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Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models.
Morley TJ, Willimitis D, Ripperger M, Lee H, Han L, Zhou Y, Kang J, Davis LK, Smoller JW, Choi KW, Walsh CG, Ruderfer DM. Morley TJ, et al. medRxiv [Preprint]. 2023 Nov 1:2023.11.01.23297927. doi: 10.1101/2023.11.01.23297927. medRxiv. 2023. Update in: Genet Med. 2025 Apr;27(4):101353. doi: 10.1016/j.gim.2024.101353. PMID: 37961557 Free PMC article. Updated. Preprint.
Integrative Predictive Modeling of Metastasis in Melanoma Cancer Based on MicroRNA, mRNA, and DNA Methylation Data.
Kutlay A, Aydin Son Y. Kutlay A, et al. Front Mol Biosci. 2021 Sep 23;8:637355. doi: 10.3389/fmolb.2021.637355. eCollection 2021. Front Mol Biosci. 2021. PMID: 34631789 Free PMC article.
In the final integrated model, the addition of the methylation data resulted in a similar F-score of 92% but produced a stable model with low variance across multiple trials. Conclusion: Our results support the role of miRNA regulation in metastatic melanoma …
In the final integrated model, the addition of the methylation data resulted in a similar F-score of 92% but produced a stable …
Approaches to Incorporation of Preferences into Health Economic Models of Genomic Medicine: A Critical Interpretive Synthesis and Conceptual Framework.
Smith HS, Regier DA, Goranitis I, Bourke M, IJzerman MJ, Degeling K, Montgomery T, Phillips KA, Wordsworth S, Buchanan J, Marshall DA. Smith HS, et al. Appl Health Econ Health Policy. 2025 May;23(3):337-358. doi: 10.1007/s40258-025-00945-0. Epub 2025 Jan 20. Appl Health Econ Health Policy. 2025. PMID: 39832089