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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 3
1963 1
1968 1
1970 2
1973 1
1977 1
1980 2
1982 2
1983 3
1985 1
1986 1
1988 6
1990 6
1991 4
1992 3
1993 4
1994 13
1995 14
1996 17
1997 14
1998 15
1999 10
2000 19
2001 17
2002 22
2003 32
2004 40
2005 43
2006 40
2007 48
2008 63
2009 58
2010 50
2011 76
2012 76
2013 91
2014 91
2015 106
2016 94
2017 101
2018 106
2019 97
2020 90
2021 83
2022 102
2023 87
2024 54

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1,622 results

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Page 1
In Vitro Human Haematopoietic Stem Cell Expansion and Differentiation.
Bozhilov YK, Hsu I, Brown EJ, Wilkinson AC. Bozhilov YK, et al. Cells. 2023 Mar 14;12(6):896. doi: 10.3390/cells12060896. Cells. 2023. PMID: 36980237 Free PMC article. Review.
This process of haematopoiesis is tightly regulated in vivo and primarily takes place in the bone marrow. Over the years, a range of in vitro culture systems have been developed, either to expand haematopoietic stem and progenitor cells or to differentiate them into the va …
This process of haematopoiesis is tightly regulated in vivo and primarily takes place in the bone marrow. Over the years, a range of …
Peripheral T cell expansion predicts tumour infiltration and clinical response.
Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O'Gorman WE, Au-Yeung A, Takahashi C, Goldstein LD, Poon C, Keerthivasan S, de Almeida Nagata DE, Du X, Lee HM, Banta KL, Mariathasan S, Das Thakur M, Huseni MA, Ballinger M, Estay I, Caplazi P, Modrusan Z, Delamarre L, Mellman I, Bourgon R, Grogan JL. Wu TD, et al. Nature. 2020 Mar;579(7798):274-278. doi: 10.1038/s41586-020-2056-8. Epub 2020 Feb 26. Nature. 2020. PMID: 32103181
We find clear evidence of clonotypic expansion of effector-like T cells not only within the tumour but also in normal adjacent tissue. Patients with gene signatures of such clonotypic expansion respond best to anti-PDL1 therapy. ...Analyses of our data together with severa …
We find clear evidence of clonotypic expansion of effector-like T cells not only within the tumour but also in normal adjacent tissue. Patie …
B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing.
Frede A, Czarnewski P, Monasterio G, Tripathi KP, Bejarano DA, Ramirez Flores RO, Sorini C, Larsson L, Luo X, Geerlings L, Novella-Rausell C, Zagami C, Kuiper R, Morales RA, Castillo F, Hunt M, Mariano LL, Hu YOO, Engblom C, Lennon-Duménil AM, Mittenzwei R, Westendorf AM, Hövelmeyer N, Lundeberg J, Saez-Rodriguez J, Schlitzer A, Das S, Villablanca EJ. Frede A, et al. Immunity. 2022 Dec 13;55(12):2336-2351.e12. doi: 10.1016/j.immuni.2022.11.002. Epub 2022 Dec 2. Immunity. 2022. PMID: 36462502 Free article.
B cell depletion accelerated recovery upon injury, decreased epithelial ulceration, and enhanced gene expression programs associated with tissue remodeling. scRNA-seq from the epithelial and stromal compartments combined with spatial transcriptomics and multiplex im …
B cell depletion accelerated recovery upon injury, decreased epithelial ulceration, and enhanced gene expression programs asso …
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, Mack TM, Luna SE, Prothro KP, Mitchell SR, Laurie CA, Broome JG, Taylor KD, Guo X, Sinner MF, von Falkenhausen AS, Kääb S, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Hou L, Lloyd-Jones DM, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Palmer ND, Freedman BI, Bowden DW, Cho MH, DeMeo DL, Vasan RS, Yanek LR, Becker LC, Kardia SLR, Peyser PA, He J, Rienstra M, Van der Harst P, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Cutler MJ, Knight S, Muhlestein JB, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Tracy RP, Konkle BA, Johnsen JM, Wheeler MM, Smith JG, Melander O, Nilsson PM, Custer BS, Duggirala R, Curran JE, Blangero J, McGarvey S, Williams LK, Xiao S, Yang M, Gu CC, Chen YI, Lee WJ, Marcus GM, Kane JP, Pullinger CR, Shoemaker MB, Darbar D, Roden DM, Albert C, Kooperberg C, Zhou Y, Manson JE, Desai P, Johnson AD, Mathias RA; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Blackwell TW, Abecasis GR, Smith AV, Kang HM, Satpathy A… See abstract for full author list ➔ Weinstock JS, et al. Nature. 2023 Apr;616(7958):755-763. doi: 10.1038/s41586-023-05806-1. Epub 2023 Apr 12. Nature. 2023. PMID: 37046083 Free PMC article.
