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160 results

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Page 1
FBXO11 regulates bone development.
Huang H, Lu J, Aukhil I, Yu C, Bhut B, Marchesan J, Pirih F, Chang J. Huang H, et al. Bone. 2023 May;170:116709. doi: 10.1016/j.bone.2023.116709. Epub 2023 Mar 1. Bone. 2023. PMID: 36863499 Free PMC article.
The role of FBXO11 in bone development is unexplored. In this study, we reported a novel mechanism of how bone development is regulated by FBXO11. FBXO11 gene knockdown by lentiviral transduction in mouse pre-osteoblast MC3T3-E1 cells leads to reduced osteoge …
The role of FBXO11 in bone development is unexplored. In this study, we reported a novel mechanism of how bone development is regulat …
De novo variants in FBXO11 cause a syndromic form of intellectual disability with behavioral problems and dysmorphisms.
Jansen S, van der Werf IM, Innes AM, Afenjar A, Agrawal PB, Anderson IJ, Atwal PS, van Binsbergen E, van den Boogaard MJ, Castiglia L, Coban-Akdemir ZH, van Dijck A, Doummar D, van Eerde AM, van Essen AJ, van Gassen KL, Guillen Sacoto MJ, van Haelst MM, Iossifov I, Jackson JL, Judd E, Kaiwar C, Keren B, Klee EW, Klein Wassink-Ruiter JS, Meuwissen ME, Monaghan KG, de Munnik SA, Nava C, Ockeloen CW, Pettinato R, Racher H, Rinne T, Romano C, Sanders VR, Schnur RE, Smeets EJ, Stegmann APA, Stray-Pedersen A, Sweetser DA, Terhal PA, Tveten K, VanNoy GE, de Vries PF, Waxler JL, Willing M, Pfundt R, Veltman JA, Kooy RF, Vissers LELM, de Vries BBA. Jansen S, et al. Eur J Hum Genet. 2019 May;27(5):738-746. doi: 10.1038/s41431-018-0292-2. Epub 2019 Jan 24. Eur J Hum Genet. 2019. PMID: 30679813 Free PMC article.
We describe 24 individuals with a de novo disease-causing variant in, or partial deletion of, the F-box only protein 11 gene (FBXO11, also known as VIT1 and PRMT9). FBXO11 is part of the SCF (SKP1-cullin-F-box) complex, a multi-protein E3 ubiquitin-ligase complex ca …
We describe 24 individuals with a de novo disease-causing variant in, or partial deletion of, the F-box only protein 11 gene (FBXO11, …
NDR1/FBXO11 promotes phosphorylation-mediated ubiquitination of beta-catenin to suppress metastasis in prostate cancer.
Xuan Z, Chen C, Sun H, Yang K, Li J, Fu M, Bai Y, Zheng Z, Zhao Y, Xu C, Liu B, Li T, Shao C. Xuan Z, et al. Int J Biol Sci. 2024 Sep 16;20(12):4957-4977. doi: 10.7150/ijbs.98907. eCollection 2024. Int J Biol Sci. 2024. PMID: 39309441 Free PMC article.
Results: NDR1 phosphorylated beta-catenin at Ser33/37, facilitating its interaction with FBXO11. This led to FBXO11-mediated ubiquitination and cytoplasmic degradation of beta-catenin, while the NDR1-FBXO11 complex impeded beta-catenin nuclear translocation b …
Results: NDR1 phosphorylated beta-catenin at Ser33/37, facilitating its interaction with FBXO11. This led to FBXO11-mediated u …
FBXO11 variants are associated with intellectual disability and variable clinical manifestation in Chinese affected individuals.
Pan X, Liu L, Zhang X, Tang X, Qian G, Qiu H, Lin S, Yao H, Dong X, Tan B. Pan X, et al. J Hum Genet. 2024 Aug;69(8):391-400. doi: 10.1038/s10038-024-01255-4. Epub 2024 May 13. J Hum Genet. 2024. PMID: 38740982
Distinguishingly, malformation was not observed in all the affected individuals. WES analysis showed 5 novel FBXO11 variants, which include an inframe deletion variant, a missense variant, two frameshift variants, and a partial deletion of FBXO11 (exon 22-23). RNA-s …
Distinguishingly, malformation was not observed in all the affected individuals. WES analysis showed 5 novel FBXO11 variants, which i …
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins.
Jeon Y, Chow SH, Stuart I, Weir A, Yeung AT, Hale C, Sridhar S, Dougan G, Vince JE, Naderer T. Jeon Y, et al. Life Sci Alliance. 2023 Mar 28;6(6):e202201735. doi: 10.26508/lsa.202201735. Print 2023 Jun. Life Sci Alliance. 2023. PMID: 36977592 Free PMC article.
