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A new MAFia in cancer.
Eychène A, Rocques N, Pouponnot C. Eychène A, et al. Nat Rev Cancer. 2008 Sep;8(9):683-93. doi: 10.1038/nrc2460. Nat Rev Cancer. 2008. PMID: 19143053 Review.
NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.
Garancher A, Lin CY, Morabito M, Richer W, Rocques N, Larcher M, Bihannic L, Smith K, Miquel C, Leboucher S, Herath NI, Dupuy F, Varlet P, Haberler C, Walczak C, El Tayara N, Volk A, Puget S, Doz F, Delattre O, Druillennec S, Ayrault O, Wechsler-Reya RJ, Eychène A, Bourdeaut F, Northcott PA, Pouponnot C. Garancher A, et al. Among authors: eychene a. Cancer Cell. 2018 Mar 12;33(3):435-449.e6. doi: 10.1016/j.ccell.2018.02.006. Cancer Cell. 2018. PMID: 29533784 Free PMC article.
Alternative splicing in oncogenic kinases: from physiological functions to cancer.
Druillennec S, Dorard C, Eychène A. Druillennec S, et al. Among authors: eychene a. J Nucleic Acids. 2012;2012:639062. doi: 10.1155/2012/639062. Epub 2011 Oct 5. J Nucleic Acids. 2012. PMID: 22007291 Free PMC article.
RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma.
Dorard C, Estrada C, Barbotin C, Larcher M, Garancher A, Leloup J, Beermann F, Baccarini M, Pouponnot C, Larue L, Eychène A, Druillennec S. Dorard C, et al. Among authors: eychene a. Nat Commun. 2017 May 12;8:15262. doi: 10.1038/ncomms15262. Nat Commun. 2017. PMID: 28497782 Free PMC article.
PFKFB4 controls embryonic patterning via Akt signalling independently of glycolysis.
Pegoraro C, Figueiredo AL, Maczkowiak F, Pouponnot C, Eychène A, Monsoro-Burq AH. Pegoraro C, et al. Among authors: eychene a. Nat Commun. 2015 Jan 20;6:5953. doi: 10.1038/ncomms6953. Nat Commun. 2015. PMID: 25601028
Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.
Cerezo M, Guemiri R, Druillennec S, Girault I, Malka-Mahieu H, Shen S, Allard D, Martineau S, Welsch C, Agoussi S, Estrada C, Adam J, Libenciuc C, Routier E, Roy S, Désaubry L, Eggermont AM, Sonenberg N, Scoazec JY, Eychène A, Vagner S, Robert C. Cerezo M, et al. Among authors: eychene a. Nat Med. 2018 Dec;24(12):1877-1886. doi: 10.1038/s41591-018-0217-1. Epub 2018 Oct 29. Nat Med. 2018. PMID: 30374200
BRAF as a melanoma susceptibility candidate gene?
Laud K, Kannengiesser C, Avril MF, Chompret A, Stoppa-Lyonnet D, Desjardins L, Eychene A, Demenais F, Lenoir GM, Bressac-de Paillerets B; French Herediatary Melanoma Study Group. Laud K, et al. Cancer Res. 2003 Jun 15;63(12):3061-5. Cancer Res. 2003. PMID: 12810628
A high frequency of activating BRAF somatic mutations have been identified recently in malignant melanoma and nevi indicating that BRAF activation could be an early and critical step in the initiation of melanocytic neoplasia. ...Our data suggest that BRAF is unlikely to b
A high frequency of activating BRAF somatic mutations have been identified recently in malignant melanoma and nevi indicating that BR
MafA transcription factor identifies the early ret-expressing sensory neurons.
Lecoin L, Rocques N, El-Yakoubi W, Ben Achour S, Larcher M, Pouponnot C, Eychène A. Lecoin L, et al. Dev Neurobiol. 2010 Jun;70(7):485-97. doi: 10.1002/dneu.20790. Dev Neurobiol. 2010. PMID: 20213756
Using knockout mice, we identified the bZIP transcription factor MafA as the first specific marker of a subpopulation of "early c-ret" positive neurons characterized by medium-to-large diameters. ...
Using knockout mice, we identified the bZIP transcription factor MafA as the first specific marker of a subpopulation of "early c-ret …
GSK-3-mediated phosphorylation enhances Maf-transforming activity.
Rocques N, Abou Zeid N, Sii-Felice K, Lecoin L, Felder-Schmittbuhl MP, Eychène A, Pouponnot C. Rocques N, et al. Mol Cell. 2007 Nov 30;28(4):584-97. doi: 10.1016/j.molcel.2007.11.009. Mol Cell. 2007. PMID: 18042454
Here, we show that Maf-transforming activity is controlled by GSK-3-dependent phosphorylation and that phosphorylation by GSK-3 can increase the oncogenic activity of a protein. Using microarray analysis, we identify a gene-expression subprogram regulated by GSK-3-m …
Here, we show that Maf-transforming activity is controlled by GSK-3-dependent phosphorylation and that phosphorylation by GSK-3 can increase …
Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms.
Hmitou I, Druillennec S, Valluet A, Peyssonnaux C, Eychène A. Hmitou I, et al. Mol Cell Biol. 2007 Jan;27(1):31-43. doi: 10.1128/MCB.01265-06. Epub 2006 Oct 30. Mol Cell Biol. 2007. PMID: 17074813 Free PMC article.
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