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Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease.
Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B, Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues JF, Berr C, Amouyel P, Bennett DA, van Duijn C, DeStefano AL, Launer LJ, Ikram MA, Crane PK, Lambert JC, Mayeux R, Seshadri S; International Genomics of Alzheimer’s Project. Chouraki V, et al. J Alzheimers Dis. 2016 Jun 18;53(3):921-32. doi: 10.3233/JAD-150749. J Alzheimers Dis. 2016. PMID: 27340842 Free PMC article.
Effective prevention of Alzheimer's disease (AD) requires the development of risk prediction tools permitting preclinical intervention. We constructed a genetic risk score (GRS) comprising common genetic variants asso …
Effective prevention of Alzheimer's disease (AD) requires the development of risk prediction tools permit …
The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms.
Limon-Sztencel A, Lipska-Ziętkiewicz BS, Chmara M, Wasag B, Bidzan L, Godlewska BR, Limon J. Limon-Sztencel A, et al. Alzheimers Res Ther. 2016 May 19;8(1):19. doi: 10.1186/s13195-016-0187-9. Alzheimers Res Ther. 2016. PMID: 27193889 Free PMC article.
BACKGROUND: Over the past two decades, the APOE gene and its polymorphisms have been among the most studied risk factors of Alzheimer disease (AD) development; yet, there are discrepancies between various studies regarding their impact. ...The 'prevent …
BACKGROUND: Over the past two decades, the APOE gene and its polymorphisms have been among the most studied risk factors of …
Development, Application, and Results from a Precision-medicine Platform that Personalizes Multi-modal Treatment Plans for Mild Alzheimer's Disease and At-risk Individuals.
Keine D, Walker JQ, Kennedy BK, Sabbagh MN. Keine D, et al. Curr Aging Sci. 2018;11(3):173-181. doi: 10.2174/1874609811666181019101430. Curr Aging Sci. 2018. PMID: 30338750 Free PMC article.
INTRODUCTION: Alzheimer's Disease (AD) is a progressive neurodegenerative condition in which individuals exhibit memory loss, dementia, and impaired metabolism. ...Here, we explored the efficacy of a multi-therapy approach based on the disease
INTRODUCTION: Alzheimer's Disease (AD) is a progressive neurodegenerative condition in which individuals exhibit memory …
Relation between plasma and brain lipids.
Wellington CL, Frikke-Schmidt R. Wellington CL, et al. Curr Opin Lipidol. 2016 Jun;27(3):225-32. doi: 10.1097/MOL.0000000000000291. Curr Opin Lipidol. 2016. PMID: 27149391 Review.
Whether plasma levels of apolipoprotein E, or any other apolipoprotein with possible central nervous system and/or blood-brain barrier functions (apolipoproteins J, A-I, A-II, A-IV, D, C-I, and C-III) may become accessible biomarker components that improve risk p
Whether plasma levels of apolipoprotein E, or any other apolipoprotein with possible central nervous system and/or blood-brain barrier funct …
Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging.
Mosconi L, Berti V, Glodzik L, Pupi A, De Santi S, de Leon MJ. Mosconi L, et al. J Alzheimers Dis. 2010;20(3):843-54. doi: 10.3233/JAD-2010-091504. J Alzheimers Dis. 2010. PMID: 20182025 Free PMC article. Review.
The development of prevention therapies for Alzheimer's disease (AD) would greatly benefit from biomarkers that are sensitive to subtle brain changes occurring in the preclinical stage of the disease. ...Many studies have shown that CMRglc reductions o …
The development of prevention therapies for Alzheimer's disease (AD) would greatly benefit from biomarkers that are sen …
Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits.
Nayor M, Short MI, Rasheed H, Lin H, Jonasson C, Yang Q, Hveem K, Felix JF, Morrison AC, Wild PS, Morley MP, Cappola TP, Benson MD; CHARGE-Heart Failure Working Group; CHARGE-EchoGen Consortium, Ngo D, Sinha S, Keyes MJ, Shen D, Wang TJ, Larson MG, Brumpton BM, Gerszten RE, Omland T, Vasan RS. Nayor M, et al. Circ Heart Fail. 2020 May;13(5):e006749. doi: 10.1161/CIRCHEARTFAILURE.119.006749. Epub 2020 May 15. Circ Heart Fail. 2020. PMID: 32408813
RESULTS: Seventeen proteins associated with echocardiographic traits in cross-sectional analyses (false discovery rate <0.10), and 8 of these proteins had pQTLs associated with echocardiographic traits in EchoGen (P<0.0007). In Cox models adjusted for clinical risk
RESULTS: Seventeen proteins associated with echocardiographic traits in cross-sectional analyses (false discovery rate <0.10), and 8 of t …
Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia.
Akinyemi RO, Mukaetova-Ladinska EB, Attems J, Ihara M, Kalaria RN. Akinyemi RO, et al. Curr Alzheimer Res. 2013 Jul;10(6):642-53. doi: 10.2174/15672050113109990037. Curr Alzheimer Res. 2013. PMID: 23627757 Review.
Vascular ageing involving arterial stiffness, endothelial changes and blood-brain barrier dysfunction affects neuronal survival by impairing several intracellular protective mechanisms leading to chronic hypoperfusion. Modifiable risk factors such as hypertension, d …
Vascular ageing involving arterial stiffness, endothelial changes and blood-brain barrier dysfunction affects neuronal survival by impairing …
Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model.
Begum AN, Yang F, Teng E, Hu S, Jones MR, Rosario ER, Beech W, Hudspeth B, Ubeda OJ, Cole GM, Frautschy SA. Begum AN, et al. J Alzheimers Dis. 2008 Dec;15(4):625-40. doi: 10.3233/jad-2008-15409. J Alzheimers Dis. 2008. PMID: 19096161 Free PMC article.
The rat amyloid-beta (Abeta) intracerebroventricular infusion can model aspects of Alzheimer's disease (AD) and has predicted efficacy of therapies such as ibuprofen and curcumin in transgenic mouse models. ...We focused on: 1) optimizing HDL-Abeta pre …
The rat amyloid-beta (Abeta) intracerebroventricular infusion can model aspects of Alzheimer's disease (AD) and has …
Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease.
de Leon MJ, Mosconi L, Blennow K, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Tsui W, Saint Louis LA, Sobanska L, Brys M, Li Y, Rich K, Rinne J, Rusinek H. de Leon MJ, et al. Ann N Y Acad Sci. 2007 Feb;1097:114-45. doi: 10.1196/annals.1379.012. Ann N Y Acad Sci. 2007. PMID: 17413016 Review.
It is widely believed that the path to early and effective treatment for Alzheimer's disease (AD) requires the development of early diagnostic markers that are both sensitive and specific. ...These measures provide secondary not primary evidence for AD. Conse …
It is widely believed that the path to early and effective treatment for Alzheimer's disease (AD) requires the developm …
Quantitative Longitudinal Predictions of Alzheimer's Disease by Multi-Modal Predictive Learning.
Prakash M, Abdelaziz M, Zhang L, Strange BA, Tohka J; Alzheimer’s Disease Neuroimaging Initiative. Prakash M, et al. J Alzheimers Dis. 2021;79(4):1533-1546. doi: 10.3233/JAD-200906. J Alzheimers Dis. 2021. PMID: 33459714
BACKGROUND: Quantitatively predicting the progression of Alzheimer's disease (AD) in an individual on a continuous scale, such as the Alzheimer's Disease Assessment Scale-cognitive (ADAS-cog) scores, is informative for a personaliz …
BACKGROUND: Quantitatively predicting the progression of Alzheimer's disease (AD) in an individual on a continuo …
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