Here, we used a genome-wide CRISPR/Cas9 screen and identified F-box protein 11 (FBXO11), an E3 ubiquitin ligase complex member, to promote PVL toxicity. Genetic deletion of FBXO11 reduced the expression of C5aR1 at the mRNA level, whereas ectopic expression of C5aR1 …
Here, we used a genome-wide CRISPR/Cas9 screen and identified F-box protein 11 (FBXO11), an E3 ubiquitin ligase complex member, to pr …
FBXO11 suppression rewires an NPM1-centered interactome influencing the progression of myelodysplastic syndrome.
Niederkorn M, Bezavada L, Cotton A, Palmer LE, Konada L, Hall T, Pagala VR, Zhai J, Yuan ZF, Fu Y, Steele JA, Narina S, Schild A, Wu C, Aminov S, Schieber M, McGovern E, Taylor AB, Gurbuxani S, Xu P, Ji P, Janke LJ, High AA, Kang G, Pruett-Miller SM, Weiss M, Verma A, Rampal RK, Crispino JD. Niederkorn M, et al. J Clin Invest. 2026 Jan 16;136(2):e193636. doi: 10.1172/JCI193636. eCollection 2026 Jan 16. J Clin Invest. 2026. PMID: 41542766 Free PMC article.
FBXO11 facilitates the ubiquitylation of NPM1, whereby deletion of FBXO11 results in the reorganization of NPM1 and a de-repression of alternative splicing. ...In addition, we discovered that MYC was evicted from the FBXO11 promoter by TLR2 activation, reveal …
FBXO11 facilitates the ubiquitylation of NPM1, whereby deletion of FBXO11 results in the reorganization of NPM1 and a de-repre …
How many phenotypes for the FBXO11 related disease? Report on a new patient with a tricho-rhino-phalangeal like phenotype.
Mégarbané A, Mehawej C, Mahfoud D, Chouery E, Devriendt K, Hijazi M, Ryu SW, Kim J, McNeill A. Mégarbané A, et al. Eur J Med Genet. 2024 Jun;69:104944. doi: 10.1016/j.ejmg.2024.104944. Epub 2024 Apr 26. Eur J Med Genet. 2024. PMID: 38679370 Free article.
Given that TRPS had been excluded by a thorough genetic analysis, whole exome sequencing was performed and a heterozygous likely pathogenic variant was identified in the FBXO11 gene (NM_001190274.2: c.1781A > G; p. His594Arg), confirming the diagnosis of the newly indiv …
Given that TRPS had been excluded by a thorough genetic analysis, whole exome sequencing was performed and a heterozygous likely pathogenic …
FBXO11 Mediates Ubiquitination of ZEB1 and Modulates Epithelial-to-Mesenchymal Transition in Lung Cancer Cells.
Zhao X, Han Z, Liu R, Li Z, Mei L, Jin Y. Zhao X, et al. Cancers (Basel). 2024 Sep 26;16(19):3269. doi: 10.3390/cancers16193269. Cancers (Basel). 2024. PMID: 39409891 Free PMC article.
FBXO11 interacts with ZEB1, a core inducer of EMT. FBXO11 leads to increased ubiquitination and proteasomal degradation of ZEB1. Depletion of endogenous FBXO11 causes ZEB1 protein accumulation and EMT in A549 and H1299 cells, while overexpression of FBXO11 …
FBXO11 interacts with ZEB1, a core inducer of EMT. FBXO11 leads to increased ubiquitination and proteasomal degradation of ZEB …
FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
Kasuga Y, Ouda R, Watanabe M, Sun X, Kimura M, Hatakeyama S, Kobayashi KS. Kasuga Y, et al. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2218955120. doi: 10.1073/pnas.2218955120. Epub 2023 Jun 6. Proc Natl Acad Sci U S A. 2023. PMID: 37279268 Free PMC article.
Moreover, human and mouse FBXO11-deficient cells display increased levels of MHC-II and related genes. In normal and cancer tissues, FBXO11 expression level is negatively correlated with MHC-II. Interestingly, the expression of FBXO11, along with CIITA, is as …
Moreover, human and mouse FBXO11-deficient cells display increased levels of MHC-II and related genes. In normal and cancer tissues, …
FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis.
Xu P, Scott DC, Xu B, Yao Y, Feng R, Cheng L, Mayberry K, Wang YD, Bi W, Palmer LE, King MT, Wang H, Li Y, Fan Y, Alpi AF, Li C, Peng J, Papizan J, Pruett-Miller SM, Spallek R, Bassermann F, Cheng Y, Schulman BA, Weiss MJ. Xu P, et al. Blood. 2021 Jan 14;137(2):155-167. doi: 10.1182/blood.2020007809. Blood. 2021. PMID: 33156908 Free PMC article.
Erythroblasts lacking FBXO11 are developmentally delayed, with reduced expression of maturation-associated genes, most of which harbor bivalent histone marks at their promoters. In FBXO11-/- erythroblasts, these gene promoters bind BAHD1 and fail to recruit the eryt …
Erythroblasts lacking FBXO11 are developmentally delayed, with reduced expression of maturation-associated genes, most of which harbo …
160 results