Evans DC - Search Results

1

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

Leclercq L, Cuyckens F, Mannens GS, de Vries R, Timmerman P, Evans DC. Leclercq L, et al. Among authors: evans dc. Chem Res Toxicol. 2009 Feb;22(2):280-93. doi: 10.1021/tx800432c. Chem Res Toxicol. 2009. PMID: 19183054 Review.

2

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

Mamidi RN, Cuyckens F, Chen J, Scheers E, Kalamaridis D, Lin R, Silva J, Sha S, Evans DC, Kelley MF, Devineni D, Johnson MD, Lim HK. Mamidi RN, et al. Among authors: evans dc. Drug Metab Dispos. 2014 May;42(5):903-16. doi: 10.1124/dmd.113.056440. Epub 2014 Feb 25. Drug Metab Dispos. 2014. PMID: 24568888 Clinical Trial.

3

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.

Mamidi RNVS, Dallas S, Sensenhauser C, Lim HK, Scheers E, Verboven P, Cuyckens F, Leclercq L, Evans DC, Kelley MF, Johnson MD, Snoeys J. Mamidi RNVS, et al. Among authors: evans dc. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. doi: 10.1111/bcp.13186. Epub 2016 Dec 20. Br J Clin Pharmacol. 2017. PMID: 27862160 Free PMC article.

4

Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.

Lim HK, Chen J, Sensenhauser C, Cook K, Preston R, Thomas T, Shook B, Jackson PF, Rassnick S, Rhodes K, Gopaul V, Salter R, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Chem Res Toxicol. 2011 Jul 18;24(7):1012-30. doi: 10.1021/tx1004437. Epub 2011 Jun 28. Chem Res Toxicol. 2011. PMID: 21667953

5

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.

Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA. Evans DC, et al. Chem Res Toxicol. 2004 Jan;17(1):3-16. doi: 10.1021/tx034170b. Chem Res Toxicol. 2004. PMID: 14727914 Review.

6

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.

Zhang Z, Chen Q, Li Y, Doss GA, Dean BJ, Ngui JS, Silva Elipe M, Kim S, Wu JY, Dininno F, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Zhang Z, et al. Among authors: evans dc. Chem Res Toxicol. 2005 Apr;18(4):675-85. doi: 10.1021/tx0496789. Chem Res Toxicol. 2005. PMID: 15833027

7

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.

Chen Q, Ngui JS, Doss GA, Wang RW, Cai X, DiNinno FP, Blizzard TA, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: evans dc. Chem Res Toxicol. 2002 Jul;15(7):907-14. doi: 10.1021/tx0200109. Chem Res Toxicol. 2002. PMID: 12119000

8

Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.

Doss GA, Miller RR, Zhang Z, Teffera Y, Nargund RP, Palucki B, Park MK, Tang YS, Evans DC, Baillie TA, Stearns RA. Doss GA, et al. Among authors: evans dc. Chem Res Toxicol. 2005 Feb;18(2):271-6. doi: 10.1021/tx049711r. Chem Res Toxicol. 2005. PMID: 15720132

9

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.

Lim HK, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Rapid Commun Mass Spectrom. 2008 Apr;22(8):1295-311. doi: 10.1002/rcm.3504. Rapid Commun Mass Spectrom. 2008. PMID: 18383206

10

Minimizing the potential for metabolic activation as an integral part of drug design.

Evans DC, Baillie TA. Evans DC, et al. Curr Opin Drug Discov Devel. 2005 Jan;8(1):44-50. Curr Opin Drug Discov Devel. 2005. PMID: 15679171 Review.

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