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Examining the Impact of Polygenic Risk Information in Primary Care.
Pacyna JE, Ennis JS, Kullo IJ, Sharp RR. Pacyna JE, et al. J Prim Care Community Health. 2023 Jan-Dec;14:21501319231151766. doi: 10.1177/21501319231151766. J Prim Care Community Health. 2023. PMID: 36718804 Free PMC article.
BACKGROUND: Polygenic risk testing examines variation across multiple genes to estimate a risk score for a particular disease, including risk scores for many common, chronic health conditions. Although polygenic risk info
BACKGROUND: Polygenic risk testing examines variation across multiple genes to estimate a risk score for a parti …
Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations.
Capalbo A, de Wert G, Mertes H, Klausner L, Coonen E, Spinella F, Van de Velde H, Viville S, Sermon K, Vermeulen N, Lencz T, Carmi S. Capalbo A, et al. Hum Reprod Update. 2024 May 28:dmae012. doi: 10.1093/humupd/dmae012. Online ahead of print. Hum Reprod Update. 2024. PMID: 38805697
OUTCOMES: The main theoretical benefit of PES is a reduction in lifetime polygenic disease risk for children born after screening. The magnitude of the risk reduction has been predicted based on statistical modelling, simulations, and sibling pair analyses. . …
OUTCOMES: The main theoretical benefit of PES is a reduction in lifetime polygenic disease risk for children born after screen …