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Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy.
Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU, Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Müller WC, Bonn S, Bechmann I, Nave KA, Stassart RM, Sereda MW. Fledrich R, et al. Among authors: ewers d. Nat Commun. 2018 Aug 2;9(1):3025. doi: 10.1038/s41467-018-05420-0. Nat Commun. 2018. PMID: 30072689 Free PMC article.
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot-Marie-Tooth disease type 1A (CMT1A) rats.
Prukop T, Wernick S, Boussicault L, Ewers D, Jäger K, Adam J, Winter L, Quintes S, Linhoff L, Barrantes-Freer A, Bartl M, Czesnik D, Zschüntzsch J, Schmidt J, Primas G, Laffaire J, Rinaudo P, Brureau A, Nabirotchkin S, Schwab MH, Nave KA, Hajj R, Cohen D, Sereda MW. Prukop T, et al. Among authors: ewers d. J Neurosci Res. 2020 Oct;98(10):1933-1952. doi: 10.1002/jnr.24679. Epub 2020 Jun 26. J Neurosci Res. 2020. PMID: 32588471
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G. Berghoff SA, et al. Among authors: ewers d. Nat Neurosci. 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. Nat Neurosci. 2021. PMID: 33349711 Free PMC article.
Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.
Sundaram VK, Schütza V, Schröter NH, Backhaus A, Bilsing A, Joneck L, Seelbach A, Mutschler C, Gomez-Sanchez JA, Schäffner E, Sánchez EE, Akkermann D, Paul C, Schwagarus N, Müller S, Odle A, Childs G, Ewers D, Kungl T, Sitte M, Salinas G, Sereda MW, Nave KA, Schwab MH, Ost M, Arthur-Farraj P, Stassart RM, Fledrich R. Sundaram VK, et al. Among authors: ewers d. Cell Metab. 2023 Dec 5;35(12):2136-2152.e9. doi: 10.1016/j.cmet.2023.10.017. Epub 2023 Nov 20. Cell Metab. 2023. PMID: 37989315 Free PMC article.
Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases.
Krauter D, Stausberg D, Hartmann TJ, Volkmann S, Kungl T, Rasche DA, Saher G, Fledrich R, Stassart RM, Nave KA, Goebbels S, Ewers D, Sereda MW. Krauter D, et al. Among authors: ewers d. EMBO Mol Med. 2024 Mar;16(3):616-640. doi: 10.1038/s44321-023-00019-5. Epub 2024 Feb 21. EMBO Mol Med. 2024. PMID: 38383802 Free PMC article.
Allosteric gate modulation confers K+ coupling in glutamate transporters.
Kortzak D, Alleva C, Weyand I, Ewers D, Zimmermann MI, Franzen A, Machtens JP, Fahlke C. Kortzak D, et al. Among authors: ewers d. EMBO J. 2019 Oct 1;38(19):e101468. doi: 10.15252/embj.2019101468. Epub 2019 Sep 10. EMBO J. 2019. PMID: 31506973 Free PMC article.
Mechanisms of anion conduction by coupled glutamate transporters.
Machtens JP, Kortzak D, Lansche C, Leinenweber A, Kilian P, Begemann B, Zachariae U, Ewers D, de Groot BL, Briones R, Fahlke C. Machtens JP, et al. Among authors: ewers d. Cell. 2015 Jan 29;160(3):542-53. doi: 10.1016/j.cell.2014.12.035. Cell. 2015. PMID: 25635461 Free article.
18 results