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Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.
Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, Johnson RW. Godbout JP, et al. FASEB J. 2005 Aug;19(10):1329-31. doi: 10.1096/fj.05-3776fje. Epub 2005 May 26. FASEB J. 2005. PMID: 15919760
., delirium) is common in elderly emergency department patients and frequently results from infections that are unrelated to the central nervous system. Since activation of the peripheral innate immune system induces brain microglia to pr …
., delirium) is common in elderly emergency department patients and frequently results from infections that are unrelated to the central ner …
Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1beta promoter DNA methylation in microglia.
Matt SM, Lawson MA, Johnson RW. Matt SM, et al. Neurobiol Aging. 2016 Nov;47:1-9. doi: 10.1016/j.neurobiolaging.2016.07.006. Epub 2016 Jul 15. Neurobiol Aging. 2016. PMID: 27500965 Free PMC article.
In aged mice, peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) causes exaggerated neuroinflammation and prolonged sickness behavior due in part to microglial dysfunction. ...We f …
In aged mice, peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) cau …
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