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Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride.
Premkumar A, Wilson L, Ewart GD, Gage PW. Premkumar A, et al. Among authors: ewart gd. FEBS Lett. 2004 Jan 16;557(1-3):99-103. doi: 10.1016/s0014-5793(03)01453-4. FEBS Lett. 2004. PMID: 14741348 Free article.
Validation of coronavirus E proteins ion channels as targets for antiviral drugs.
Wilson L, Gage P, Ewart G. Wilson L, et al. Among authors: ewart g. Adv Exp Med Biol. 2006;581:573-8. doi: 10.1007/978-0-387-33012-9_104. Adv Exp Med Biol. 2006. PMID: 17037600 Free PMC article. No abstract available.
SARS coronavirus E protein forms cation-selective ion channels.
Wilson L, McKinlay C, Gage P, Ewart G. Wilson L, et al. Among authors: ewart g. Virology. 2004 Dec 5;330(1):322-31. doi: 10.1016/j.virol.2004.09.033. Virology. 2004. PMID: 15527857 Free PMC article.
Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication.
Wilson L, Gage P, Ewart G. Wilson L, et al. Among authors: ewart g. Virology. 2006 Sep 30;353(2):294-306. doi: 10.1016/j.virol.2006.05.028. Epub 2006 Jul 3. Virology. 2006. PMID: 16815524 Free PMC article.
., Ewart, G., 2004. SARS coronavirus E protein forms cation-selective ion channels. Virology 330(1), 322-331). We now report that three other E proteins also form cation-selective ion channels. ...
., Ewart, G., 2004. SARS coronavirus E protein forms cation-selective ion channels. Virology 330(1), 322-331). We now report that thr …
Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu.
Ewart GD, Mills K, Cox GB, Gage PW. Ewart GD, et al. Eur Biophys J. 2002 Mar;31(1):26-35. doi: 10.1007/s002490100177. Eur Biophys J. 2002. PMID: 12046895
Alphavirus 6K proteins form ion channels.
Melton JV, Ewart GD, Weir RC, Board PG, Lee E, Gage PW. Melton JV, et al. Among authors: ewart gd. J Biol Chem. 2002 Dec 6;277(49):46923-31. doi: 10.1074/jbc.M207847200. Epub 2002 Sep 12. J Biol Chem. 2002. PMID: 12228229 Free article.
Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages.
Ewart GD, Nasr N, Naif H, Cox GB, Cunningham AL, Gage PW. Ewart GD, et al. Antimicrob Agents Chemother. 2004 Jun;48(6):2325-30. doi: 10.1128/AAC.48.6.2325-2330.2004. Antimicrob Agents Chemother. 2004. PMID: 15155246 Free PMC article.
A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues.
Luscombe CA, Huang Z, Murray MG, Miller M, Wilkinson J, Ewart GD. Luscombe CA, et al. Among authors: ewart gd. Antiviral Res. 2010 May;86(2):144-53. doi: 10.1016/j.antiviral.2010.02.312. Epub 2010 Feb 13. Antiviral Res. 2010. PMID: 20156486
Ion channels formed by NB, an influenza B virus protein.
Sunstrom NA, Premkumar LS, Premkumar A, Ewart G, Cox GB, Gage PW. Sunstrom NA, et al. Among authors: ewart g. J Membr Biol. 1996 Mar;150(2):127-32. doi: 10.1007/s002329900037. J Membr Biol. 1996. PMID: 8661776
A 2a/1b full-length p7 inter-genotypic chimeric genome of hepatitis C virus is infectious in vitro.
Haqshenas G, Dong X, Ewart G, Bowden S, Gowans EJ. Haqshenas G, et al. Among authors: ewart g. Virology. 2007 Mar 30;360(1):17-26. doi: 10.1016/j.virol.2006.10.014. Epub 2006 Nov 9. Virology. 2007. PMID: 17097709 Free PMC article.
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