Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 1
2010 4
2011 6
2012 11
2013 11
2014 15
2015 17
2016 8
2017 10
2018 7
2019 12
2020 6
2021 6
2022 7
2023 3
2024 6

Text availability

Article attribute

Article type

Publication date

Search Results

114 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
GCTA: a tool for genome-wide complex trait analysis.
Yang J, Lee SH, Goddard ME, Visscher PM. Yang J, et al. Am J Hum Genet. 2011 Jan 7;88(1):76-82. doi: 10.1016/j.ajhg.2010.11.011. Epub 2010 Dec 17. Am J Hum Genet. 2011. PMID: 21167468 Free PMC article.
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly software tool called genome-wide complex …
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) exp …
The complex genetic architecture of Alzheimer's disease: novel insights and future directions.
Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. Andrews SJ, et al. EBioMedicine. 2023 Apr;90:104511. doi: 10.1016/j.ebiom.2023.104511. Epub 2023 Mar 10. EBioMedicine. 2023. PMID: 36907103 Free PMC article. Review.
AD is highly heritable, with heritability estimates of 70% from twin studies. Progressively larger genome-wide association studies (GWAS) have continued to expand our knowledge of AD/dementia genetic architecture. ...: While …
AD is highly heritable, with heritability estimates of 70% from twin studies. Progressively larger genome …
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.
Wainschtein P, Jain D, Zheng Z; TOPMed Anthropometry Working Group; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Cupples LA, Shadyab AH, McKnight B, Shoemaker BM, Mitchell BD, Psaty BM, Kooperberg C, Liu CT, Albert CM, Roden D, Chasman DI, Darbar D, Lloyd-Jones DM, Arnett DK, Regan EA, Boerwinkle E, Rotter JI, O'Connell JR, Yanek LR, de Andrade M, Allison MA, McDonald MN, Chung MK, Fornage M, Chami N, Smith NL, Ellinor PT, Vasan RS, Mathias RA, Loos RJF, Rich SS, Lubitz SA, Heckbert SR, Redline S, Guo X, Chen Y-I, Laurie CA, Hernandez RD, McGarvey ST, Goddard ME, Laurie CC, North KE, Lange LA, Weir BS, Yengo L, Yang J, Visscher PM. Wainschtein P, et al. Nat Genet. 2022 Mar;54(3):263-273. doi: 10.1038/s41588-021-00997-7. Epub 2022 Mar 7. Nat Genet. 2022. PMID: 35256806 Free PMC article.
Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits and diseases, approximately one-third to two-thirds of heritability is captured by common SNPs. ...Here we estimated …
Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits …
Estimating missing heritability for disease from genome-wide association studies.
Lee SH, Wray NR, Goddard ME, Visscher PM. Lee SH, et al. Am J Hum Genet. 2011 Mar 11;88(3):294-305. doi: 10.1016/j.ajhg.2011.02.002. Epub 2011 Mar 3. Am J Hum Genet. 2011. PMID: 21376301 Free PMC article.
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. ...Recently, we developed a method for quantitative traits that estimates the variation accounted for when fitting all SNPs simultaneously. H …
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. ...Recen …
Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing.
Lalami I, Abo C, Borghese B, Chapron C, Vaiman D. Lalami I, et al. Int J Mol Sci. 2021 Jul 7;22(14):7297. doi: 10.3390/ijms22147297. Int J Mol Sci. 2021. PMID: 34298916 Free PMC article. Review.
Despite the obvious genetic complexity of the disease, analysis of sibs has allowed heritability estimation of endometriosis at ~50%. From 2010, large Genome Wide Association Studies (GWAS), aimed at identifying the genes and loci …
Despite the obvious genetic complexity of the disease, analysis of sibs has allowed heritability estimation of endometr …
Common SNPs explain a large proportion of the heritability for human height.
Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Yang J, et al. Nat Genet. 2010 Jul;42(7):565-9. doi: 10.1038/ng.608. Epub 2010 Jun 20. Nat Genet. 2010. PMID: 20562875 Free PMC article.
SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic variation of complex traits in human populations. Where is the remaining heritability? We estimated the proportion of variance for …
SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic vari …
Heritability in inflammatory bowel disease: from the first twin study to genome-wide association studies.
Gordon H, Trier Moller F, Andersen V, Harbord M. Gordon H, et al. Inflamm Bowel Dis. 2015 Jun;21(6):1428-34. doi: 10.1097/MIB.0000000000000393. Inflamm Bowel Dis. 2015. PMID: 25895112 Free PMC article. Review.
Heritability estimates for Crohn's disease and ulcerative colitis from pooled twin studies are 0.75 and 0.67, respectively. However, this is at odds with the much lower heritability estimates from Genome-Wide Association …
Heritability estimates for Crohn's disease and ulcerative colitis from pooled twin studies are 0.75 and 0.67, re …
Epigenetics of Primary Biliary Cholangitis.
Li Y, Tang R, Ma X. Li Y, et al. Adv Exp Med Biol. 2020;1253:259-283. doi: 10.1007/978-981-15-3449-2_10. Adv Exp Med Biol. 2020. PMID: 32445099 Review.
Recently, genome-wide association studies (GWAS) have identified multiple genes influencing the susceptibility to PBC in HLA and non-HLA loci. However, it is estimated that the known risk variants merely account for no more than 20% of the he …
Recently, genome-wide association studies (GWAS) have identified multiple genes influencing the susceptibility t …
Heritability in the genome-wide association era.
Zaitlen N, Kraft P. Zaitlen N, et al. Hum Genet. 2012 Oct;131(10):1655-64. doi: 10.1007/s00439-012-1199-6. Epub 2012 Jul 21. Hum Genet. 2012. PMID: 22821350 Free PMC article. Review.
The gap between the phenotypic variance explained by GWAS results and those estimated from classical heritability methods has been termed the "missing heritability problem". In this work, we examine modern methods for estimating heritability …
The gap between the phenotypic variance explained by GWAS results and those estimated from classical heritability methods has …
Re-assessment of multiple testing strategies for more efficient genome-wide association studies.
Otani T, Noma H, Nishino J, Matsui S. Otani T, et al. Eur J Hum Genet. 2018 Jul;26(7):1038-1048. doi: 10.1038/s41431-018-0125-3. Epub 2018 Mar 9. Eur J Hum Genet. 2018. PMID: 29523830 Free PMC article.
Although enormous costs have been dedicated to discovering relevant disease-related genetic variants, especially in genome-wide association studies (GWASs), only a small fraction of estimated heritability can be explained by these …
Although enormous costs have been dedicated to discovering relevant disease-related genetic variants, especially in genome- …
114 results