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Estimating missing heritability for disease from genome-wide association studies.
Lee SH, Wray NR, Goddard ME, Visscher PM. Lee SH, et al. Am J Hum Genet. 2011 Mar 11;88(3):294-305. doi: 10.1016/j.ajhg.2011.02.002. Epub 2011 Mar 3. Am J Hum Genet. 2011. PMID: 21376301 Free PMC article.
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. ...Here we develop this method further for case-control studies. We use a linear mixed model for analysis of binary traits and transform the
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. ...Here
GCTA: a tool for genome-wide complex trait analysis.
Yang J, Lee SH, Goddard ME, Visscher PM. Yang J, et al. Am J Hum Genet. 2011 Jan 7;88(1):76-82. doi: 10.1016/j.ajhg.2010.11.011. Epub 2010 Dec 17. Am J Hum Genet. 2011. PMID: 21167468 Free PMC article.
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly software tool called genome-wide complex …
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) exp …
Missing heritability of complex diseases: case solved?
Génin E. Génin E. Hum Genet. 2020 Jan;139(1):103-113. doi: 10.1007/s00439-019-02034-4. Epub 2019 Jun 4. Hum Genet. 2020. PMID: 31165258 Review.
About 10 years ago, after the first large-scale genome-wide association studies (GWAS) were conducted to find genes associated with common complex diseases, investigators were surprised to find that the amount of heritability explained by …
About 10 years ago, after the first large-scale genome-wide association studies (GWAS) were conducted to find ge …
Genetics and intelligence differences: five special findings.
Plomin R, Deary IJ. Plomin R, et al. Mol Psychiatry. 2015 Feb;20(1):98-108. doi: 10.1038/mp.2014.105. Epub 2014 Sep 16. Mol Psychiatry. 2015. PMID: 25224258 Free PMC article. Review.
(v) Intelligence is associated with education and social class and broadens the causal perspectives on how these three inter-correlated variables contribute to social mobility, and health, illness and mortality differences. These five findings arose primarily from twin studies
(v) Intelligence is associated with education and social class and broadens the causal perspectives on how these three inter-correlated vari …
Genetic risk factors and gene-environment interactions in adult and childhood attention-deficit/hyperactivity disorder.
Palladino VS, McNeill R, Reif A, Kittel-Schneider S. Palladino VS, et al. Psychiatr Genet. 2019 Jun;29(3):63-78. doi: 10.1097/YPG.0000000000000220. Psychiatr Genet. 2019. PMID: 30741787 Review.
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder. In recent years, genetic studies have revealed several risk gene variants associated with ADHD; however, these variants could only be partly replicated and …
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder. In recent years, geneti …
Translational genomics and beyond in bipolar disorder.
Zhang C, Xiao X, Li T, Li M. Zhang C, et al. Mol Psychiatry. 2021 Jan;26(1):186-202. doi: 10.1038/s41380-020-0782-9. Epub 2020 May 18. Mol Psychiatry. 2021. PMID: 32424235 Review.
Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring risk of bipolar disorder (BD), providing hints for its underlying pathobiology. ...Where is the "missing heritability"? How can we explain the biology o
Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring risk of bipolar disorder (
Re-assessment of multiple testing strategies for more efficient genome-wide association studies.
Otani T, Noma H, Nishino J, Matsui S. Otani T, et al. Eur J Hum Genet. 2018 Jul;26(7):1038-1048. doi: 10.1038/s41431-018-0125-3. Epub 2018 Mar 9. Eur J Hum Genet. 2018. PMID: 29523830 Free PMC article.
Although enormous costs have been dedicated to discovering relevant disease-related genetic variants, especially in genome-wide association studies (GWASs), only a small fraction of estimated heritability can be explained by these …
Although enormous costs have been dedicated to discovering relevant disease-related genetic variants, especially in genome- …
Heritability in inflammatory bowel disease: from the first twin study to genome-wide association studies.
Gordon H, Trier Moller F, Andersen V, Harbord M. Gordon H, et al. Inflamm Bowel Dis. 2015 Jun;21(6):1428-34. doi: 10.1097/MIB.0000000000000393. Inflamm Bowel Dis. 2015. PMID: 25895112 Free PMC article. Review.
Heritability estimates for Crohn's disease and ulcerative colitis from pooled twin studies are 0.75 and 0.67, respectively. However, this is at odds with the much lower heritability estimates from Genome-Wide Assoc
Heritability estimates for Crohn's disease and ulcerative colitis from pooled twin studies are 0.75 and 0
Common SNPs explain a large proportion of the heritability for human height.
Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Yang J, et al. Nat Genet. 2010 Jul;42(7):565-9. doi: 10.1038/ng.608. Epub 2010 Jun 20. Nat Genet. 2010. PMID: 20562875 Free PMC article.
SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic variation of complex traits in human populations. Where is the remaining heritability? We estimated the proportion of variance for …
SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic vari …
Research review: Polygenic methods and their application to psychiatric traits.
Wray NR, Lee SH, Mehta D, Vinkhuyzen AA, Dudbridge F, Middeldorp CM. Wray NR, et al. J Child Psychol Psychiatry. 2014 Oct;55(10):1068-87. doi: 10.1111/jcpp.12295. Epub 2014 Aug 1. J Child Psychol Psychiatry. 2014. PMID: 25132410 Review.
We review results of applications of the methods to psychiatric disorders and related traits and consider how these methods inform on missing heritability, hidden heritability and still-missing heritability. FINDINGS: Genome-wide g …
We review results of applications of the methods to psychiatric disorders and related traits and consider how these methods inform on mis
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