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Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy.
Merkel R, Nassoy P, Leung A, Ritchie K, Evans E. Merkel R, et al. Among authors: evans e. Nature. 1999 Jan 7;397(6714):50-3. doi: 10.1038/16219. Nature. 1999. PMID: 9892352
Probing the relation between force--lifetime--and chemistry in single molecular bonds.
Evans E. Evans E. Annu Rev Biophys Biomol Struct. 2001;30:105-28. doi: 10.1146/annurev.biophys.30.1.105. Annu Rev Biophys Biomol Struct. 2001. PMID: 11340054 Review.
Synchrony of cell spreading and contraction force as phagocytes engulf large pathogens.
Evans E, Leung A, Zhelev D. Evans E, et al. J Cell Biol. 1993 Sep;122(6):1295-300. doi: 10.1083/jcb.122.6.1295. J Cell Biol. 1993. PMID: 8376464 Free PMC article.
The surprising feature of the phagocyte response was that engulfment and cell body contraction occurred in a serial sequence: i.e., the phagocyte spread rapidly over the particle at a steady rate with no detectable cell body contraction; when spreading stopped, contraction …
The surprising feature of the phagocyte response was that engulfment and cell body contraction occurred in a serial sequence: i.e., t …
Strength of a weak bond connecting flexible polymer chains.
Evans E, Ritchie K. Evans E, et al. Biophys J. 1999 May;76(5):2439-47. doi: 10.1016/S0006-3495(99)77399-6. Biophys J. 1999. PMID: 10233061 Free PMC article.
Bond dissociation under steadily rising force occurs most frequently at a time governed by the rate of loading (Evans and Ritchie, 1997 Biophys. ...
Bond dissociation under steadily rising force occurs most frequently at a time governed by the rate of loading (Evans and Ritchie, 19 …
Dynamic strength of molecular adhesion bonds.
Evans E, Ritchie K. Evans E, et al. Biophys J. 1997 Apr;72(4):1541-55. doi: 10.1016/S0006-3495(97)78802-7. Biophys J. 1997. PMID: 9083660 Free PMC article.
By definition, bond strength is the force that produces the most frequent failure in repeated tests of breakage, i.e., the peak in the distribution of rupture forces. ...
By definition, bond strength is the force that produces the most frequent failure in repeated tests of breakage, i.e., the peak in th …
Sensitive force technique to probe molecular adhesion and structural linkages at biological interfaces.
Evans E, Ritchie K, Merkel R. Evans E, et al. Biophys J. 1995 Jun;68(6):2580-7. doi: 10.1016/S0006-3495(95)80441-8. Biophys J. 1995. PMID: 7647261 Free PMC article.
Detachment of agglutinin-bonded red blood cells. I. Forces to rupture molecular-point attachments.
Evans E, Berk D, Leung A. Evans E, et al. Biophys J. 1991 Apr;59(4):838-48. doi: 10.1016/S0006-3495(91)82296-2. Biophys J. 1991. PMID: 2065188 Free PMC article.
The surprising outcome of the measurements and analysis was that the forces deduced for short-time failure of 1-2 molecular attachments were nearly the same for all of the agglutinin, i.e., 1-2 x 10(-6) dyn. ...
The surprising outcome of the measurements and analysis was that the forces deduced for short-time failure of 1-2 molecular attachments were …
Chemically distinct transition states govern rapid dissociation of single L-selectin bonds under force.
Evans E, Leung A, Hammer D, Simon S. Evans E, et al. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3784-9. doi: 10.1073/pnas.061324998. Epub 2001 Mar 13. Proc Natl Acad Sci U S A. 2001. PMID: 11274395 Free PMC article.
The cell surface carbohydrate ligands are glycosylated proteins like the mucin P-selectin glycoprotein ligand-1 (PSGL-1), which bind ubiquitously to the family of E-, P-, and L-selectin proteins in membranes of leukocytes and endothelium. ...
The cell surface carbohydrate ligands are glycosylated proteins like the mucin P-selectin glycoprotein ligand-1 (PSGL-1), which bind ubiquit …
Looking inside molecular bonds at biological interfaces with dynamic force spectroscopy.
Evans E. Evans E. Biophys Chem. 1999 Dec 13;82(2-3):83-97. doi: 10.1016/s0301-4622(99)00108-8. Biophys Chem. 1999. PMID: 10631793
Plotted as a function of log(e) (loading rate), the dynamic spectrum of bond strength provides an image of the prominent barriers traversed in the energy landscape along the unbinding pathway, which establishes a direct link between measurements of bond force and molecular …
Plotted as a function of log(e) (loading rate), the dynamic spectrum of bond strength provides an image of the prominent barriers tra …
Energy landscapes of biomolecular adhesion and receptor anchoring at interfaces explored with dynamic force spectroscopy.
Evans E. Evans E. Faraday Discuss. 1998;(111):1-16. doi: 10.1039/a809884k. Faraday Discuss. 1998. PMID: 10822596
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