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Fixed dose 4-factor prothrombin complex concentrate for the emergent reversal of warfarin: a retrospective analysis.
Astrup G, Sarangarm P, Burnett A. Astrup G, et al. J Thromb Thrombolysis. 2018 Feb;45(2):300-305. doi: 10.1007/s11239-017-1586-x. J Thromb Thrombolysis. 2018. PMID: 29164374
Published literature suggests that a fixed-dose 4-factor prothrombin complex concentrate (4FPCC) may be efficacious in managing warfarin-associated hemorrhage, however the ideal dose is still unclear. The purpose of t …
Published literature suggests that a fixed-dose 4-factor prothrombin complex concentrate (4 …
Prospective Evaluation of a Fixed-Dose 4-Factor Prothrombin Complex Concentrate Protocol for Urgent Vitamin K Antagonist Reversal.
Bitonti MT, Rumbarger RL, Absher RK, Curran LM. Bitonti MT, et al. J Emerg Med. 2020 Feb;58(2):324-329. doi: 10.1016/j.jemermed.2019.10.013. Epub 2019 Nov 29. J Emerg Med. 2020. PMID: 31787372
BACKGROUND: Four-factor prothrombin complex concentrate (4F-PCC) is the standard of care for reversal of vitamin K antagonists (VKAs). ...The prospective cohort was managed with a fixed-dose protocol. The fixed dose w …
BACKGROUND: Four-factor prothrombin complex concentrate (4F-PCC) is the standard of care for reversal of …
Evaluation of fixed dose 4-factor prothrombin complex concentrate for emergent warfarin reversal.
Klein L, Peters J, Miner J, Gorlin J. Klein L, et al. Am J Emerg Med. 2015 Sep;33(9):1213-8. doi: 10.1016/j.ajem.2015.05.017. Epub 2015 May 29. Am J Emerg Med. 2015. PMID: 26143315
OBJECTIVES: Four-factor prothrombin complex concentrates (4FPCCs) are emerging as the standard of care for emergent warfarin reversal due to their ability to rapidly and effectively achieve hemostasis. ...These findings suggest goo …
OBJECTIVES: Four-factor prothrombin complex concentrates (4FPCCs) are emerging as the standard of care for em
Emergent Warfarin Reversal With Fixed-Dose 4-Factor Prothrombin Complex Concentrate.
Jansma B, Montgomery J, Dietrich S, Mixon MA, Peksa GD, Faine B. Jansma B, et al. Ann Pharmacother. 2020 Nov;54(11):1090-1095. doi: 10.1177/1060028020920855. Epub 2020 May 16. Ann Pharmacother. 2020. PMID: 32418445
BACKGROUND: Four-factor prothrombin complex concentrate (4FPCC) is used for emergent warfarin reversal, but dosing remains controversial. ...Further data are needed, however, to determine which fixed-dose regimen prov …
BACKGROUND: Four-factor prothrombin complex concentrate (4FPCC) is used for emergent warfarin r
A Retrospective Comparison of 3-Factor Prothrombin Complex Concentrate Products for Warfarin Reversal.
Jones GM, Cave B, Cook R. Jones GM, et al. Neurohospitalist. 2020 Jul;10(3):201-207. doi: 10.1177/1941874420905755. Epub 2020 Mar 4. Neurohospitalist. 2020. PMID: 32549944
BACKGROUND AND PURPOSE: Current guidelines suggest that 3-factor prothrombin complex concentrate is a possible alternative to 4-factor products for the emergent reversal of bleeding secondary to warfarin. While multip …
BACKGROUND AND PURPOSE: Current guidelines suggest that 3-factor prothrombin complex concentrate is a possible a …
Comparison of 3 Different Prothrombin Complex Concentrate Regimens for Emergent Warfarin Reversal: PCCWaR Study.
Dietrich SK, Rowe S, Cocchio CA, Harmon AJ, Nerenberg SF, Blankenship PS. Dietrich SK, et al. Ann Pharmacother. 2020 Dec 11:1060028020978568. doi: 10.1177/1060028020978568. Online ahead of print. Ann Pharmacother. 2020. PMID: 33305592
BACKGROUND: The ideal dose and specific prothrombin complex concentrate (PCC) for warfarin reversal is unknown. OBJECTIVE: To evaluate the reduction in international normalized ratio (INR) of 3 different PCC dosing regimens: fix
BACKGROUND: The ideal dose and specific prothrombin complex concentrate (PCC) for warfarin reversal
Evaluation of a Fixed-Dose Regimen of 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal.
McMahon C, Halfpap J, Zhao Q, Bienvenida A, Rose AE. McMahon C, et al. Ann Pharmacother. 2021 Feb 1:1060028021992142. doi: 10.1177/1060028021992142. Online ahead of print. Ann Pharmacother. 2021. PMID: 33522256
BACKGROUND: Fixed-dose (FD) regimens of 4-factor prothrombin complex concentrate (4F-PCC) may be effective for the emergent reversal of warfarin; however, the optimal dosing is unknown. ...In the INR 6 non-CNS …
BACKGROUND: Fixed-dose (FD) regimens of 4-factor prothrombin complex concentrate (4F-PCC) m …