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119 results

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Page 1
GCTA: a tool for genome-wide complex trait analysis.
Yang J, Lee SH, Goddard ME, Visscher PM. Yang J, et al. Am J Hum Genet. 2011 Jan 7;88(1):76-82. doi: 10.1016/j.ajhg.2010.11.011. Epub 2010 Dec 17. Am J Hum Genet. 2011. PMID: 21167468 Free PMC article.
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly software tool called genome-wide complex …
For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) exp …
Genetics and intelligence differences: five special findings.
Plomin R, Deary IJ. Plomin R, et al. Mol Psychiatry. 2015 Feb;20(1):98-108. doi: 10.1038/mp.2014.105. Epub 2014 Sep 16. Mol Psychiatry. 2015. PMID: 25224258 Free PMC article. Review.
These five findings arose primarily from twin studies. They are being confirmed by the first new quantitative genetic technique in a century-Genome-wide Complex Trait Analysis (GCTA)-which estimates genetic influence using genome-wide gen …
These five findings arose primarily from twin studies. They are being confirmed by the first new quantitative genetic technique in a …
The complex genetic architecture of Alzheimer's disease: novel insights and future directions.
Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. Andrews SJ, et al. EBioMedicine. 2023 Apr;90:104511. doi: 10.1016/j.ebiom.2023.104511. Epub 2023 Mar 10. EBioMedicine. 2023. PMID: 36907103 Free PMC article. Review.
BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability estimates of 70% from twin studies. Progressively larger genom …
BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dement …
Estimating missing heritability for disease from genome-wide association studies.
Lee SH, Wray NR, Goddard ME, Visscher PM. Lee SH, et al. Am J Hum Genet. 2011 Mar 11;88(3):294-305. doi: 10.1016/j.ajhg.2011.02.002. Epub 2011 Mar 3. Am J Hum Genet. 2011. PMID: 21376301 Free PMC article.
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. ...Recently, we developed a method for quantitative traits that estimates the variation accounted for when fitting all SNPs simultaneously. H …
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. ...Recen …
Common SNPs explain a large proportion of the heritability for human height.
Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Yang J, et al. Nat Genet. 2010 Jul;42(7):565-9. doi: 10.1038/ng.608. Epub 2010 Jun 20. Nat Genet. 2010. PMID: 20562875 Free PMC article.
SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic variation of complex traits in human populations. Where is the remaining heritability? We estimated the proportion of variance for …
SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic vari …
Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing.
Lalami I, Abo C, Borghese B, Chapron C, Vaiman D. Lalami I, et al. Int J Mol Sci. 2021 Jul 7;22(14):7297. doi: 10.3390/ijms22147297. Int J Mol Sci. 2021. PMID: 34298916 Free PMC article. Review.
Despite the obvious genetic complexity of the disease, analysis of sibs has allowed heritability estimation of endometriosis at ~50%. From 2010, large Genome Wide Association Studies (GWAS), aimed at identifying the genes and loci …
Despite the obvious genetic complexity of the disease, analysis of sibs has allowed heritability estimation of endometr …
Heritability in inflammatory bowel disease: from the first twin study to genome-wide association studies.
Gordon H, Trier Moller F, Andersen V, Harbord M. Gordon H, et al. Inflamm Bowel Dis. 2015 Jun;21(6):1428-34. doi: 10.1097/MIB.0000000000000393. Inflamm Bowel Dis. 2015. PMID: 25895112 Free PMC article. Review.
Heritability estimates for Crohn's disease and ulcerative colitis from pooled twin studies are 0.75 and 0.67, respectively. However, this is at odds with the much lower heritability estimates from Genome-Wide Assoc …
Heritability estimates for Crohn's disease and ulcerative colitis from pooled twin studies are 0.75 and 0 …
Rare variant contribution to the heritability of coronary artery disease.
Rocheleau G, Clarke SL, Auguste G, Hasbani NR, Morrison AC, Heath AS, Bielak LF, Iyer KR, Young EP, Stitziel NO, Jun G, Laurie C, Broome JG, Khan AT, Arnett DK, Becker LC, Bis JC, Boerwinkle E, Bowden DW, Carson AP, Ellinor PT, Fornage M, Franceschini N, Freedman BI, Heard-Costa NL, Hou L, Chen YI, Kenny EE, Kooperberg C, Kral BG, Loos RJF, Lutz SM, Manson JE, Martin LW, Mitchell BD, Nassir R, Palmer ND, Post WS, Preuss MH, Psaty BM, Raffield LM, Regan EA, Rich SS, Smith JA, Taylor KD, Yanek LR, Young KA; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Hilliard AT, Tcheandjieu C, Peyser PA, Vasan RS, Rotter JI, Miller CL, Assimes TL, de Vries PS, Do R. Rocheleau G, et al. Nat Commun. 2024 Oct 9;15(1):8741. doi: 10.1038/s41467-024-52939-6. Nat Commun. 2024. PMID: 39384761 Free PMC article.
Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to WGS of 4949 cases and 17,494 controls of …
Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary …
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Büchel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, Guerreiro R, Hernandez DG, Brice A, Ylikotila P, Stefánsson H, Majamaa K, Morris HR, Williams N, Gasser T, Heutink P, Wood NW, Hardy J, Martinez M, Singleton AB, Nalls MA; International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2). Keller MF, et al. Hum Mol Genet. 2012 Nov 15;21(22):4996-5009. doi: 10.1093/hmg/dds335. Epub 2012 Aug 13. Hum Mol Genet. 2012. PMID: 22892372 Free PMC article.
Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with common traits remains unacc …
Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNP …
Epigenetics of Primary Biliary Cholangitis.
Li Y, Tang R, Ma X. Li Y, et al. Adv Exp Med Biol. 2020;1253:259-283. doi: 10.1007/978-981-15-3449-2_10. Adv Exp Med Biol. 2020. PMID: 32445099 Review.
Recently, genome-wide association studies (GWAS) have identified multiple genes influencing the susceptibility to PBC in HLA and non-HLA loci. However, it is estimated that the known risk variants merely account for no more than 20% of the he …
Recently, genome-wide association studies (GWAS) have identified multiple genes influencing the susceptibility t …
119 results