rich SS, Lubitz SA, Heckbert SR, Redline S, Guo X, Chen Y-I, Laurie CA, Hernandez RD, McGarvey ST, Goddard ME, Laurie CC, North KE, Lange LA, Weir BS, Yengo L, Yang J, Visscher PM. Wainschtein P, et al. Nat Genet. 2022 Mar;54(3):263-273. doi: 10.1038/s41588-021-00997-7. Epub 2022 Mar 7. Nat Genet. 2022. PMID: 35256806 Free PMC article.
Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits and diseases, approximately one-third to two-thirds of heritability is captured by common SNPs. ...Here we estimated
Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits …
Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing.
Lalami I, Abo C, Borghese B, Chapron C, Vaiman D. Lalami I, et al. Int J Mol Sci. 2021 Jul 7;22(14):7297. doi: 10.3390/ijms22147297. Int J Mol Sci. 2021. PMID: 34298916 Free PMC article. Review.
From 2010, large Genome Wide Association Studies (GWAS), aimed at identifying the genes and loci underlying this genetic determinism. ...While a handful of chromosome regions and genes have clearly been identified and statistically demonstrated as at-r …
From 2010, large Genome Wide Association Studies (GWAS), aimed at identifying the genes and loci underlying this …
Estimating missing heritability for disease from genome-wide association studies.
Lee SH, Wray NR, Goddard ME, Visscher PM. Lee SH, et al. Am J Hum Genet. 2011 Mar 11;88(3):294-305. doi: 10.1016/j.ajhg.2011.02.002. Epub 2011 Mar 3. Am J Hum Genet. 2011. PMID: 21376301 Free PMC article.
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. ...Here we develop this method further for case-control studies. We use a linear mixed model for analysis of binary traits and transform the
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. ...Here
Genetic risk factors and gene-environment interactions in adult and childhood attention-deficit/hyperactivity disorder.
Palladino VS, McNeill R, Reif A, Kittel-Schneider S. Palladino VS, et al. Psychiatr Genet. 2019 Jun;29(3):63-78. doi: 10.1097/YPG.0000000000000220. Psychiatr Genet. 2019. PMID: 30741787 Review.
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder. In recent years, genetic studies have revealed several risk gene variants associated with ADHD; however, these variants could only be partly replicated and …
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder. In recent years, geneti …
Heritability in inflammatory bowel disease: from the first twin study to genome-wide association studies.
Gordon H, Trier Moller F, Andersen V, Harbord M. Gordon H, et al. Inflamm Bowel Dis. 2015 Jun;21(6):1428-34. doi: 10.1097/MIB.0000000000000393. Inflamm Bowel Dis. 2015. PMID: 25895112 Free PMC article. Review.
Heritability estimates for Crohn's disease and ulcerative colitis from pooled twin studies are 0.75 and 0.67, respectively. However, this is at odds with the much lower heritability estimates from Genome-Wide Assoc
Heritability estimates for Crohn's disease and ulcerative colitis from pooled twin studies are 0.75 and 0
Re-assessment of multiple testing strategies for more efficient genome-wide association studies.
Otani T, Noma H, Nishino J, Matsui S. Otani T, et al. Eur J Hum Genet. 2018 Jul;26(7):1038-1048. doi: 10.1038/s41431-018-0125-3. Epub 2018 Mar 9. Eur J Hum Genet. 2018. PMID: 29523830 Free PMC article.
Although enormous costs have been dedicated to discovering relevant disease-related genetic variants, especially in genome-wide association studies (GWASs), only a small fraction of estimated heritability can be explained by these …
Although enormous costs have been dedicated to discovering relevant disease-related genetic variants, especially in genome- …
Heritability in the genome-wide association era.
Zaitlen N, Kraft P. Zaitlen N, et al. Hum Genet. 2012 Oct;131(10):1655-64. doi: 10.1007/s00439-012-1199-6. Epub 2012 Jul 21. Hum Genet. 2012. PMID: 22821350 Free PMC article. Review.
The gap between the phenotypic variance explained by GWAS results and those estimated from classical heritability methods has been termed the "missing heritability problem". In this work, we examine modern methods for estimating heritability
The gap between the phenotypic variance explained by GWAS results and those estimated from classical heritability methods has …
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Büchel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, Guerreiro R, Hernandez DG, Brice A, Ylikotila P, Stefánsson H, Majamaa K, Morris HR, Williams N, Gasser T, Heutink P, Wood NW, Hardy J, Martinez M, Singleton AB, Nalls MA; International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2). Keller MF, et al. Hum Mol Genet. 2012 Nov 15;21(22):4996-5009. doi: 10.1093/hmg/dds335. Epub 2012 Aug 13. Hum Mol Genet. 2012. PMID: 22892372 Free PMC article.
Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with common traits remains unacc
Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNP
Regional heritability mapping and genome-wide association identify loci for complex growth, wood and disease resistance traits in Eucalyptus.
Resende RT, Resende MD, Silva FF, Azevedo CF, Takahashi EK, Silva-Junior OB, Grattapaglia D. Resende RT, et al. New Phytol. 2017 Feb;213(3):1287-1300. doi: 10.1111/nph.14266. Epub 2016 Nov 7. New Phytol. 2017. PMID: 28079935 Free article.
Although genome-wide association studies (GWAS) have provided valuable insights into the decoding of the relationships between sequence variation and complex phenotypes, they have explained little heritability. Regional heritability mappi …
Although genome-wide association studies (GWAS) have provided valuable insights into the decoding of the relatio …
105 results