TCL1A was not expressed in normal or DNMT3A-mutated HSCs, but the introduction of mutations in TET2 or ASXL1 led to the expression of TCL1A protein and the expansion of HSCs in vitro. ...Our results indicate that the fitness advantage of several commonly mutated dri …
TCL1A was not expressed in normal or DNMT3A-mutated HSCs, but the introduction of mutations in TET2 or ASXL1 led to the expression
Injury prevents Ras mutant cell expansion in mosaic skin.
Gallini S, Annusver K, Rahman NT, Gonzalez DG, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi KC, Kasper M, Greco V. Gallini S, et al. Nature. 2023 Jul;619(7968):167-175. doi: 10.1038/s41586-023-06198-y. Epub 2023 Jun 21. Nature. 2023. PMID: 37344586 Free PMC article.
Mechanistically, we show that, unlike Hras(G12V/+) cells, wild-type cells respond to autocrine and paracrine secretion of EGFR ligands, and this differential activation of the EGFR pathway explains the competitive switch during injury repair. ...
Mechanistically, we show that, unlike Hras(G12V/+) cells, wild-type cells respond to autocrine and paracrine secretion of EGFR ligands, and …
TET2 guards against unchecked BATF3-induced CAR T cell expansion.
Jain N, Zhao Z, Feucht J, Koche R, Iyer A, Dobrin A, Mansilla-Soto J, Yang J, Zhan Y, Lopez M, Gunset G, Sadelain M. Jain N, et al. Nature. 2023 Mar;615(7951):315-322. doi: 10.1038/s41586-022-05692-z. Epub 2023 Feb 8. Nature. 2023. PMID: 36755094 Free PMC article.
As T cell differentiation and functional states are associated with distinct epigenetic profiles(6,7), we hypothesized that epigenetic programming may provide a means to improve CAR T cell performance. Targeting the gene that encodes the epigenetic regulator ten-eleven tra …
As T cell differentiation and functional states are associated with distinct epigenetic profiles(6,7), we hypothesized that epigenetic progr …
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, Verway MJ, Raissi TC, Tsui H, Boukhaled G, Henriques da Costa S, Frezza C, Krawczyk CM, Friedman A, Manfredi M, Richer MJ, Hess C, Jones RG. Ma EH, et al. Cell Metab. 2017 Feb 7;25(2):345-357. doi: 10.1016/j.cmet.2016.12.011. Epub 2017 Jan 19. Cell Metab. 2017. PMID: 28111214 Free article.
Here we report a critical role for the non-essential amino acid serine in effector T cell responses. Upon activation, T cells upregulate enzymes of the serine, glycine, one-carbon (SGOC) metabolic network, and rapidly increase processing of serine into one-carbon me …
Here we report a critical role for the non-essential amino acid serine in effector T cell responses. Upon activation, T cells upregul …
Natural Killer Cell Expansion and Cytotoxicity Differ Depending on the Culture Medium Used.
Koh SK, Park J, Kim SE, Lim Y, Phan MT, Kim J, Hwang I, Ahn YO, Shin S, Doh J, Cho D. Koh SK, et al. Ann Lab Med. 2022 Nov 1;42(6):638-649. doi: 10.3343/alm.2022.42.6.638. Ann Lab Med. 2022. PMID: 35765872 Free PMC article.
The effects of the culture media and human serum supplementation on NK cell expansion and cytotoxicity were evaluated by analyzing the expansion rate, activating and inhibitory receptor levels, and the cytotoxicity of the UCB NK cells. ...
The effects of the culture media and human serum supplementation on NK cell expansion and cytotoxicity were evaluated by analyzing the expan …
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion.
Guilbaud E, Barouillet T, Ilie M, Borowczyk C, Ivanov S, Sarrazy V, Vaillant N, Ayrault M, Castiglione A, Rignol G, Brest P, Bazioti V, Zaitsev K, Lebrigand K, Dussaud S, Magnone V, Bertolotto C, Marchetti S, Irondelle M, Goldberg I, Huby T, Westerterp M, Gautier EL, Mari B, Barbry P, Hofman P, Yvan-Charvet L. Guilbaud E, et al. Cell Stem Cell. 2023 Jun 1;30(6):800-817.e9. doi: 10.1016/j.stem.2023.05.005. Cell Stem Cell. 2023. PMID: 37267915 Free article.
A peptide hormone and its receptor protein kinase regulate plant cell expansion.
Haruta M, Sabat G, Stecker K, Minkoff BB, Sussman MR. Haruta M, et al. Science. 2014 Jan 24;343(6169):408-11. doi: 10.1126/science.1244454. Science. 2014. PMID: 24458638 Free PMC article.
We found that a secreted peptide, RALF (rapid alkalinization factor), suppresses cell elongation of the primary root by activating the cell surface receptor FERONIA in Arabidopsis thaliana. ...
We found that a secreted peptide, RALF (rapid alkalinization factor), suppresses cell elongation of the primary root by activating th …
1,622 results